A　domino　one-pot　synthesis　of　2-(trifluoromethyl)　benzothiazole　via　copper-mediated　three-component　cascade　reaction　starting　from　the　easily　accessible　starting　materials　such　as　o-iodoanilines,　methyl　trifluoropyruvate,　and　elemental　sulfur　is　reported.　The　present　strategy　displayed　a　comprehensive　substrate　scope　and　good　functional　group　tolerance　and　enabled　access　to　a　variety　of　substituted　2-(trifluoromethyl)　benzothiazoles.　A　2-(trifluoromethyl)　benzoselenazole　has　also　been　synthesized　utilizing　this　reaction　methodology.　A　copper-mediated　three-component　cascade　reaction　for　the　synthesis　of　2-trifluoromethyl　benzothiazole　and　benzoselenazole　was　developed.　The　proposed　mechanism　involved　Ullmann-type　cross-coupling　reaction　with　elemental　sulfur　and　intramelucular　C-S　or　C-Se　bond　formation　through　CuI/CuIII　catalytic　cycle.　image