A　novel　molecularly　imprinted　polymer-coated　polypropylene　hollow　fiber　tube　(MIP-HFT)　was　photoinitiated　for　the　copolymerization　of　diethylstilbestrol　(DES)　as　a　template　molecule,　alpha-methacrylic　acid　as　a　functional　monomer,　and　ethylene　glycol　dimethacrylate　as　a　crosslinking　agent.　The　characteristics　and　applications　of　the　MIP-HFT　were　investigated.　In　order　to　compare　its　characteristics　with　those　of　a　non-imprinted　polymer-immersed　hollow　fiber　tube,　the　selectivity　of　the　MIP-HFT　was　investigated　using　dienestrol　and　hexestrol　as　the　structural　analogues　of　a　DES　template.　and　phenol　and　methylbenzene　were　taken　as　reference　compounds.　The　MIP-HFT　was　employed　in　the　HPLC　analysis　of　spiked　milk　samples.　The　detection　limits　of　the　method　were　found　to　be　in　the　range　2.5-3.3　mu　g　L-1　for　DES,　dienestrol　and　hexestrol　and　the　RSD%　were　in　the　range　6.4-8.9.　The　limits　of　quantitation　were　found　to　be　in　the　range　8.7-9.4　mu　g　L-1　in　milk　for　DES,　dienestrol　and　hexestrol,　and　their　average　recoveries　were　83.7-90.6%　in　the　spiked　milk　samples.　The　experimental　results　revealed　that　the　MIP-HFT　provides　a　good　carrier　for　the　selective　adsorption　of　DES　and　its　chemical　structure　analogs,　and　can　be　used　for　the　preconcentration　of　these　compounds　in　complicated　samples.　(C)　2010　Elsevier　B.V.　All　rights　reserved.