A　novel　molecularly　imprinted　polymer-coated　polypropylene　hollow　fiber　tube　(MIP-HFT)　was　photoinitiated　for　the　copolymerization　of　diethylstilbestrol　(DES)　as　a　template　molecule,　α-methacrylic　acid　as　a　functional　monomer,　and　ethylene　glycol　dimethacrylate　as　a　crosslinking　agent.　The　characteristics　and　applications　of　the　MIP-HFT　were　investigated.　In　order　to　compare　its　characteristics　with　those　of　a　non-imprinted　polymer-immersed　hollow　fiber　tube,　the　selectivity　of　the　MIP-HFT　was　investigated　using　dienestrol　and　hexestrol　as　the　structural　analogues　of　a　DES　template,　and　phenol　and　methylbenzene　were　taken　as　reference　compounds.　The　MIP-HFT　was　employed　in　the　HPLC　analysis　of　spiked　milk　samples.　The　detection　limits　of　the　method　were　found　to　be　in　the　range　2.5-3.3μgL-1　for　DES,　dienestrol　and　hexestrol　and　the　RSD%　were　in　the　range　6.4-8.9.　The　limits　of　quantitation　were　found　to　be　in　the　range　8.7-9.4μgL-1　in　milk　for　DES,　dienestrol　and　hexestrol,　and　their　average　recoveries　were　83.7-90.6%　in　the　spiked　milk　samples.　The　experimental　results　revealed　that　the　MIP-HFT　provides　a　good　carrier　for　the　selective　adsorption　of　DES　and　its　chemical　structure　analogs,　and　can　be　used　for　the　preconcentration　of　these　compounds　in　complicated　samples.　©　2010　Elsevier　B.V.