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author:

Zhao Jinxiao (Zhao Jinxiao.) [1] | Wei Tonghui (Wei Tonghui.) [2] | Ke Sen (Ke Sen.) [3] | Li Yi (Li Yi.) [4] (Scholars:李毅)

Indexed by:

Scopus SCIE PKU CSCD

Abstract:

Polycyclic indoles are widely found in natural products and pharmaceutical molecules, and have a wide range of applications in the pharmaceutical, pesticide and dye industries. Although considerable development has been made in the synthesis of indole polycycles, it is still of great scientific interest and value to explore more efficient and milder experimental strategies for the synthesis of highly-functionalized polycyclic indoles. Herein, a one-step radical tandem cyclization reaction to synthesize difluoroalkylindoles with quaternary carbon centers by using difluorobromoesters as the fluorine source and 3-alkenyl indoles as the substrates under visible light-catalyzed conditions was developed. The method is easy-to-operate and mild in conditions, with a wide range of substrate adaptability and good yields, providing a green and efficient synthetic route for fluorine-containing polycyclic indoles.

Keyword:

cascade cyclization difluoroalkylation polycyclic indole radical reaction visible light catalysis

Community:

  • [ 1 ] [Zhao Jinxiao]Fuzhou Univ, Coll Chem, Fuzhou 350108, Peoples R China
  • [ 2 ] [Wei Tonghui]Fuzhou Univ, Coll Chem, Fuzhou 350108, Peoples R China
  • [ 3 ] [Ke Sen]Fuzhou Univ, Coll Chem, Fuzhou 350108, Peoples R China
  • [ 4 ] [Li Yi]Fuzhou Univ, Coll Chem, Fuzhou 350108, Peoples R China

Reprint 's Address:

  • [Li Yi]Fuzhou Univ, Coll Chem, Fuzhou 350108, Peoples R China;;

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Source :

CHINESE JOURNAL OF ORGANIC CHEMISTRY

ISSN: 0253-2786

CN: 31-1321/O6

Year: 2023

Issue: 3

Volume: 43

Page: 1102-1114

1 . 8

JCR@2023

1 . 8 0 0

JCR@2023

ESI Discipline: CHEMISTRY;

ESI HC Threshold:39

JCR Journal Grade:3

CAS Journal Grade:4

Cited Count:

WoS CC Cited Count: 0

SCOPUS Cited Count: 2

ESI Highly Cited Papers on the List: 0 Unfold All

WanFang Cited Count:

Chinese Cited Count:

30 Days PV: 2

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