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author:

Xu, Gan (Xu, Gan.) [1] | Xu, Na (Xu, Na.) [2] | Ren, Tingjie (Ren, Tingjie.) [3] | Chen, Changyou (Chen, Changyou.) [4] | Li, Jiangfeng (Li, Jiangfeng.) [5] | Ding, Liangping (Ding, Liangping.) [6] | Chen, Yang (Chen, Yang.) [7] | Chen, Guoqiang (Chen, Guoqiang.) [8] | Li, Zheng (Li, Zheng.) [9] | Yu, Yunlong (Yu, Yunlong.) [10]

Indexed by:

SCIE

Abstract:

Wound dressing is a kind of significant artificial materials for protecting injured tissues and promoting wound healing. However, fabrication of antibacterial wound dressing usually involves tedious procedures and toxic components. Herein, we demonstrate a multifunctional chitosan/silver/tannic acid (CS/Ag/TA) cryogel based on an economic method to block acute hemorrhage and promote wound healing. The prepared CS/Ag/TA cryogel not only performs steady stability and compressibility, but also shows good antibacterial ability for both S. aureus and E. coli. Attributing to TA molecules, the CS/Ag/TA cryogel can effectively scavenge more than 95% of free radicals, showing effective oxidation resistance. Due to the porous structure and positive charge of CS, the prepared cryogel exhibits good hemostatic capability with a hemostasis time less than 20 s. Benefitting from the good biocompatibility and cell proliferation, the CS/Ag/TA cryogel can significantly promote wound repair in the skin incision model. All the results indicated that the greenly fabricated cryogel can be widely applied in clinic for hemostasis and wound healing.

Keyword:

Chitosan Cryogel Wound healing

Community:

  • [ 1 ] [Xu, Gan]Third Mil Med Univ, Southwest Hosp, Inst Burn Res, Army Med Univ, Chongqing 400038, Peoples R China
  • [ 2 ] [Xu, Na]Third Mil Med Univ, Southwest Hosp, Inst Burn Res, Army Med Univ, Chongqing 400038, Peoples R China
  • [ 3 ] [Chen, Changyou]Third Mil Med Univ, Southwest Hosp, Inst Burn Res, Army Med Univ, Chongqing 400038, Peoples R China
  • [ 4 ] [Li, Jiangfeng]Third Mil Med Univ, Southwest Hosp, Inst Burn Res, Army Med Univ, Chongqing 400038, Peoples R China
  • [ 5 ] [Ding, Liangping]Third Mil Med Univ, Southwest Hosp, Inst Burn Res, Army Med Univ, Chongqing 400038, Peoples R China
  • [ 6 ] [Li, Zheng]Third Mil Med Univ, Southwest Hosp, Inst Burn Res, Army Med Univ, Chongqing 400038, Peoples R China
  • [ 7 ] [Yu, Yunlong]Third Mil Med Univ, Southwest Hosp, Inst Burn Res, Army Med Univ, Chongqing 400038, Peoples R China
  • [ 8 ] [Xu, Gan]Fuzhou Univ, Coll Biol Sci & Engn, Fuzhou 350002, Peoples R China
  • [ 9 ] [Ren, Tingjie]Sun Yat Sen Univ, Dept Arthrosteoped Surg, Peoples Hosp Foshan 1, Foshan 528000, Guangdong, Peoples R China
  • [ 10 ] [Chen, Yang]Sun Yat Sen Univ, Dept Arthrosteoped Surg, Peoples Hosp Foshan 1, Foshan 528000, Guangdong, Peoples R China
  • [ 11 ] [Chen, Guoqiang]Sun Yat Sen Univ, Dept Arthrosteoped Surg, Peoples Hosp Foshan 1, Foshan 528000, Guangdong, Peoples R China
  • [ 12 ] [Ren, Tingjie]Sun Yat Sen Univ, Foshan Hosp, Foshan 528000, Guangdong, Peoples R China
  • [ 13 ] [Chen, Yang]Sun Yat Sen Univ, Foshan Hosp, Foshan 528000, Guangdong, Peoples R China
  • [ 14 ] [Chen, Guoqiang]Sun Yat Sen Univ, Foshan Hosp, Foshan 528000, Guangdong, Peoples R China

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Source :

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

ISSN: 0141-8130

Year: 2022

Volume: 208

Page: 760-771

8 . 2

JCR@2022

7 . 7 0 0

JCR@2023

ESI Discipline: BIOLOGY & BIOCHEMISTRY;

ESI HC Threshold:60

JCR Journal Grade:1

CAS Journal Grade:1

Cited Count:

WoS CC Cited Count: 18

SCOPUS Cited Count: 19

ESI Highly Cited Papers on the List: 0 Unfold All

WanFang Cited Count:

Chinese Cited Count:

30 Days PV: 2

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