Thermoplastic　polyurethane　(TPU)　has　been　extensively　used　in　many　industrial　fields　because　of　its　excellent　mechanical,　electrically　insulating　and　chemical/oil-resistant　properties.　However,　it　is　inherently　flammable　and　produces　a　huge　amount　of　heat　and　smoke　upon　ignition,　significantly　impeding　its　industrial　applications.　Current　fire-retardant　strategies　often　result　in　significantly　reduced　flammability,　but　limited　contribution　to　smoke　suppression,　and　even　reduced　mechanical　properties　due　to　different　governing　mechanisms.　To　overcome　this　hurdle,　herein,　we　reported　a　titanium　carbide-derived　nanohybrid　(Ti3C2Tx-D-H)　via　simple　hydrogen-bonding　assembly.　Our　results　show　that　the　peak　of　heat　release　rate　and　total　smoke　release　yield　of　TPU　nanocomposite　containing　2.0　wt%　Ti3C2Tx-D-H　are　decreased　by　27.3%　and　43.8%,　respectively,　compared　to　those　of　pure　TPU.　Besides,　the　resultant　TPU　nanocomposite　shows　32.8%　and　56.8%　increases　in　tensile　strength　and　toughness,　respectively.　The　distinguished　fire-resistance　and　mechanical　performances　are　ascribed　to　the　tortuous　effect,　catalyzed　charring　and　free　radicals　quenching　function　of　Ti3C2Tx-D-H　nanohybrid　together　with　a　favorable　TPU-Ti3C2Tx-D-H　interface.　This　work　offers　a　promising　strategy　for　simultaneously　enhancing　the　fire　resistance,　smoke　suppression　and　mechanical　robustness　of　TPU,　which　is　expected　to　find　more　industrial　applications.　©　2022　Elsevier　Ltd