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学者姓名：李梅金
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Abstract ：
The judicious utilization of antibiotics has established a robust bulwark for human health. However, their improper usage has engendered deleterious ramifications on the environment, underscoring the imperative for developing efficacious and cost-effective detection and degradation platforms. This study presents a sulfur-modified iron-cobalt bimetallic single-atom nitrogen-doped carbon catalyst (S-FeCo-NC) with a noncopper active center. In contrast to conventional laccase, which utilizes copper as its active center, the S-FeCo-NC catalyst exhibits multiple enzyme activities, including laccase-like, peroxidase-like, and catalase-like functions, with iron and cobalt serving as the active centers. As a proof of concept, the combined laccase-like and catalase-like functions of S-FeCo-NC were used as independent signal outputs, while a multienzyme cascade dual-mode assay system was designed for the rapid detection of tetracycline (TC) in combination with peroxidase-like enzymes. In this system, oxygen directly participated in the catalytic process of laccase-like as an electron acceptor, while catalase-like peroxidase efficiently catalyzed the production of O2 from H2O2. The elevated concentration of O2 offered a unique advantage for the increased catalytic activity of the laccase-like enzyme, which outputs visually resolved colorimetric signals using stable 4-aminopyridine with oxidized TC. Furthermore, the peroxidase-like activity of S-FeCo-NC catalyzed the generation of OH radicals with strong oxidative properties, and these radicals carried out effective oxidative decomposition of TC. The signal output of the response of the catalytic process was performed using differential pulse cyclic voltammetry, which further improved the sensitivity and accuracy of the detection. The experimental findings demonstrate that the detection system exhibits a favorable response signal to TC within the range of 0.005-500 mu M, with its detection range reaching 0.5-500 and 0.005-1.00 mu M, respectively, and the detection limit is as low as 0.22 mu M and 1.68 nM, respectively. This cascade dual-mode detection system, based on multienzyme activity, has been shown to significantly enhance the catalytic activity of laccase, while also demonstrating stability in a lower detection range. This suggests that it may offer a novel approach for the sensitive detection and degradation of environmental pollutants.
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| GB/T 7714 | Wang, Yunsen , Tian, Shuo , Chen, Shuyun et al. S-Modified MOF Nanozyme Cascade System with Multi-Enzyme Activity for Dual-Mode Antibiotic Assay [J]. | ANALYTICAL CHEMISTRY , 2025 , 97 (13) : 7526-7535 . |
| MLA | Wang, Yunsen et al. "S-Modified MOF Nanozyme Cascade System with Multi-Enzyme Activity for Dual-Mode Antibiotic Assay" . | ANALYTICAL CHEMISTRY 97 . 13 (2025) : 7526-7535 . |
| APA | Wang, Yunsen , Tian, Shuo , Chen, Shuyun , Li, Meijin , Tang, Dianping . S-Modified MOF Nanozyme Cascade System with Multi-Enzyme Activity for Dual-Mode Antibiotic Assay . | ANALYTICAL CHEMISTRY , 2025 , 97 (13) , 7526-7535 . |
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Abstract ：
1.“correlation coefficient” in abstract (line 9) and page 6,column 1, last paragraph (line 8) should be changed to “coefficient of determination ". 2.“pDNA” in page 3, column 2, section 2.3 (line 8) should be changed to “probe DNA (pDNA)". 3."cDNA” in page 4, column 1, line 1 should be changed to “complementary DNA (cDNA)" The authors would like to apologise for any inconvenience caused. © 2023 Elsevier B.V.
