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Abstract ：
Drug repurposing uses approved drugs as candidate anticancer therapeutics, harnesses previous research and development efforts, and benefits from available clinically suitable formulations and evidence of patient tolerability. In this work, the drug used clinically to treat chronic alcoholism, disulfiram (DSF), was studied for its antitumor efficacy in a copper-dependent manner. The combination of DSF and copper could achieve a tumor cell growth inhibition effect comparable to those of 5-fluorouracil and taxol on head and neck cancer cells. Both bulk dendrimer hydrogel and microsized dendrimer hydrogel particles were utilized for the localized sustained release of copper in the tumor site. The localized sustained release of copper facilitated the tumor inhibition effect following intratumoral injection in a mouse's head and neck cancer model.
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| GB/T 7714 | Wang, Juan , Li, Boxuan , Cooper, Remy C. et al. Localized Sustained Release of Copper Enhances Antitumor Effects of Disulfiram in Head and Neck Cancer [J]. | BIOMACROMOLECULES , 2024 , 25 (5) : 2770-2779 . |
| MLA | Wang, Juan et al. "Localized Sustained Release of Copper Enhances Antitumor Effects of Disulfiram in Head and Neck Cancer" . | BIOMACROMOLECULES 25 . 5 (2024) : 2770-2779 . |
| APA | Wang, Juan , Li, Boxuan , Cooper, Remy C. , Huang, Da , Yang, Hu . Localized Sustained Release of Copper Enhances Antitumor Effects of Disulfiram in Head and Neck Cancer . | BIOMACROMOLECULES , 2024 , 25 (5) , 2770-2779 . |
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The prescription of a course of oral antibiotics following bone grafting procedures is a common practice in clinical periodontics to reduce surgical site infections. The goal of this study is to characterize the release profile of antibiotics via local delivery using dendrimer hydrogels (DH) and to analyze the effect of two different particulate bone allografts on the release of the antibiotics in vitro. DH were synthesized from polyamidoamine (PAMAM) dendrimer G5 and polyethylene glycol diacrylate, and cefazolin was chosen as the antibiotic. The antibiotic-loaded samples were bathed in PBS and incubated at 37 degrees C; aliquots were taken (1 h, 2 h, 3 h, 4 h, 5 h, 6 h, 12 h, 24 h, 48 h, 72 h) and analyzed using HPLC to determine the amounts of released cefazolin. In samples with DH, the estimated maximum concentration of cefazolin was 36.97 +/- 2.39 mu g/mL (95% CI: 34.58-39.36) with 50% released in 4.17 h (95%: 3.26-5.07) and an estimated growth rate of 0.27 (95% CI: 0.17-0.37). For samples without DH, the estimated maximum concentration of cefazolin was 167.4 +/- 7.0 mu g/mL (95% CI: 160.4-174.4) with 50% released in 2.36 h (95% CI: 2.05-2.67) and an estimated growth rate of 0.70 (95% CI: 0.54-0.87). We conclude that DH are a promising platform for sustained antibiotic release and that the presence of bone grafts did not significantly affect their release.
Keyword ：
antibiotic antibiotic cefazolin cefazolin hydrogel hydrogel local delivery local delivery PAMAM dendrimer PAMAM dendrimer
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| GB/T 7714 | Yesbeck, Nicholas , Huang, Da , Carrico, Caroline et al. Antibiotic-Loaded Dendrimer Hydrogels in Periodontal Bone Regeneration: An In Vitro Release Feasibility Study [J]. | GELS , 2024 , 10 (9) . |
| MLA | Yesbeck, Nicholas et al. "Antibiotic-Loaded Dendrimer Hydrogels in Periodontal Bone Regeneration: An In Vitro Release Feasibility Study" . | GELS 10 . 9 (2024) . |
| APA | Yesbeck, Nicholas , Huang, Da , Carrico, Caroline , Madurantakam, Parthasarathy , Yang, Hu . Antibiotic-Loaded Dendrimer Hydrogels in Periodontal Bone Regeneration: An In Vitro Release Feasibility Study . | GELS , 2024 , 10 (9) . |
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Laminectomy is a commonly performed surgical procedure by orthopedic and neurosurgeons, aimed at alleviating nerve compression and reducing pain. However, in some cases, excessive proliferation of fibrous scar tissue in the epidural space post-surgery can lead to persistent and intractable lower back pain, a condition known as Failed Back Surgery Syndrome (FBSS). The persistent fibrous tissue causes both physical and emotional distress for patients and also makes follow-up surgeries more challenging due to reduced visibility and greater technical difficulty. It has been established that the application of biomaterials to prevent epidural fibrosis post-lumbar surgery is more beneficial than revision surgeries to relieve dural fibrosis. Hydrogel-based biomaterials, with their excellent biocompatibility, degradability, and injectability and tunable mechanical properties, have been increasingly introduced by clinicians and researchers. This paper, building on the foundation of epidural fibrosis, primarily discusses the strategies for the preparation of natural and polymeric biomaterials to prevent epidural fibrosis, their physicochemical properties, and their ability to mitigate the excessive proliferation of fibroblasts. It also emphasizes the challenges that need to be addressed to translate laboratory research into clinical practice and the latest advancements in this field.
