A　highly　efficient　and　sensitive　non-enzymatic　glucose　sensor　fabricated　using　NiO/NiPc　composite　nanomaterials　was　introduced　by　this　study.　The　sensor　employed　a　unique　design　by　modifying　the　ITO　electrode　with　the　NiO/NiPc　heterojunction.　This　enhancement　was　achieved　by　improving　charge　separation　and　transfer　through　the　type-II　heterojunction　formed　between　NiO　and　NiPc.　The　integration　of　NiO/NiPc　composite　materials　also　improved　the　electrocatalytic　activity.　This　enhancement　was　attributed　to　the　increased　concentration　of　oxygen　vacancies,　thereby　boosting　the　overall　performance　of　the　sensor.　The　results　of　the　sensor　application　demonstrated　that　under　the　optimized　conditions　(pH　4.0,　-0.3　V　bias),　the　sensor　exhibited　remarkable　sensitivity　and　selectivity　towards　glucose,　with　a　linear　relationship　between　the　photocurrent　change　and　glucose　concentration.　The　detection　limit　was　as　low　as　0.016　nM,　and　the　sensitivity　was　4.146　mu　A　&　sdot;mM-　1　&　sdot;cm-　2.　The　sensor　demonstrated　excellent　repeatability,　stability,　and　high　recovery　rate　in　real　sweat　sample　testing,　highlighting　its　great　potential　for　practical　glucose　detection　applications.