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学者姓名：杨黄浩
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Abstract ：
Evaluating tumor radiosensitivity is beneficial for the prediction of treatment efficacy, customization of treatment plans, and minimization of side effects. Tracking the mitochondrial DNA (mtDNA) repair process helps to assess tumor radiosensitivity as mtDNA repair determines the fate of the cell under radiation-induced mtDNA damage. However, current probes developed to monitor levels of DNA repair enzymes suffered from complex synthesis, uncontrollable preparation, limited tumor selectivity, and poor organelle-targeting ability. Especially, the correlation between mtDNA repair activity and inherent radiosensitivity of tumors has not yet been explored. Here, we present a mitochondria-targeted DNA-based nanoprobe (TPP-Apt-tFNA) for in situ monitoring of the activity of the mtDNA repair enzyme and evaluating tumor radiosensitivity. TPP-Apt-tFNA consists of a DNA tetrahedral framework precisely modified with three functional modules on each of the three vertexes, that is, the tumor cell-targeting aptamer, the mitochondrion-targeting moiety, and the apurinic/apyrimidinic endonuclease 1 (APE1)-responsive molecule beacon. Once selectively internalized by tumor cells, the nanoprobe targeted the mitochondrion and specifically recognized APE1 to activate fluorescence, allowing the observation of mtDNA repair activity. The nanoprobe showed elevated APE1 levels in the mitochondria of tumor cells under oxidative stress. Moreover, the nanoprobe enabled the illumination of different levels of APE1-mediated mtDNA repair activity in different cell cycle phases. Furthermore, using the nanoprobe in vitro and in vivo, we found that tumor cells with high activity of mtDNA repair, which allowed them to recover from radiation-induced mtDNA lesions, had low sensitivity to radiation and an unsatisfactory radiotherapy outcome. Our work provides a new imaging tool for exploring the roles of mtDNA repair activity in diverse biological processes and for guiding tumor radiation treatment.
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| GB/T 7714 | Chen, Lanlan , Lai, Jingjing , Dong, Siqi et al. Mitochondria-Targeted DNA-Based Nanoprobe for In Situ Monitoring of the Activity of the mtDNA Repair Enzyme and Evaluating Tumor Radiosensitivity [J]. | ANALYTICAL CHEMISTRY , 2025 , 97 (1) : 382-391 . |
| MLA | Chen, Lanlan et al. "Mitochondria-Targeted DNA-Based Nanoprobe for In Situ Monitoring of the Activity of the mtDNA Repair Enzyme and Evaluating Tumor Radiosensitivity" . | ANALYTICAL CHEMISTRY 97 . 1 (2025) : 382-391 . |
| APA | Chen, Lanlan , Lai, Jingjing , Dong, Siqi , Liu, Wenjun , Zhang, Ximei , Yang, Huanghao . Mitochondria-Targeted DNA-Based Nanoprobe for In Situ Monitoring of the Activity of the mtDNA Repair Enzyme and Evaluating Tumor Radiosensitivity . | ANALYTICAL CHEMISTRY , 2025 , 97 (1) , 382-391 . |
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Ultrasmall gold nanoclusters (AuNCs) with photoluminescence in the second near-infrared region (NIR-II) have emerged as promising probes for in vivo biomedical applications. However, it remains a challenge to utilize NIR-II-emitting AuNCs for imaging brain glioblastoma (GBM), which is highly lethal and hard to diagnose in time. Herein, we have presented systematic investigations on the brain delivery and GBM targeting efficacies of NIR-II-emitting AuNCs protected by different ligands. We first synthesized four types of AuNCs with surface coatings of small thiolated ligands and proteins, and then studied their in vitro penetration capability into the blood-brain barrier (BBB) and in vivo GBM targeting performances. It was found that the BBB permeability of AuNCs determined by the in vitro transwell model was not evidently affected by the surface ligands. Significantly, AuNCs protected by albumin exhibited notably extended blood circulation and less skull binding compared to those protected by small ligands, enabling superior in vivo brain GBM-targeted NIR-II PL imaging. We also modified the albumin-AuNCs with targeting peptides to improve in vivo imaging contrast. Additionally, AuNCs had negligible toxic effects on major organs as well as brain tissues and neurons, corroborating their good biocompatibility. This study examined the surface engineering of NIR-II luminescent AuNCs for brain GBM targeting, which may offer insights into the future design of AuNCs for bioapplications.