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| GB/T 7714 | Zheng, K. , Pan, J. , Yu, Z. et al. Corrigendum to “A smartphone-assisted electrochemiluminescent detection of miRNA-21 in situ using Ru(bpy)32+@MOF” [Talanta 258 (2024)125310] (Talanta (2024) 268(P1), (S0039914023010615), (10.1016/j.talanta.2023.125310)) [未知]. |
| MLA | Zheng, K. et al. "Corrigendum to “A smartphone-assisted electrochemiluminescent detection of miRNA-21 in situ using Ru(bpy)32+@MOF” [Talanta 258 (2024)125310] (Talanta (2024) 268(P1), (S0039914023010615), (10.1016/j.talanta.2023.125310))" [未知]. |
| APA | Zheng, K. , Pan, J. , Yu, Z. , Yi, C. , Li, M.-J. . Corrigendum to “A smartphone-assisted electrochemiluminescent detection of miRNA-21 in situ using Ru(bpy)32+@MOF” [Talanta 258 (2024)125310] (Talanta (2024) 268(P1), (S0039914023010615), (10.1016/j.talanta.2023.125310)) [未知]. |
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Photodynamic therapy is an emerging tumor therapy that kills tumor cells by activating reactive oxygen species (ROS) produced by photosensitizers. Mitochondria, as an important organelle, are the main generator of cellular ROS. Therefore, the development of photosensitizers capable of targeting mitochondria could significantly enhance the efficacy of photodynamic therapy. In this study, two novel ruthenium(ii) complexes, Ru-1 and Ru-2, were designed and synthesized, both of which were functionalized with alpha,beta-unsaturated ketones for sensing of glutathione (GSH). The crystal structures of the two complexes were determined and they exhibited good recognition of GSH by off-on luminescence signals. The complex Ru-2 containing aromatic naphthalene can enter the cells and react with GSH to generate a strong luminescence signal that can be used to monitor intracellular GSH levels through imaging. Ru-2 also has an excellent mitochondrial localization ability with a Pearson's coefficient of 0.95, which demonstrates that it can efficiently target the mitochondria of tumor cells to enhance the effectiveness of photodynamic therapy as a photosensitizer.
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| GB/T 7714 | Zhang, Wanqing , Chen, Weibin , Fu, Fengfu et al. Mitochondria-targeted ruthenium(ii) complexes for photodynamic therapy and GSH detection in living cells [J]. | DALTON TRANSACTIONS , 2024 , 53 (13) : 5957-5965 . |
| MLA | Zhang, Wanqing et al. "Mitochondria-targeted ruthenium(ii) complexes for photodynamic therapy and GSH detection in living cells" . | DALTON TRANSACTIONS 53 . 13 (2024) : 5957-5965 . |
| APA | Zhang, Wanqing , Chen, Weibin , Fu, Fengfu , Li, Mei-Jin . Mitochondria-targeted ruthenium(ii) complexes for photodynamic therapy and GSH detection in living cells . | DALTON TRANSACTIONS , 2024 , 53 (13) , 5957-5965 . |
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A smartphone-assisted electrochemiluminescence (ECL) strategy based on Ru(bpy)2(L)4+ as chromophores confined with metal − organic frameworks (Ru(bpy)2(L)4+@MOF-5) for the signal-amplified detection of miRNA-21 was developed. We synthesized a derivative of tris(2,2’-bipyridyl)ruthenium(II) complex (Ru(bpy)2(L)4+) with high charges, which can be loaded into the MOF-5 by strong electrostatic interaction to prevent from leakage. In addition, nucleic acid cycle amplification was used to quench the signal of Ru(bpy)2(L)4+@MOF-5 by ferrocene. This method was applied to detect the concentration of miRNA-21 ranging from 1.0 × 10−14-1.0 × 10−9 M with a low LOD of 7.2 fM. This work demonstrated the construction of a signal quenching strategy ECL biosensor for miRNA using Ru(bpy)2(L)4+@MOF-5 systems and its application in smartphone-assisted ECL detection. Graphical abstract: (Figure presented.) © The Author(s), under exclusive licence to Springer-Verlag GmbH Austria, part of Springer Nature 2024.
