Flexible　piezoresistive-sensing　materials　with　high　sensitivity　and　stable　sensing　signals　are　highly　required　to　meet　the　accurate　detecting　requirement　for　human　motion.　Herein,　a　conductive　poly(3,4-ethylenedioxythiophene):　poly(styrenesulfonate)　/　polydimethylsiloxane　foam　(P:P@p-PSF)　composite　with　strong　interfacial　action　is　designed.　The　porous　structures　and　good　interface　combination　not　only　show　outstanding　mechanical　flexibility　and　reliability　but　also　possess　high　sensitivity　at　a　relatively　wide　strain　range.　The　P:P@p-PSF　sensor　achieves　extreme　sensitivity　(Gauge　Factor)　of　6.25　in　the　subtle　strain　range　of　1%-8%.　Furthermore,　the　sensor　forms　a　highly　interconnected　conductive　network　induced　by　the　serious　deformation　of　elastic-interconnect　pores,　thus　providing　extremely　sensitive　sensing　behavior　for　a　relatively　wide　strain　range　(97.4%　resistance　change　rate　at　60%　compressive　strain).　Moreover,　the　sensor　presents　repeatable　stability　and　good　thermal　adaptation,　which　would　meet　the　critical　requirements　of　subtle　vital　signs,　human　motion　monitoring,　and　so　on.　This　work　supplies　insight　into　the　design　of　a　new　flexible　sensor　material　to　overcome　the　weak　interface　problem　and　the　flexible　mismatch　between　conductive　filler　and　matrix,　showing　great　application　potential　in　the　field　of　electronic　skin.　The　surface　of　PDMS　foam　is　activated　by　oxygen　plasma　treatment　technology,　and　then　the　PEDOT:PSS　firmly　coats　the　pore　surface　of　the　foam　via　forming　sulfonic　ester　covalent　bonds　and　hydrogen　bonds.　The　obtained　conductive　foam　composites　by　combining　these　two　flexible　materials　show　excellent　piezoresistivity　with　high　sensitivity　and　good　cyclic　reliability.　image