Home>Results

  • Complex
  • Title
  • Keyword
  • Abstract
  • Scholars
  • Journal
  • ISSN
  • Conference
成果搜索

[期刊论文]

Cytotoxic study in the treatment of tetracycline by using magnetic Fe3O4-PAMAM-antibody complexes

Share
Edit Delete 报错

author:

Ou, Minrui (Ou, Minrui.) [1] (Scholars:欧敏锐) | Zhang, Zihui (Zhang, Zihui.) [2] | Wen, Yukai (Wen, Yukai.) [3] | Unfold

Indexed by:

Scopus SCIE

Abstract:

Antibiotics are widely used as drugs to treathuman and animaldiseases. However, the widespread use of antibiotics has induced environmental contamination by antibiotics and development of resistant bacteria. There thus a need for advanced methods to remove antibiotics, e.g. from natural waters. Here we used the concept thatantigens and antibodies bind specificallyto remove tetracycline. Magnetic Fe3O4-polyamidoamine(PAMAM)-antibody complexes were synthesized to remove tetracycline at optimum pH and temperature. Invitro cytotoxicity of tetracycline/treated solutions was evaluated in human skin fibroblasts (HSF) cells by using MTT dyeassay, along with flow cytometry study for cell cycle distributions and cell apoptosis. The results show that the toxicity of tetracycline solutions was highlyreduced after treatment by magnetic Fe3O4-PAMAM-antibody complexes, and the survival rate of the cells was increased. The tetracycline may induce the disintegration of the nucleosomes of the HSF cells and eventually lead to the cell apoptosis. The results show that the method of removing tetracycline has higher biosafety.

Keyword:

Biosafety Cytotoxicity Environment Fe3O4-PAMAM-antibody Specific treatment Tetracycline

Community:

  • [ 1 ] [Ou, Minrui]Fuzhou Univ, Coll Chem Engn, Fuzhou 350116, Fujian, Peoples R China
  • [ 2 ] [Yang, Huanghao]Fuzhou Univ, Coll Chem Engn, Fuzhou 350116, Fujian, Peoples R China
  • [ 3 ] [Ou, Minrui]Fuzhou Univ, Coll Chem, Fuzhou 350116, Fujian, Peoples R China
  • [ 4 ] [Zhang, Zihui]Fuzhou Univ, Coll Chem, Fuzhou 350116, Fujian, Peoples R China
  • [ 5 ] [Wen, Yukai]Fuzhou Univ, Coll Chem, Fuzhou 350116, Fujian, Peoples R China
  • [ 6 ] [Yang, Huanghao]Fuzhou Univ, Coll Chem, Fuzhou 350116, Fujian, Peoples R China
  • [ 7 ] [Gu, Junjie]Fuzhou Univ, Coll Chem, Fuzhou 350116, Fujian, Peoples R China
  • [ 8 ] [Xu, Xiaoping]Fuzhou Univ, Coll Chem, Fuzhou 350116, Fujian, Peoples R China

Reprint 's Address:

  • 欧敏锐 许小平

    [Ou, Minrui]Fuzhou Univ, Coll Chem Engn, Fuzhou 350116, Fujian, Peoples R China;;[Ou, Minrui]Fuzhou Univ, Coll Chem, Fuzhou 350116, Fujian, Peoples R China;;[Xu, Xiaoping]Fuzhou Univ, Coll Chem, Fuzhou 350116, Fujian, Peoples R China

Show more details

Source :

ENVIRONMENTAL CHEMISTRY LETTERS

ISSN: 1610-3653

Year: 2019

Issue: 1

Volume: 17

Page: 543-549

5 . 9 2 2

JCR@2019

1 5 . 0 0 0

JCR@2023

ESI Discipline: CHEMISTRY;

ESI HC Threshold:184

JCR Journal Grade:1

CAS Journal Grade:3

Cited Count:

WoS CC Cited Count: 7

SCOPUS Cited Count: 8

30 Days PV: 0

查看更多>>操作日志

管理员  2025-02-14 00:22:07  更新被引

管理员  2025-02-11 23:07:58  更新被引

管理员  2024-08-22 07:07:50  更新被引

管理员  2024-07-16 06:11:38  更新被引

Online/Total:407/10752569
Address:FZU Library(No.2 Xuyuan Road, Fuzhou, Fujian, PRC Post Code:350116) Contact Us:0591-22865326
Copyright:FZU Library Technical Support:Beijing Aegean Software Co., Ltd. 闽ICP备05005463号-1