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Abstract：
Phoma fungi are known to produce a diverse range of natural products which possess various biological activities such as antifungal, antimicrobial, insecticidal, cytotoxic, and immunomodulatory effects. In our present study, we have isolated two novel polyketides (1 and 3), one new sesquiterpenoid (2), and eight known compounds (4-11) from the culture of Phoma sp. 3A00413, a deep-sea sulphide-derived fungus. The structures of compounds 1-3 were elucidated using NMR, MS, NMR calculation, and ECD calculation. In vitro antibacterial activities of all the isolated compounds were evaluated against Escherichia coli, Vibrio parahaemolyticus vp-HL, Vibrio para-haemolyticus, Staphylococcus aureus, Vibrio vulnificus, and Salmonella enteritidis. Compounds 1, 7, and 8 exhibited weak inhibition against Staphylococcus aureus growth, while compounds 3 and 7 showed weak inhibition against Vibrio vulnificus growth. Importantly, compound 3 demonstrated exceptional potency against Vibrio para-haemolyticus, with a minimum inhibitory concentration (MIC) of 3.1 & mu;M.
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FITOTERAPIA
ISSN： 0367-326X
Year： 2023
Volume： 168
3 . 4 0 0
JCR@2022
ESI Discipline： PHARMACOLOGY & TOXICOLOGY;
ESI HC Threshold：14
CAS Journal Grade：3
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ESI Highly Cited Papers on the List： 0 Unfold All
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30 Days PV： 2
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