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学者姓名：欧敏锐
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Abstract ：
Conotoxins(CTXs) can specifically act on multiple ion channels, which are crucial for the development of neurobiology and novel targeted drug development. At present, >10,000 kinds of CTXs have been sequenced, it would be extremely laborious to conduct experiments for each. mu-CTX KIIIA is a type of substance that can selectively recognize voltage-gated sodium ion channels. This article constructs four derivatives of KIIIA and predicts their 3D structures; afterwards, their molecular orbital arrangements and physicochemical properties were calculated using DFT; then, predicted their toxicokinetic parameters such as absorption, distribution, metabolism, excretion (ADME) and toxicity (T) through Machine Learning (ML); finally, molecular docking and molecular dynamics are used to investigate the interaction modes and binding affinity. The results indicate that the toxicity of KIIIA and its derivatives (KIIIA-1 -KIIIA-4) to the human body is mainly concentrated in the liver and respiratory tract. Among four derivatives, KIIIA-2 (5 Ser -> Arg) has better toxicokinetics properties and its binding energy to Na(v)1.2 is -65.32 kcal/mol, which is higher than that of wild type(-32.13 kcal/mol). This study indicate that computational toxicology can facilitate the druggability research of CTXs, and KIIIA-2 can be developed as a potential antiepileptic drug.
Keyword ：
Computational toxicology Computational toxicology Conotoxins Conotoxins Voltage-gated sodium channels Voltage-gated sodium channels
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| GB/T 7714 | Ou, Minrui , Xu, Suyan , Huang, Zhixuan et al. In silico toxicology investigation of μ-conotoxin KIIIA on human Na+ channel Nav1.2 [J]. | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES , 2025 , 298 . |
| MLA | Ou, Minrui et al. "In silico toxicology investigation of μ-conotoxin KIIIA on human Na+ channel Nav1.2" . | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 298 (2025) . |
| APA | Ou, Minrui , Xu, Suyan , Huang, Zhixuan , Xu, Xiaoping . In silico toxicology investigation of μ-conotoxin KIIIA on human Na+ channel Nav1.2 . | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES , 2025 , 298 . |
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Uranium extraction from seawater (UES) has important strategic significance for maintaining the sustainable development of nuclear energy. This article presents the preparation of a low-cost, efficient, and highly reusable biosorbent sodium alginate/polyethyleneimine (SA/PEI) through a simple one-step crosslinking process. The chemical crosslinking between PEI and SA provides biosorbent excellent mechanical strength and thermal stability. SA/PEI was characterized by using FTIR, XRD, TGA, EDS, XPS, SEM before and after adsorption of uranium. Thermodynamic research results show that the uranium adsorption of SA/PEI is a spontaneous, entropy increasing endothermic process. The adsorption fitted the pseudo-second-order kinetic model and Langmuir model with maximum adsorption capacity reach 353.09 mg g−1, illustrating that the adsorption mechanism is monolayer chemical adsorption. The interaction between SA/PEI and uranium is synergistic chelation by amino and carboxyl, which is consistent with the results calculated by DFT. After 14 days of adsorption in 100 L natural seawater, the adsorption capacity of SA/PEI was 3.58 mg g−1, with an average adsorption efficiency of 0.256 mg g−1 day−1, which is faster than most reported alginate adsorbents. The cost of using SA/PEI to UES is $168 per kilogram of uranium. These results indicate that SA/PEI hydrogel has great potential in practical seawater application. © 2024 Elsevier B.V.