Keyword ：
Electrochemiluminescence Electrochemiluminescence MicroRNA MicroRNA MOF-5 MOF-5 Ru(II) complex Ru(II) complex Signal amplification Signal amplification Smartphone-assisted detection Smartphone-assisted detection
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| GB/T 7714 | Zheng, K. , Zheng, Q. , Mu, X. et al. A smartphone-assisted electrochemiluminescent biosensor for highly sensitive detection of miRNA-21 based on Ru(bpy)2(L)4+@MOF-5 [J]. | Microchimica Acta , 2024 , 191 (10) . |
| MLA | Zheng, K. et al. "A smartphone-assisted electrochemiluminescent biosensor for highly sensitive detection of miRNA-21 based on Ru(bpy)2(L)4+@MOF-5" . | Microchimica Acta 191 . 10 (2024) . |
| APA | Zheng, K. , Zheng, Q. , Mu, X. , Li, M.-J. , Yi, C. . A smartphone-assisted electrochemiluminescent biosensor for highly sensitive detection of miRNA-21 based on Ru(bpy)2(L)4+@MOF-5 . | Microchimica Acta , 2024 , 191 (10) . |
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| GB/T 7714 | Zheng, Kai , Pan, Jiangfei , Yu, Zipei et al. A smartphone-assisted electrochemiluminescent detection of miRNA-21 in situ using Ru(bpy)32+@MOF ( vol 258, 125310, 2024) [J]. | TALANTA , 2024 , 269 . |
| MLA | Zheng, Kai et al. "A smartphone-assisted electrochemiluminescent detection of miRNA-21 in situ using Ru(bpy)32+@MOF ( vol 258, 125310, 2024)" . | TALANTA 269 (2024) . |
| APA | Zheng, Kai , Pan, Jiangfei , Yu, Zipei , Yi, Changqing , Li, Mei-Jin . A smartphone-assisted electrochemiluminescent detection of miRNA-21 in situ using Ru(bpy)32+@MOF ( vol 258, 125310, 2024) . | TALANTA , 2024 , 269 . |
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The proof-of-concept of sensitive electrochemical immunoassay for the quantitative monitoring of human epidermal growth factor receptor 2 (HER2) is reported. The assay is carried out on iron nitrogen-doped carbon (FeNC) nanozyme-modified screen-printed carbon electrode using chronoamperometry. Introduction of target HER2 can induce the sandwiched immunoreaction between anti-HER2 monoclonal antibody-coated microplate and biotinylated anti-HER2 polyclonal antibody. Thereafter, streptavidin-glucose oxidase (GOx) conjugate is bonded to the detection antibody. Upon addition of glucose, 3,3 & PRIME;,5,5 & PRIME;-tetramethylbenzidine (TMB) is oxidized through the produced H2O2 with the assistance of GOx and FeNC nanozyme. The oxidized TMB is determined via chronoamperometry. Experimental results revealed that electrochemical immunosensing system exhibited good amperometric response, and allowed the detection of target HER2 as low as 4.5 pg/mL. High specificity and long-term stability are acquired with FeNC nanozyme-based sensing strategy. Importantly, our system provides a new opportunity for protein diagnostics.
Keyword ：
Chronoamperometry Chronoamperometry Electrochemical immunoassay Electrochemical immunoassay Human epidermal growth factor receptor 2 Human epidermal growth factor receptor 2 Iron nitrogen-doped carbon Iron nitrogen-doped carbon Nanozyme Nanozyme
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| GB/T 7714 | Qiu, Minghao , Ren, Yuqing , Huang, Lumin et al. FeNC nanozyme-based electrochemical immunoassay for sensitive detection of human epidermal growth factor receptor 2 [J]. | MICROCHIMICA ACTA , 2023 , 190 (10) . |
| MLA | Qiu, Minghao et al. "FeNC nanozyme-based electrochemical immunoassay for sensitive detection of human epidermal growth factor receptor 2" . | MICROCHIMICA ACTA 190 . 10 (2023) . |
| APA | Qiu, Minghao , Ren, Yuqing , Huang, Lumin , Zhu, Xueying , Liang, Tikai , Li, Meijin et al. FeNC nanozyme-based electrochemical immunoassay for sensitive detection of human epidermal growth factor receptor 2 . | MICROCHIMICA ACTA , 2023 , 190 (10) . |
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This work designed a liposome-mediated photocurrent polarity switching immunosensor depending on the reversed photocurrent of iodine-doped BiOCl (I-BOC) nanoflowers induced by the released methylene blue (MB) for the detection of prostate-specific antigen (PSA). Initially, MB-loaded liposomes as indicators were confined within the microplates to participate in the sandwiched immunoreaction and lysed under the treatment of Triton X-100 to release numerous MB. Owing to the host-guest recognition between beta-cyclodextrin (beta-CD) and MB, the released MB was immobilized on the beta-CD-modified I-BOC/FTO electrode and triggered the photocurrent polarity reversal from cathodic photocurrent to anodic photocurrent. The sensing platform realized an accurate and sensitive assay of PSA due to the effective elimination of false-positive/negative signals in a linear range of 0.02-50 ng mL-1 with a limit of detection of 12 pg mL-1. Furthermore, this work not only conjugated liposomeassisted signal amplification strategy with the photocurrent polarity switching system but also provided a novel pathway for various protein determinations.
