In　the　realm　of　skin　injury　management,　the　expedited　closure　of　wounds,　prevention　of　scar　formation,　and　enhancement　of　the　healing　process　are　of　critical　significance.　The　creation　of　economical　dressings　that　effectively　facilitate　swift　wound　sealing　in　the　initial　phase　of　skin　trauma　while　curbing　scar　development　represents　a　promising　avenue　for　clinical　utility.　Within　the　context　of　this　investigation,　we　synthesized　a　novel　hydrogel　composed　of　chitosan　(CS),　carboxylated　poly(vinyl　alcohol)　(PVA-COOH)　via　a　Schiff　base　reaction　between　carboxylated　PVA　and　chitosan,　yielding　networks　abundant　in　amide　bonds.　Following　this,　a　chitosan/carboxylated　PVA/poly(N-isopropylacrylamide)　hydrogel　(CNP)　was　engineered　by　incorporating　poly-N-isopropylacrylamide　chains　for　interpenetration　at　ambient　temperature.　Our　findings　indicate　that　the　CNP　hydrogel　exhibits　favorable　degradability　and　swelling　characteristics.　Moreover,　it　possesses　favorable　antimicrobial　efficacy　and　biocompatibility.　In　a　murine　full-thickness　skin　injury　model,　the　hydrogel　was　found　to　expedite　wound　healing　by　augmenting　granulation　tissue　formation,　mitigating　wound　inflammation,　and　promoting　angiogenesis.　©　2024　Elsevier　B.V.