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| GB/T 7714 | Tong, Shufen , Liu, Jie , Chen, Yonghui et al. Surface engineering of NIR-II luminescent gold nanoclusters for brain glioma-targeted imaging [J]. | NANOSCALE , 2025 , 17 (17) : 10670-10676 . |
| MLA | Tong, Shufen et al. "Surface engineering of NIR-II luminescent gold nanoclusters for brain glioma-targeted imaging" . | NANOSCALE 17 . 17 (2025) : 10670-10676 . |
| APA | Tong, Shufen , Liu, Jie , Chen, Yonghui , Xiao, Xinyun , Li, Shihua , Song, Xiaorong et al. Surface engineering of NIR-II luminescent gold nanoclusters for brain glioma-targeted imaging . | NANOSCALE , 2025 , 17 (17) , 10670-10676 . |
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In recent years, metal halide perovskites have garnered significant attention in the field of X-ray detection due to their outstanding photoelectric properties, high X-ray attenuation coefficients, and the advantage of being able to be fabricated by low-cost solution processing methods. However, a major challenge in developing perovskite X-ray detectors lies in the low quality of films produced through solution processing. In this work, we introduce an efficient method that employs a straightforward blade-coating technique to successfully prepare MAPbI3 perovskite films with a thickness of tens of microns under ambient conditions. To further improve the quality of the MAPbI3 films, we incorporate the polymer polyvinylpyrrolidone (PVP) into the perovskite precursor solution. The addition of PVP promotes crystal growth, resulting in an enlarged grain size and a more uniform arrangement within the perovskite film. This enhancement leads to a reduction in defect density and subsequent improvement in the charge collection efficiency. Consequently, the detector manufactured using the PVP-optimized film exhibits an enhanced X-ray sensitivity of 2.6 x 103 mu C Gyair-1 cm-2 and achieves a low detection limit of 11 nGyair s-1 under 10 keV X-ray energy, surpassing those achieved with the original perovskite film which measured 0.60 x 103 mu C Gyair-1 cm-2 and 139 nGyair s-1 under the same conditions. This work unlocks new prospects for the straightforward and cost-effective manufacture of high-performance X-ray detectors.
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| GB/T 7714 | Hua, Yanlong , Chen, Jiahui , Guo, Cuiling et al. Polyvinylpyrrolidone-enhanced perovskite films for efficient direct X-ray detection [J]. | JOURNAL OF MATERIALS CHEMISTRY C , 2025 , 13 (18) : 9365-9373 . |
| MLA | Hua, Yanlong et al. "Polyvinylpyrrolidone-enhanced perovskite films for efficient direct X-ray detection" . | JOURNAL OF MATERIALS CHEMISTRY C 13 . 18 (2025) : 9365-9373 . |
| APA | Hua, Yanlong , Chen, Jiahui , Guo, Cuiling , Chen, Shan-Ci , He, Yu , Yang, Huanghao . Polyvinylpyrrolidone-enhanced perovskite films for efficient direct X-ray detection . | JOURNAL OF MATERIALS CHEMISTRY C , 2025 , 13 (18) , 9365-9373 . |
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Pyroptosis is gaining attention for its ability to activate the immune system. However, controlling the induction of specific pyroptotic tumor cell death to effectively activate the immune response is a challenge. In this study, a novel "bacterial bomb" platform is developed and designed to precisely regulate tumor cell pyroptosis using light as a trigger, thereby optimizing immune responses. The platform employs Escherichia coli (Ec) as a carrier to introduce gasdermin D (GSDMD) plasmid (pGSDMD) into Ec and adsorb photosensitizer indocyanine green (ICG) on its surface, termed as Ec-pGSDMD-ICG. ICG has photothermal effects (PTE) and photodynamic effects (PDE). Under 808 nm laser irradiation, ICG generates thermal effects and singlet oxygen (O-1(2)), leading to Ec rupture and the release of pGSDMD, which expresses sufficient GSDMD in tumor cells. Furthermore, O-1(2) and lipopolysaccharides (LPS) of Ec activate caspase pathways (caspase-1 and caspase-11), which cleave GSDMD to produce GSDMD-N, thereby inducing pyroptosis and immune responses. Light triggered Ec-pGSDMD-ICG not only efficiently induces pyroptosis in tumor cells with low GSDMD content, but also enhances the pyroptosis in tumor cells with moderate GSDMD content, all while activating the immune system for effective tumor treatment. This approach opens new strategies and research directions for pyroptosis mediated tumor immunotherapy.