Keyword ：
Biosorbent Biosorbent Sodium alginate/polyethyleneimine Sodium alginate/polyethyleneimine Uranium (VI) extraction Uranium (VI) extraction
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| GB/T 7714 | Huang, Z. , Li, W. , Xu, S. et al. A novel sponge-like composite biosorbent fabricated by sodium alginate and polyethyleneimine for uranium(VI) extraction from seawater [J]. | International Journal of Biological Macromolecules , 2024 , 279 . |
| MLA | Huang, Z. et al. "A novel sponge-like composite biosorbent fabricated by sodium alginate and polyethyleneimine for uranium(VI) extraction from seawater" . | International Journal of Biological Macromolecules 279 (2024) . |
| APA | Huang, Z. , Li, W. , Xu, S. , Xu, X. , Ou, M. . A novel sponge-like composite biosorbent fabricated by sodium alginate and polyethyleneimine for uranium(VI) extraction from seawater . | International Journal of Biological Macromolecules , 2024 , 279 . |
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Abstract ：
Uranium extraction from seawater (UES) has important strategic significance for maintaining the sustainable development of nuclear energy. This article presents the preparation of a low-cost, efficient, and highly reusable biosorbent sodium alginate/polyethyleneimine (SA/PEI) through a simple one-step crosslinking process. The chemical crosslinking between PEI and SA provides biosorbent excellent mechanical strength and thermal stability. SA/PEI was characterized by using FTIR, XRD, TGA, EDS, XPS, SEM before and after adsorption of uranium. Thermodynamic research results show that the uranium adsorption of SA/PEI is a spontaneous, entropy increasing endothermic process. The adsorption fitted the pseudo-second-order kinetic model and Langmuir model with maximum adsorption capacity reach 353.09 mg g- 1, illustrating that the adsorption mechanism is monolayer chemical adsorption. The interaction between SA/PEI and uranium is synergistic chelation by amino and carboxyl, which is consistent with the results calculated by DFT. After 14 days of adsorption in 100 L natural seawater, the adsorption capacity of SA/PEI was 3.58 mg g- 1, with an average adsorption efficiency of 0.256 mg g- 1 day- 1, which is faster than most reported alginate adsorbents. The cost of using SA/PEI to UES is $168 per kilogram of uranium. These results indicate that SA/PEI hydrogel has great potential in practical seawater application.
Keyword ：
Biosorbent Biosorbent Sodium alginate/polyethyleneimine Sodium alginate/polyethyleneimine Uranium (VI) extraction Uranium (VI) extraction
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| GB/T 7714 | Huang, Zhixuan , Li, Wanying , Xu, Suyan et al. A novel sponge-like composite biosorbent fabricated by sodium alginate and polyethyleneimine for uranium(VI) extraction from seawater [J]. | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES , 2024 , 279 . |
| MLA | Huang, Zhixuan et al. "A novel sponge-like composite biosorbent fabricated by sodium alginate and polyethyleneimine for uranium(VI) extraction from seawater" . | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 279 (2024) . |
| APA | Huang, Zhixuan , Li, Wanying , Xu, Suyan , Xu, Xiaoping , Ou, Minrui . A novel sponge-like composite biosorbent fabricated by sodium alginate and polyethyleneimine for uranium(VI) extraction from seawater . | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES , 2024 , 279 . |
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In this work, we synthesized a novel beta-cyclodextrin/poly(2-acrylamide-2-methylpropionic acid)/attapulgite (CAMA) hydrogel for uranium(VI) adsorption. Various instrumental techniques such as FTIR, SEM, EDX, and TGA were utilized for characterization of the CAMA. Simultaneously, different important parameters, in specific pH, time, initial uranyl ion concentration and temperature were investigated to evaluate the optimal conditions of the adsorption process. The experiments proofs that the adsorption follows the pseudo-second-order kinetic model so as the Langmuir model, and revealed the maximum adsorption capacity of 434.78 mg g(-1) at 298.15 K. Regeneration studies further sighted out the good reusability of the synthesized CAMA hydrogel.
Keyword ：
Adsorption U(VI) Adsorption U(VI) Attapulgite Attapulgite beta-cyclodextrin beta-cyclodextrin Poly(2-acrylamide-2-methylpropionic acid) Poly(2-acrylamide-2-methylpropionic acid)
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| GB/T 7714 | Ou, Minrui , Li, Wanying , Zhang, Zihui et al. Adsorption of uranium(VI) with a novel AMPS-modified thermostable beta-cyclodextrin biosorbent [J]. | JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY , 2023 , 332 (1) : 23-32 . |
| MLA | Ou, Minrui et al. "Adsorption of uranium(VI) with a novel AMPS-modified thermostable beta-cyclodextrin biosorbent" . | JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY 332 . 1 (2023) : 23-32 . |
| APA | Ou, Minrui , Li, Wanying , Zhang, Zihui , Xu, Xiaoping . Adsorption of uranium(VI) with a novel AMPS-modified thermostable beta-cyclodextrin biosorbent . | JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY , 2023 , 332 (1) , 23-32 . |
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Extracting uranium from seawater is of great significance for ensuring the sustainable development of nuclear energy. This article designs a simple and mass-produced porous sponge polyamidoxime/polyethyleneimine (PAO/PEI) for uranium extraction from seawater. The prepared porous sponge has excellent flexibility and mechanical strength, which can withstand harsh marine environments. In a 50 mg/L uranyl solution, the maximum adsorption capacity of PAO/PEI is 666.67 mg/g. Moreover, PAO/PEI sponge exhibits excellent selectivity for uranium in competitive adsorption conditions. FTIR and XPS are used to explore the adsorption mechanism, and the results showed that the synergistic effect of amidoxime and amino groups enhanced the binding of uranium(VI). The adsorption capacity after 15 days of enrichment in 100L natural seawater is 9.79 mg/g, and the average rate is 0.653 mg/g/day. The results indicate that PAO/PEI porous sponge has broad application prospects in large-scale seawater uranium(VI) extraction.
