An　efficient　reaction　of　vinyl　azides　with　difluoroacetic　anhydride　or　chlorodifluoroacetic　anhydride　has　been　developed.　It　involved　sequential　difluoroacetylation　of　vinyl　azides,　followed　by　deprotonation,　cyclization,　and　dinitrogen　elimination,　providing　a　convenient　synthesis　of　both　5-difluoromethyl　and　5-chlorodifluoromethyl　isoxazoles　at　yields　up　to　89%.　(C)　2020　Elsevier　Ltd.　All　rights　reserved.