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Abstract:
A domino one–pot synthesis of 2-(trifluoromethyl) benzothiazole via copper–mediated three–component cascade reaction starting from the easily accessible starting materials such as o-iodoanilines, methyl trifluoropyruvate, and elemental sulfur is reported. The present strategy displayed a comprehensive substrate scope and good functional group tolerance and enabled access to a variety of substituted 2-(trifluoromethyl) benzothiazoles. A 2-(trifluoromethyl) benzoselenazole has also been synthesized utilizing this reaction methodology. © 2024 Wiley-VCH GmbH.
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Source :
Chemistry - An Asian Journal
ISSN: 1861-4728
Year: 2024
Issue: 13
Volume: 19
3 . 5 0 0
JCR@2023
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ESI Highly Cited Papers on the List: 0 Unfold All
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30 Days PV: 1
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