Keyword ：
bacterial bomb bacterial bomb caspase pathways caspase pathways GSDMD GSDMD immunotherapy immunotherapy pyroptosis pyroptosis
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| GB/T 7714 | Liu, Yana , Zeng, Tao , Bai, Shiyan et al. Light Triggered "Bacterial Bomb" to Amplify Tumor Pyroptosis [J]. | ADVANCED FUNCTIONAL MATERIALS , 2025 . |
| MLA | Liu, Yana et al. "Light Triggered "Bacterial Bomb" to Amplify Tumor Pyroptosis" . | ADVANCED FUNCTIONAL MATERIALS (2025) . |
| APA | Liu, Yana , Zeng, Tao , Bai, Shiyan , Fang, Xiao , Cao, Xiuping , Li, Shiqing et al. Light Triggered "Bacterial Bomb" to Amplify Tumor Pyroptosis . | ADVANCED FUNCTIONAL MATERIALS , 2025 . |
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Proteolysis-targeting chimeras (PROTACs) are dual-functional molecules composed of a protein of interest (POI) ligand and an E3 ligase ligand connected by a linker, which can recruit POI and E3 ligases simultaneously, thereby inducing the degradation of POI and showing great potential in disease treatment. A challenge in developing PROTACs is the design of linkers and the modification of ligands to establish a multifunctional platform that enhances degradation efficiency and antitumor activity. As a programmable and modifiable nanomaterial, DNA tetrahedron can precisely assemble and selectively recognize molecules and flexibly adjust the distance between molecules, making them ideal linkers. Herein, we developed a multivalent PROTAC based on a DNA tetrahedron, named AS-TD2-PRO. Using DNA tetrahedron as a linker, we combined modules targeting tumor cells, recognizing E3 ligases, and multiple POI together. We took the undruggable target protein signal transducer and activator of transcription 3 (STAT3), associated with the etiology and progression in a variety of malignant tumors, as an example in this study. AS-TD2-PRO with two STAT3 recognition modules demonstrated good potential in enhancing tumor-specific targeting and degradation efficiency compared to traditional bivalent PROTACs. Furthermore, in a mouse tumor model, the superior therapeutic activity of AS-TD2-PRO was observed. Overall, DNA tetrahedron-driven multivalent PROTACs both serve as a proof of principle for multifunctional PROTAC design and introduce a promising avenue for cancer treatment strategies.
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| GB/T 7714 | Li, Shiqing , Zeng, Tao , Wu, Zhixing et al. DNA Tetrahedron-Driven Multivalent Proteolysis-Targeting Chimeras: Enhancing Protein Degradation Efficiency and Tumor Targeting [J]. | JOURNAL OF THE AMERICAN CHEMICAL SOCIETY , 2025 , 147 (2) : 2168-2181 . |
| MLA | Li, Shiqing et al. "DNA Tetrahedron-Driven Multivalent Proteolysis-Targeting Chimeras: Enhancing Protein Degradation Efficiency and Tumor Targeting" . | JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 147 . 2 (2025) : 2168-2181 . |
| APA | Li, Shiqing , Zeng, Tao , Wu, Zhixing , Huang, Jiabao , Cao, Xiuping , Liu, Yana et al. DNA Tetrahedron-Driven Multivalent Proteolysis-Targeting Chimeras: Enhancing Protein Degradation Efficiency and Tumor Targeting . | JOURNAL OF THE AMERICAN CHEMICAL SOCIETY , 2025 , 147 (2) , 2168-2181 . |
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Benefiting from the unique properties of ionizing radiation, such as high tissue penetration, spatiotemporal resolution, and clinical relevance compared with other external stimuli, radiotherapy-induced drug release strategies are showing great promise in developing effective and personalized cancer treatments. However, the requirement of high doses of X-ray irradiation to break chemical bonds for drug release limits the application of radiotherapy-induced prodrug activation in clinics. Recent advances in nanomaterials offer a promising approach for radiotherapy sensitization as well as integrating multiple modalities for improved therapy outcomes. In particular, the catalytic radiosensitization that utilizes electrons and energy generated by nanomaterials upon X-ray irradiation has demonstrated excellent potential for enhanced radiotherapy. In this Review, we summarize the design principles of X-ray-responsive chemical bonds for controlled drug release, strategies for catalytic radiosensitization, and recent progress of X-ray-responsive nanoradiosensitizers for enhanced radiotherapy by integration with chemotherapy, chemodynamic therapy, photodynamic therapy, photothermal therapy, gas therapy, and immunotherapy. Finally, we discuss the challenges of X-ray-responsive nanoradiosensitizers heading toward possible clinical translation. We expect that emerging strategies based on radiotherapy-triggered drug release will facilitate a frontier in accurate and effective cancer therapy in the near future.