Keyword ：
Adsorption mechanism Adsorption mechanism Polyamidoxime/polyethyleneimine Polyamidoxime/polyethyleneimine Seawater Seawater Uranium(VI) extraction Uranium(VI) extraction
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| GB/T 7714 | Ou, Minrui , Li, Wanying , Huang, Zhixuan et al. Highly efficient extraction of uranium(VI) from seawater by polyamidoxime/polyethyleneimine sponge [J]. | SEPARATION AND PURIFICATION TECHNOLOGY , 2023 , 331 . |
| MLA | Ou, Minrui et al. "Highly efficient extraction of uranium(VI) from seawater by polyamidoxime/polyethyleneimine sponge" . | SEPARATION AND PURIFICATION TECHNOLOGY 331 (2023) . |
| APA | Ou, Minrui , Li, Wanying , Huang, Zhixuan , Xu, Xiaoping . Highly efficient extraction of uranium(VI) from seawater by polyamidoxime/polyethyleneimine sponge . | SEPARATION AND PURIFICATION TECHNOLOGY , 2023 , 331 . |
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Abstract ：
The separation and enrichment of uranium from various resources such as seawater is of great significance to the sustainable development of nuclear energy. Therefore, there is an urgent need to develop an adsorbent with low cost and easy availability, simple preparation process, and environment friendly. In this work, we used inexpensive natural polymer material (sodium alginate) and natural adsorbents (beta-cyclodextrin and diatomite) to prepare a novel biosorbent beta-cyclodextrin/sodium alginate/diatomite (CSD) hydrogel beads for uranium adsorption by a simple method. The results of FTIR, XRD, SEM, EDX and XPS characterization proved that the CSD were prepared. Static adsorption experiments showed that pH, contact time, initial concentration of U(VI) and temperature has significant impact on the adsorption capacity of CSD. Adsorption fitted the pseudo-second-order kinetic model and Langmuir model and the adsorption mechanism is chemical adsorption. In the presence of other metal ions (Cu2+, Mg2+, Ca2+, Na+, K+), CSD has obvious selectivity for uranium(VI) adsorption. In addition, the elution and reusability studies show that CSD has excellent reusability. Overall, CSD is an inexpensive, green preparation, efficient, and environment friendly biosorbent with obvious selectivity for U(VI). It has potential application in U(VI) enrichment from seawater or salt lake water.
Keyword ：
beta-Cyclodextrin/sodium alginate/diatomite beta-Cyclodextrin/sodium alginate/diatomite Biosorbent Biosorbent Uranium(VI) adsorption Uranium(VI) adsorption
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| GB/T 7714 | Ou, Minrui , Li, Wanying , Zhang, Zihui et al. beta-Cyclodextrin and diatomite immobilized in sodium alginate biosorbent for selective uranium(VI) adsorption in aqueous solution [J]. | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES , 2022 , 222 : 2006-2016 . |
| MLA | Ou, Minrui et al. "beta-Cyclodextrin and diatomite immobilized in sodium alginate biosorbent for selective uranium(VI) adsorption in aqueous solution" . | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 222 (2022) : 2006-2016 . |
| APA | Ou, Minrui , Li, Wanying , Zhang, Zihui , Xu, Xiaoping . beta-Cyclodextrin and diatomite immobilized in sodium alginate biosorbent for selective uranium(VI) adsorption in aqueous solution . | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES , 2022 , 222 , 2006-2016 . |
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There are currently many materials for treating residual antibiotics in the environment, but none of them can specifically remove antibiotics. In addition, these materials are not sensitive enough to low concentrations of antibiotics. Here we show that a sensitive and specific material was developed by the preparation of magnetic Fe3O4-PAMAM-antibody complexes for treating tetracycline. The prepared antibody complexes can specifically treat tetracycline from aqueous solutions and the tetracycline removal ability by adsorption was also investigated. Controlled experiments were carried out with the effects of solution pH, temperature, and initial concentration of the tetracycline. The tetracycline was completely removed within 35 min at room temperature 30 degrees C with the maximum removal rate of almost 100%. Therefore, this material for specifically combining antigen and antibody to treat tetracycline indicated good application prospects for the waste water treatment.
