Thermoplastic　polyurethane　(TPU)　has　been　extensively　used　in　many　industrial　fields　because　of　its　excellent　mechanical,　electrically　insulating　and　chemical/oil-resistant　properties.　However,　it　is　inherently　flammable　and　produces　a　huge　amount　of　heat　and　smoke　upon　ignition,　significantly　impeding　its　industrial　applications.　Current　fire-retardant　strategies　often　result　in　significantly　reduced　flam-mability,　but　limited　contribution　to　smoke　suppression,　and　even　reduced　mechanical　properties　due　to　different　governing　mechanisms.　To　overcome　this　hurdle,　herein,　we　reported　a　titanium　carbide-derived　nanohybrid　(Ti3C2Tx-D-H)　via　simple　hydrogen-bonding　assembly.　Our　results　show　that　the　peak　of　heat　release　rate　and　total　smoke　release　yield　of　TPU　nanocomposite　containing　2.0　wt%　Ti3C2Tx-D-H　are　decreased　by　27.3%　and　43.8%,　respectively,　compared　to　those　of　pure　TPU.　Besides,　the　resultant　TPU　nanocomposite　shows　32.8%　and　56.8%　increases　in　tensile　strength　and　toughness,　respectively.　The　distinguished　fire-resistance　and　mechanical　performances　are　ascribed　to　the　tortuous　effect,　catalyzed　charring　and　free　radicals　quenching　function　of　Ti3C2Tx-D-H　nanohybrid　together　with　a　favorable　TPU-Ti3C2Tx-D-H　interface.　This　work　offers　a　promising　strategy　for　simultaneously　enhancing　the　fire　resistance,　smoke　suppression　and　mechanical　robustness　of　TPU,　which　is　expected　to　find　more　in-dustrial　applications.　(C)　2022　Elsevier　Ltd.　All　rights　reserved.