Keyword ：
combined therapy combined therapy nanomaterials nanomaterials radiosensitive radiosensitive radiotherapy radiotherapy X-ray responsivedrug release X-ray responsivedrug release
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| GB/T 7714 | Jiang, Renfeng , Fang, Qiong , Liu, Wenjun et al. Recent Progress in Radiosensitive Nanomaterials for Radiotherapy-Triggered Drug Release [J]. | ACS APPLIED MATERIALS & INTERFACES , 2025 , 17 (10) : 14801-14821 . |
| MLA | Jiang, Renfeng et al. "Recent Progress in Radiosensitive Nanomaterials for Radiotherapy-Triggered Drug Release" . | ACS APPLIED MATERIALS & INTERFACES 17 . 10 (2025) : 14801-14821 . |
| APA | Jiang, Renfeng , Fang, Qiong , Liu, Wenjun , Chen, Lanlan , Yang, Huanghao . Recent Progress in Radiosensitive Nanomaterials for Radiotherapy-Triggered Drug Release . | ACS APPLIED MATERIALS & INTERFACES , 2025 , 17 (10) , 14801-14821 . |
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The development of RNA interference (RNAi) therapy offers a potential solution for Alzheimer's disease (AD). However, the brain-blood barrier (BBB) with its selective permeability and pharmacokinetic-related challenges poses restrictions on the delivery of small interfering RNA (siRNA) to the central nervous system (CNS). In this study, we demonstrate that the incorporation of 2 '-fluoro (2 '-F) substitutions and L-carnitine modification facilitates the self-assembly of siRNA through triple interaction, leading to the formation of nanorings, called LCSF-NR. Based on the enhanced cellular uptake and lysosomal escape by 2 '-F substitution and the transport across the BBB promoted by L-carnitine, the nanorings realized the improved brain-targeted delivery of siRNA, both in zebrafish and mice models. Moreover, our findings highlight the therapeutic potential of LCSF-NR formulation in an AD zebrafish model through a synergistic effect of downregulating the beta-site APP cleavage enzyme 1 (BACE1) gene and L-carnitine-mediated neuroprotection, effectively inhibiting pathological processes. Overall, these results suggest that the chemical modification-based siRNA self-assembly strategy enables trans-BBB delivery and presents a concise approach for synergistic therapy of AD.
Keyword ：
Alzheimer's disease Alzheimer's disease blood-brain barrier blood-brain barrier chemical modification chemical modification self-assembly self-assembly siRNA siRNA
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| GB/T 7714 | Jiang, Yifan , Li, Lisha , Fang, Xiao et al. Self-assembling chemically modified siRNA nanorings for RNAi therapy and neuroprotection in Alzheimer's disease [J]. | SCIENCE CHINA-CHEMISTRY , 2025 . |
| MLA | Jiang, Yifan et al. "Self-assembling chemically modified siRNA nanorings for RNAi therapy and neuroprotection in Alzheimer's disease" . | SCIENCE CHINA-CHEMISTRY (2025) . |
| APA | Jiang, Yifan , Li, Lisha , Fang, Xiao , Zeng, Tao , Su, Lichao , Liu, Yichang et al. Self-assembling chemically modified siRNA nanorings for RNAi therapy and neuroprotection in Alzheimer's disease . | SCIENCE CHINA-CHEMISTRY , 2025 . |
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Pickering emulsions are dispersions of two immiscible liquids stabilized by surface-active colloidal nano-/microparticles. Their compartmentalized structures closely resemble the characteristics of cellular and subcellular systems, enabling the development of biomimetic microreactors that enhance catalytic processes. By enlarging interfacial areas while effectively partitioning reactants into their preferred phases, Pickering emulsion-based microreactors improve kinetic parameters and prevent unwanted interactions. The adaptability of Pickering emulsions is further augmented through modifications to the properties and composition of the particle emulsifiers, rendering them multifunctional and facilitating efficient reactions between immiscible phases, such as oil and water, especially when the emulsifiers themselves act as catalysts. This review summarizes recent advances in Pickering emulsion-based biomimetic microreactors, focusing on the versatile choice of various particles, design principles, and their applications in facilitating biphasic catalysis in a biomimetic way. We also discuss the challenges and future perspectives for further refining these microreactors for enhanced biphasic catalytic processes.
