With　a　view　to　developing　highly　efficient　photosensitizers　for　both　antitumor　and　antimicrobial　photodynamic　therapies,　herein,　we　reported　a　super　cationic　zinc(II)　phthalocyanine　(Pc4),　which　was　prepared　through　the　quaternization　of　the　N,　N-dimethyl-3-aminophenoxyl-hexadeca-substituted　precursor　Pc3.　Meanwhile,　two　disubstituted　analogues　(Pc1　and　Pc2)　were　also　prepared　as　controls.　The　cationic　Pc2　and　Pc4　had　higher　photoactivities　including　fluorescence　and　singlet　oxygen　than　the　neutral　counterparts　Pc1.　and　Pc3,　probably　because　of　the　inhibition　of　intramolecular　charge　transfer　(ICT)　effect　of　the　amino　groups.　With　the　bulky　steric　effect　and　high　hydmphilicity,　Pc4　presented　non-aggregated　behavior　in　aqueous　solutions.　Therefore,　it　exhibited　the　highest　in　vitro　photodynamic　activity　toward　HepG2　cancer　cells　with　an　IC50　value　as　low　as　0.04　mu　M.　Furthermore,　Pc4　showed　a　highly　efficient　in　vivo　PDT　effect　on　H22　tumor-bearing　mice　with　98.7%　tumor　growth　inhibition.　In　addition,　Pc4　also　exhibited　an　excellent　in　vitro　and　in　vivo　photodynamic　inactivation　against　S.　aureus.　The　results　indicate　that　the　non-aggregated　hexadeca-cationic　Pc4　could　serve　as　a　promising　photosensitizer　for　both　antitumor　and　antimicrobial　photodynamic　therapies.