Keyword ：
Iodine-doped BiOCl nanoflowers Iodine-doped BiOCl nanoflowers Low-abundance protein Low-abundance protein Methylene blue-loaded liposome Methylene blue-loaded liposome Photocurrent-polarity switching Photocurrent-polarity switching Photoelectrochemical immunoassay Photoelectrochemical immunoassay
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| GB/T 7714 | Lin, Qianyun , Lu, Liling , Huang, Xue et al. Photocurrent-polarity switching between methylene blue-loaded liposome and iodine-doped BiOCl for in-situ amplified immunoassay [J]. | TALANTA , 2023 , 268 . |
| MLA | Lin, Qianyun et al. "Photocurrent-polarity switching between methylene blue-loaded liposome and iodine-doped BiOCl for in-situ amplified immunoassay" . | TALANTA 268 (2023) . |
| APA | Lin, Qianyun , Lu, Liling , Huang, Xue , Li, Meijin , Tang, Dianping . Photocurrent-polarity switching between methylene blue-loaded liposome and iodine-doped BiOCl for in-situ amplified immunoassay . | TALANTA , 2023 , 268 . |
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Designing new biochemical sensors and achieving selectivity and high-sensitivity analysis is one of main research directions for immunoassays. Herein, a liposome-amplification photoelectrochemical (PEC) immunoassay was developed using ultrathin mesoporous bismuth chloride oxide nanosheets (BiOCl MSCN) for the highly selective and sensitive detection of carcinoembryonic antigen (CEA). Based on good photocurrent response of BiOCl MSCN toward dopamine, a liposome-conjugated secondary antibody loaded with dopamine was added for specific recognition in the presence of CEA. After the lysis treatment, the liberated dopamine was injected into the three-electrode electrolytic cell to enhance the photocurrent of BiOCl MSCN. Under the optimized conditions, the constructed liposome-mediated PEC immunoassay showed high sensitivity against CEA, with a dynamic response in the linear range of 0.05 ng mL(-1) to 100 ng mL(-1) and a detection limit of 35 pg mL(-1). The present study proposes a new approach to the liposome-mediated PEC immunoassay constructed on ultrathin mesoporous BiOCl nanosheets, which can be used to target further the study of the sensing mechanism.
Keyword ：
Carcinoembryonic antigen Carcinoembryonic antigen Photoelectrochemical immunoassay Photoelectrochemical immunoassay Signal amplification Signal amplification Ultrathin mesoporous BiOCI nanosheets Ultrathin mesoporous BiOCI nanosheets
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| GB/T 7714 | Wang, Haiyang , Wan, Xinyu , Wang, Xin et al. Ultrathin mesoporous BiOCl nanosheets-mediated liposomes for photoelectrochemical immunoassay with in-situ signal amplification [J]. | BIOSENSORS & BIOELECTRONICS , 2023 , 239 . |
| MLA | Wang, Haiyang et al. "Ultrathin mesoporous BiOCl nanosheets-mediated liposomes for photoelectrochemical immunoassay with in-situ signal amplification" . | BIOSENSORS & BIOELECTRONICS 239 (2023) . |
| APA | Wang, Haiyang , Wan, Xinyu , Wang, Xin , Li, Meijin , Tang, Dianping . Ultrathin mesoporous BiOCl nanosheets-mediated liposomes for photoelectrochemical immunoassay with in-situ signal amplification . | BIOSENSORS & BIOELECTRONICS , 2023 , 239 . |
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Hydrogen sulfide (H2S) is an important sulfur-containing signaling molecule in the human body, as well as a highly toxic gas that is soluble in water. A variety of pathological processes are associated with abnormal metabolism of hydrogen sulfide, so it is very important to develop an assay that can rapidly and specifically detect H2S. In this work, two iridium(III) complexes were designed and synthesized using ester groups as reaction sites for recognition of H2S. As the H2S concentration increased, the photoluminescence of the probe was rapidly quenched within 5 s, with a detection limit as low as 0.45 mu M. Among them, the probe Ir1, whose luminescence was located in the visible region, had been successfully used for the detection of trace amounts of H2S in water samples with a recovery rate of 92.5 similar to 104.0% and a relative standard deviation (RSD, n = 5) of < 2.8%. The luminescence of probe Ir2 was located in the near-infrared region, which could avoid the interference of biological autofluorescence and be successfully used for luminescence imaging of H2S in HeLa cells. This study provided a promising method for rapid detection of trace H2S in water samples and cellular microenvironments.