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| GB/T 7714 | Xu, Xiao , Zhou, Min , Wu, Ting et al. Pickering emulsion-based biomimetic microreactors [J]. | MATERIALS CHEMISTRY FRONTIERS , 2025 , 9 (8) : 1290-1311 . |
| MLA | Xu, Xiao et al. "Pickering emulsion-based biomimetic microreactors" . | MATERIALS CHEMISTRY FRONTIERS 9 . 8 (2025) : 1290-1311 . |
| APA | Xu, Xiao , Zhou, Min , Wu, Ting , Chen, Zhaowei , Yang, Huanghao . Pickering emulsion-based biomimetic microreactors . | MATERIALS CHEMISTRY FRONTIERS , 2025 , 9 (8) , 1290-1311 . |
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| GB/T 7714 | Yang, Zhijian , Xu, Qiaohong , Chen, Qiushui et al. Breaking the boundaries of biological penetration depth: X-ray luminescence in light theranostics [J]. | SCIENCE CHINA-CHEMISTRY , 2024 , 67 (4) : 1056-1059 . |
| MLA | Yang, Zhijian et al. "Breaking the boundaries of biological penetration depth: X-ray luminescence in light theranostics" . | SCIENCE CHINA-CHEMISTRY 67 . 4 (2024) : 1056-1059 . |
| APA | Yang, Zhijian , Xu, Qiaohong , Chen, Qiushui , Yang, Huanghao . Breaking the boundaries of biological penetration depth: X-ray luminescence in light theranostics . | SCIENCE CHINA-CHEMISTRY , 2024 , 67 (4) , 1056-1059 . |
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It remains a challenge to use a single probe to simultaneously detect extracellular pH fluctuations and specifically recognize cancer cells for precise drug delivery. Here, we engineered a tetrahedral framework nucleic acid-based logic nanoprobe (isgc8-tFNA) on live cell membranes for simultaneously monitoring extracellular pH and targeted drug delivery. Isgc8-tFNA was anchored stably on the cell surface through three cholesterol molecules inserting into the bilayer of the cell membrane. Once responding to the acidic tumor microenvironment, isgc8-tFNA formed an i-motif structure, leading to turn-on FRET signals for monitoring changes of extracellular pH. The nanoprobe exhibited a narrow pH-response window and excellent reversibility. Moreover, the nanoprobe could execute logic identification on the cell surface for precise drug delivery. Only if both in the acidic microenvironment and aptamer-targeting marker are present on the cell surface, the sgc8-ASO-chimera strand, carrying an antisense oligonucleotide drug, was released from the nanoprobe and entered into targeted cancer cells for gene silence. Additionally, the in situ drug release facilitated the uptake of drugs mediated by the interaction between sgc8 aptamer and membrane proteins, resulting in enhanced inhibition of cancer cell migration and proliferation. This logic nanoprobe will provide inspiration for designing smart devices for diagnosis of pH-related diseases and targeted drug delivery.
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| GB/T 7714 | Chen, Wanzhen , Lai, Jingjing , Dong, Siqi et al. Engineering Logic DNA Nanoprobes on Live Cell Membranes for Simultaneously Monitoring Extracellular pH and Precise Drug Delivery [J]. | ANALYTICAL CHEMISTRY , 2024 , 96 (8) : 3462-3469 . |
| MLA | Chen, Wanzhen et al. "Engineering Logic DNA Nanoprobes on Live Cell Membranes for Simultaneously Monitoring Extracellular pH and Precise Drug Delivery" . | ANALYTICAL CHEMISTRY 96 . 8 (2024) : 3462-3469 . |
| APA | Chen, Wanzhen , Lai, Jingjing , Dong, Siqi , Chen, Lanlan , Yang, Huanghao . Engineering Logic DNA Nanoprobes on Live Cell Membranes for Simultaneously Monitoring Extracellular pH and Precise Drug Delivery . | ANALYTICAL CHEMISTRY , 2024 , 96 (8) , 3462-3469 . |
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