Keyword ：
antibody antibody complex material complex material specificity specificity tetracycline tetracycline water treatment water treatment
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| GB/T 7714 | Ou Min-Rui , Zhang Zi-Hui , Wen Yu-Kai et al. A Sensitive Material for Specifically Treating Tetracycline in Water Environment [J]. | CHINESE JOURNAL OF STRUCTURAL CHEMISTRY , 2021 , 40 (5) : 646-652 . |
| MLA | Ou Min-Rui et al. "A Sensitive Material for Specifically Treating Tetracycline in Water Environment" . | CHINESE JOURNAL OF STRUCTURAL CHEMISTRY 40 . 5 (2021) : 646-652 . |
| APA | Ou Min-Rui , Zhang Zi-Hui , Wen Yu-Kai , Xu Xiao-Ping , Yang Huang-Hao . A Sensitive Material for Specifically Treating Tetracycline in Water Environment . | CHINESE JOURNAL OF STRUCTURAL CHEMISTRY , 2021 , 40 (5) , 646-652 . |
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Uranium in the environment can damage human health and ecosystem. There is a need for excellent adsorbents to remove U(VI) from aqueous solutions. Here we synthesized a novel beta-cyclodextrin/poly(acrylic acid)/permutite (CAP) hydrogel composite by a simple method. Physicochemical characterizations of the materials were conducted by XRD, FTIR, SEM, EDX, and TGA. The effect of pH value, contact time, initial U(VI) concentration, and temperature were researched. A pseudo-second-order kinetic model, intra-particle diffusion model, and Langmuir isotherm model were used to describe the U(VI) adsorption behavior, and the maximum adsorption capacity of U(VI) was 833.33 mg/g at 25 C. Thermodynamic analysis showed that the adsorption process of U(VI) was endothermic and spontaneous. Furthermore, the excellent reusability indicated that CAP hydrogel composite could be potentially used as a promising sorbent for the removal of U (VI) in wastewater.
Keyword ：
acrylic acid acrylic acid adsorption adsorption beta-cyclodextrin beta-cyclodextrin hydrogel hydrogel U(VI) U(VI)
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| GB/T 7714 | Zhang Zi-Hui , Zhang Wen , Xu Xiao-Ping et al. Preparation and Characterization of beta-Cyclodextrin/Poly(acrylic acid)/Permutite Hydrogel Composite for U(VI) Adsorption [J]. | CHINESE JOURNAL OF STRUCTURAL CHEMISTRY , 2020 , 39 (10) : 1795-1806 . |
| MLA | Zhang Zi-Hui et al. "Preparation and Characterization of beta-Cyclodextrin/Poly(acrylic acid)/Permutite Hydrogel Composite for U(VI) Adsorption" . | CHINESE JOURNAL OF STRUCTURAL CHEMISTRY 39 . 10 (2020) : 1795-1806 . |
| APA | Zhang Zi-Hui , Zhang Wen , Xu Xiao-Ping , Ou Min-Rui . Preparation and Characterization of beta-Cyclodextrin/Poly(acrylic acid)/Permutite Hydrogel Composite for U(VI) Adsorption . | CHINESE JOURNAL OF STRUCTURAL CHEMISTRY , 2020 , 39 (10) , 1795-1806 . |
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Antigens and antibodies can bind specifically, so antibiotic antibody shows potential biological and environmental applications on the removal of antibiotic. In the present study, novel antibody complex was synthesized from polyamide-amine dendrimer immobilized tetracycline (TC) antibody with the encapsulation of magnetic Fe3O4 nanoparticles. As-prepared magnetic Fe3O4-PAMAM-antibody complexes were characterized by different techniques such as Fourier transform infrared (FT-IR), X-ray diffraction (XRD), Nuclear magnetic resonance (NMR) and ultraviolet (UV) analysis spectra. The prepared antibody complexes exhibited high adsorption properties for TC from aqueous solutions. These results suggest that the antibody complex expects to be a potential candidate for the wastewater treatment.