Keyword ：
H2S H2S Iridium(III) complexes Iridium(III) complexes Luminescence imaging Luminescence imaging Photoluminescence Photoluminescence Sensing Sensing
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| GB/T 7714 | Mu, Xiangjun , Zhang, Wanqing , Li, Mei-Jin et al. Design and synthesis of two iridium(III) complex probes for rapid sensing of hydrogen sulfide [J]. | SENSORS AND ACTUATORS B-CHEMICAL , 2023 , 401 . |
| MLA | Mu, Xiangjun et al. "Design and synthesis of two iridium(III) complex probes for rapid sensing of hydrogen sulfide" . | SENSORS AND ACTUATORS B-CHEMICAL 401 (2023) . |
| APA | Mu, Xiangjun , Zhang, Wanqing , Li, Mei-Jin , Fu, Fengfu . Design and synthesis of two iridium(III) complex probes for rapid sensing of hydrogen sulfide . | SENSORS AND ACTUATORS B-CHEMICAL , 2023 , 401 . |
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Glutathione (GSH), homocysteine (Hcy) and cysteine (Cys) play important roles in many physiological processes. However, due to their structural and functional similarities, it is still a challenge to develop a probe that can differentiate between GSH and Hcy/Cys simultaneously. In this work, a luminescent probe Ir-NBD was designed and synthesized, which emit weakly due to the presence of photo induced electron transfer (PET) interaction. When it reacted with the three biothiols, NBD dissociated and luminescence of Ir-OH was enhanced in the nearinfrared (NIR) region due to the disappearance of the PET effect. On the other hand, the products obtained from the reaction of GSH with NBD were hardly luminescent, but the products from the reaction of Hcy/Cys with NBD could undergo an intramolecular rearrangement, resulting in an enhanced luminescence of the solution in the visible region. Ir-NBD enabled highly selective and sensitive detection of GSH and Cys/Hcy in a relatively short time (15 min). The two luminescent colors were clearly differentiated without spectral interference and the detection limit reached 1.32 mu M (GSH), 0.42 mu M (Hcy) and 0.51 mu M (Cys), respectively. Ir-NBD also had low cytotoxicity, it realized the simultaneous detection of GSH and Hcy/Cys by dual-channel luminescence, and also provided ideas for the design of multifunctional luminescent probes.
Keyword ：
Biothiols Biothiols Imaging Imaging Ir(III) complex Ir(III) complex Luminescence Luminescence
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| GB/T 7714 | Mu, Xiangjun , Li, Mei-Jin , Fu, Fengfu . Dual-channel luminescent Ir(III) complex for detection of GSH and Hcy/Cys in cells [J]. | BIOSENSORS & BIOELECTRONICS , 2023 , 246 . |
| MLA | Mu, Xiangjun et al. "Dual-channel luminescent Ir(III) complex for detection of GSH and Hcy/Cys in cells" . | BIOSENSORS & BIOELECTRONICS 246 (2023) . |
| APA | Mu, Xiangjun , Li, Mei-Jin , Fu, Fengfu . Dual-channel luminescent Ir(III) complex for detection of GSH and Hcy/Cys in cells . | BIOSENSORS & BIOELECTRONICS , 2023 , 246 . |
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