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author:

Hong, RuChen (Hong, RuChen.) [1] | Lai, Jun (Lai, Jun.) [2] | Mai, DongYi (Mai, DongYi.) [3] | Li, Lan (Li, Lan.) [4] | Dai, LiJun (Dai, LiJun.) [5] | Lu, YanJin (Lu, YanJin.) [6] | Lin, JinXin (Lin, JinXin.) [7]

Indexed by:

EI Scopus SCIE

Abstract:

In the realm of skin injury management, the expedited closure of wounds, prevention of scar formation, and enhancement of the healing process are of critical significance. The creation of economical dressings that effectively facilitate swift wound sealing in the initial phase of skin trauma while curbing scar development represents a promising avenue for clinical utility. Within the context of this investigation, we synthesized a novel hydrogel composed of chitosan (CS), carboxylated poly(vinyl alcohol) (PVA-COOH) via a Schiff base reaction between carboxylated PVA and chitosan, yielding networks abundant in amide bonds. Following this, a chitosan/ carboxylated PVA/poly(N-isopropylacrylamide) hydrogel (CNP) was engineered by incorporating poly-N-isopropylacrylamide chains for interpenetration at ambient temperature. Our findings indicate that the CNP hydrogel exhibits favorable degradability and swelling characteristics. Moreover, it possesses favorable antimicrobial efficacy and biocompatibility. In a murine full-thickness skin injury model, the hydrogel was found to expedite wound healing by augmenting granulation tissue formation, mitigating wound inflammation, and promoting angiogenesis.

Keyword:

Antibacterial hydrogel Chitosan Promote wound healing

Community:

  • [ 1 ] [Hong, RuChen]Fuzhou Univ, Coll Chem, Fuzhou 350108, Fujian, Peoples R China
  • [ 2 ] [Lai, Jun]Fuzhou Univ, Coll Chem, Fuzhou 350108, Fujian, Peoples R China
  • [ 3 ] [Dai, LiJun]Fuzhou Univ, Coll Chem, Fuzhou 350108, Fujian, Peoples R China
  • [ 4 ] [Hong, RuChen]Chinese Acad Sci, Fujian Inst Res Struct Matter, Key Lab Optoelect Mat Chem & Phys, Fuzhou 350002, Peoples R China
  • [ 5 ] [Lai, Jun]Chinese Acad Sci, Fujian Inst Res Struct Matter, Key Lab Optoelect Mat Chem & Phys, Fuzhou 350002, Peoples R China
  • [ 6 ] [Mai, DongYi]Chinese Acad Sci, Fujian Inst Res Struct Matter, Key Lab Optoelect Mat Chem & Phys, Fuzhou 350002, Peoples R China
  • [ 7 ] [Li, Lan]Chinese Acad Sci, Fujian Inst Res Struct Matter, Key Lab Optoelect Mat Chem & Phys, Fuzhou 350002, Peoples R China
  • [ 8 ] [Dai, LiJun]Chinese Acad Sci, Fujian Inst Res Struct Matter, Key Lab Optoelect Mat Chem & Phys, Fuzhou 350002, Peoples R China
  • [ 9 ] [Lin, JinXin]Chinese Acad Sci, Fujian Inst Res Struct Matter, Key Lab Optoelect Mat Chem & Phys, Fuzhou 350002, Peoples R China
  • [ 10 ] [Lin, JinXin]Fujian Sci & Technol Innovat Lab Optoelect Informa, Fuzhou 350108, Fujian, Peoples R China
  • [ 11 ] [Mai, DongYi]Fujian Normal Univ, Coll Optoelect & Elect Engn, Coll Chem & Mat Sci, Fuzhou 350117, Peoples R China
  • [ 12 ] [Lu, YanJin]Fujian Normal Univ, Coll Optoelect & Elect Engn, Coll Chem & Mat Sci, Fuzhou 350117, Peoples R China

Reprint 's Address:

  • [Lin, JinXin]Chinese Acad Sci, Fujian Inst Res Struct Matter, Key Lab Optoelect Mat Chem & Phys, Fuzhou 350002, Peoples R China;;[Lu, YanJin]Fujian Normal Univ, Coll Optoelect & Elect Engn, Coll Chem & Mat Sci, Fuzhou 350117, Peoples R China;;

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Source :

BIOMATERIALS ADVANCES

Year: 2024

Volume: 166

5 . 5 0 0

JCR@2023

Cited Count:

WoS CC Cited Count:

SCOPUS Cited Count:

ESI Highly Cited Papers on the List: 0 Unfold All

WanFang Cited Count:

Chinese Cited Count:

30 Days PV: 0

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