Keyword ：
antibody complex antibody complex magnetic Fe3O4 magnetic Fe3O4 PAMAM PAMAM tetracycline tetracycline
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| GB/T 7714 | Ou Min-Rui , Zhang Zi-Hui , Chen Zhi-Hong et al. Preparation and Characterization of Magnetic Fe3O4-PAMAM-antibody Complex and Its Application in the Removal of Tetracycline from Wastewater [J]. | CHINESE JOURNAL OF STRUCTURAL CHEMISTRY , 2019 , 38 (7) : 1136-1145 . |
| MLA | Ou Min-Rui et al. "Preparation and Characterization of Magnetic Fe3O4-PAMAM-antibody Complex and Its Application in the Removal of Tetracycline from Wastewater" . | CHINESE JOURNAL OF STRUCTURAL CHEMISTRY 38 . 7 (2019) : 1136-1145 . |
| APA | Ou Min-Rui , Zhang Zi-Hui , Chen Zhi-Hong , Wen Yu-Kai , Yang Huang-Hao , Xu Xiao-Ping . Preparation and Characterization of Magnetic Fe3O4-PAMAM-antibody Complex and Its Application in the Removal of Tetracycline from Wastewater . | CHINESE JOURNAL OF STRUCTURAL CHEMISTRY , 2019 , 38 (7) , 1136-1145 . |
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In this work, novel nanocomposite beads based on polyvinyl alcohol (PVA) coated polyacrylonitrile (PAN) with encapsulation of TiO2 nanoparticles (PPT) were developed successfully via a novel green synthetic method and its methylene blue (MB) removal ability by adsorption was also investigated. As-prepared nanocomposite beads were characterized by different techniques such as Fourier transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD), scanning electron microscopy (SEM) and thermogmvimetric analysis (TGA). TiO2 nanoparticles were encapsulated into the composite beads to endow the composite beads with photocatalytic ability and enhance its adsorption capacity for MB. Batch experiments with several variables such as TiO2 nanoparticle content, pH of the solution, contact time and initial MB concentration were carried out. The adsorption kinetic study revealed that the MB adsorption process agreed well with pseudo-second order model and showed 3-stage intraparticle diffusion model. The adsorption isotherm study indicated that the MB adsorption process could also be better described by Langmuir isotherm model. According to Langmuir isotherm equation, the maximum adsorption capacity and removal rate for MB was 242.13 mg g(-1) and 98.4%, respectively. Moreover, the stability and reusability of as-prepared PPT beads were further explored and results demonstrated that PPT could be reused at least five times with negligible loss of sorption capacity and removal rate. Therefore. PPT is expected to be a potential candidate for effluents treatment.
Keyword ：
methylene blue methylene blue nano titanium dioxide nano titanium dioxide polyacrylonitrile polyacrylonitrile polyvinyl alcohol polyvinyl alcohol
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| GB/T 7714 | Han, Zhenhua , Jin, Jiali , Wang, Yuchao et al. Encapsulating TiO2 into Polyvinyl Alcohol Coated Polyacrylonitrile Composite Beads for the Effective Removal of Methylene Blue [J]. | JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY , 2019 , 30 (2) : 211-223 . |
| MLA | Han, Zhenhua et al. "Encapsulating TiO2 into Polyvinyl Alcohol Coated Polyacrylonitrile Composite Beads for the Effective Removal of Methylene Blue" . | JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY 30 . 2 (2019) : 211-223 . |
| APA | Han, Zhenhua , Jin, Jiali , Wang, Yuchao , Zhang, Zihui , Gu, Junjie , Ou, Minrui et al. Encapsulating TiO2 into Polyvinyl Alcohol Coated Polyacrylonitrile Composite Beads for the Effective Removal of Methylene Blue . | JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY , 2019 , 30 (2) , 211-223 . |
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