Preparing　sponge　dressings　with　stable　wet　adhesion　remains　difficult　in　wound　repair,　especially　in　burn　wounds　with　bleeding　and　large　amounts　of　exudate.　In　this　work,　a　multifunctional　hybrid　sponge　dressing　(DHGT+PHMB+TiO2NPs)　with　good　wet　adhesion　was　developed　by　combining　biomimetic　and　enzymatic　cross-linking　reactions.　The　sponge　dressing　matrix　(DHGT)　was　prepared　by　tyrosinase-catalyzed　cross-linking　of　dopamine-modified　hyaluronic　acid　(DOPA-HA)　and　gelatin.　The　multifunctional　hybrid　sponge　dressing　was　obtained　by　loading　polyhexamethylene　biguanide　(PHMB)　and　titanium　dioxide　nanoparticles　(TiO2NPs)　onto　the　DHGT　matrix.　The　newly　developed　sponge　dressing　exhibited　high　mechanical　properties,　good　wet　adhesion,　antibacterial　activity,　reactive　oxygen　species　(ROS)　scavenging,　biocompatibility,　and　excellent　hemostasis　ability.　In　vivo　studies　showed　that　the　multifunctional　hybrid　sponge　dressing　could　significantly　accelerate　the　healing　of　infected　full-thickness　burn　wounds　by　inhibiting　bacterial　growth,　accelerating　skin　tissue　reepithelialization,　collagen　deposition,　and　angiogenesis,　as　well　as　regulating　the　expression　of　inflammatory　factors　and　cytokines.　©　2022　Elsevier　B.V.