Human　lymphocytes　as　well　as　zebrafish　embryos　were　used　to　study　the　toxicity　of　acrylamide,　and　the　intervention　effects　of　the　dietary　antioxidants　(-)-epigallocatechin　gallate　and　curcumin　have　been　examined.　The　alkaline　comet　assay　revealed　that　acrylamide　(1,　5,　10　mmol/L)　had　dose-response　effects　on　basic　DNA　damage　and　oxidative　DNA　damage　in　human　lymphocytes.　Exposure　of　zebrafish　embryos　to　acrylamide　resulted　in　decrease　of　hatching　rate,　and　in　increases　of　mortality　and　teratogenicity.　(-)-Epigallocatechin　gallate　and　curcumin　reduced　DNA　damage　and　protected　zebrafish　embryos　in　the　growth　and　development.