Quaternary　ammonium　compounds　(QACs)　are　inexpensive　and　readily　available　disinfectants,　and　have　been　widely　used,　especially　since　the　COVID-19　outbreak.　The　toxicity　of　QACs　to　humans　has　raised　increasing　concerns　in　recent　years.　Here,　a　new　type　of　QACs　was　synthesized　by　replacing　the　alkyl　chain　with　zinc　phthalocyanine　(ZnPc),　which　consists　of　a　large　aromatic　ring　and　is　hydrophobic　in　nature,　similar　to　the　alkyl　chain　of　QACs.　Three　ZnPc-containing　disinfectants　were　synthesized　and　fully　characterized.　These　compounds　showed　15–16　fold　higher　antimicrobial　effect　against　Gram-negative　bacteria　than　the　well-known　QACs　with　half-maximal　inhibitory　(IC50)　values　of　1.43　μM,　2.70　μM,　and　1.31　μM,　respectively.　With　the　assistance　of　680　nm　light,　compounds　4　and　6　had　much　higher　bactericidal　toxicities　at　nanomolar　concentrations.　Compound　6　had　a　bactericidal　efficacy　of　close　to　6　logs　(99.9999%　kill　rate)　at　1　μM　to　Gram-positive　bacteria,　including　MRSA,　under　light　illumination.　Besides,　these　compounds　were　safe　for　mammalian　cells.　In　a　mouse　model,　compound　6　was　effective　in　healing　wound　infection.　Importantly,　compound　6　was　easily　degraded　at　working　concentrations　under　sunlight　illumination,　and　is　environmentally　friendly.　Thus,　compound　6　is　a　novel　and　promising　disinfectant.　©　2022