Keyword ：
anti-adhesion anti-adhesion biomaterials biomaterials dural mater dural mater low back pain low back pain tissue engineering tissue engineering
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| GB/T 7714 | Yan, Taoxu , Cheng, Junyao , He, Qing et al. Polymeric Dural Biomaterials in Spinal Surgery: A Review [J]. | GELS , 2024 , 10 (9) . |
| MLA | Yan, Taoxu et al. "Polymeric Dural Biomaterials in Spinal Surgery: A Review" . | GELS 10 . 9 (2024) . |
| APA | Yan, Taoxu , Cheng, Junyao , He, Qing , Wang, Yifan , Zhang, Chuyue , Huang, Da et al. Polymeric Dural Biomaterials in Spinal Surgery: A Review . | GELS , 2024 , 10 (9) . |
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Efficient topical drug delivery remains a significant challenge in glaucoma management. Although nanoparticle formulations offer considerable promise, their complex preparation processes, co-delivery issues, and batch consistency have hindered their potential. A scalable fabrication strategy is developed here for preparing solid drug nanoparticles (SDNs) with enhanced drug delivery efficiency. Utilizing hydrophobic antiglaucoma drugs brimonidine (BM) and betaxolol (BX), uniform fixed combination BM/BX SDNs are fabricated through a continuous process, improving batch-to-batch consistency for combined glaucoma treatment. With trehalose being used as a lyoprotectant, BM/BX SDNs can be stored as dry powder and easily reconstituted in phosphate buffered saline. Importantly, reconstituted BM/BX SDNs form clear, homogenous solutions, and exhibit negligible cytotoxicity and irritation, making them well-suited for topical administration as eyedrops. Ex vivo and in vivo studies demonstrated that topically applied BM/BX SDNs permeate through the cornea significantly (about two fold to three fold) compared to their hydrophilic counterparts, i.e., brimonidine tartrate, and betaxolol hydrogen chloride. Notably, BM/BX SDNs displayed consistent intraocular pressure lowering effects in vivo in both normotensive rats and glaucoma mice. Collectively, this study demonstrates the potential of the scalable fabrication strategy and the resultant BM/BX SDNs for improving glaucoma management through eyedrops. Using a scalable method for fabricating solid drug nanoparticles (SDNs), SDNs in fixed combination of the hydrophobic antiglaucoma drugs brimonidine (BM) and betaxolol (BX) are consistently produced. These SDNs demonstrated enhanced ocular permeation and sustained intraocular pressure reduction, indicating their effectiveness for glaucoma therapy. image
Keyword ：
anti-glaucoma drugs anti-glaucoma drugs cornea permeation cornea permeation ocular hypertension ocular hypertension scalable fabrication scalable fabrication solid drug nanoparticles solid drug nanoparticles
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| GB/T 7714 | Huang, Da , Norat, Pedro , Qi, Lin et al. Consistent Intraocular Pressure Reduction by Solid Drug Nanoparticles in Fixed Combinations for Glaucoma Therapy [J]. | ADVANCED SCIENCE , 2024 . |
| MLA | Huang, Da et al. "Consistent Intraocular Pressure Reduction by Solid Drug Nanoparticles in Fixed Combinations for Glaucoma Therapy" . | ADVANCED SCIENCE (2024) . |
| APA | Huang, Da , Norat, Pedro , Qi, Lin , Chernatynskaya, Anna , Cole, James D. , Mani, Vimalin Jeyalatha et al. Consistent Intraocular Pressure Reduction by Solid Drug Nanoparticles in Fixed Combinations for Glaucoma Therapy . | ADVANCED SCIENCE , 2024 . |
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Intervertebral disc degeneration (IVDD) stands as the foremost contributor to low back pain (LBP), imposing a substantial weight on the world economy. Traditional treatment modalities encompass both conservative approaches and surgical interventions; however, the former falls short in halting IVDD progression, while the latter carries inherent risks. Hence, the quest for an efficacious method to reverse IVDD onset is paramount. Biomaterial delivery systems, exemplified by hydrogels, microspheres, and microneedles, renowned for their exceptional biocompatibility, biodegradability, biological efficacy, and mechanical attributes, have found widespread application in bone, cartilage, and various tissue engineering endeavors. Consequently, IVD tissue engineering has emerged as a burgeoning field of interest. This paper succinctly introduces the intervertebral disc (IVD) structure and the pathophysiology of IVDD, meticulously classifies biomaterials for IVD repair, and reviews recent advances in the field. Particularly, the strengths and weaknesses of biomaterials in IVD tissue engineering are emphasized, and potential avenues for future research are suggested.
Keyword ：
biomaterials biomaterials intervertebral disc intervertebral disc intervertebral disc degeneration intervertebral disc degeneration tissue engineering tissue engineering
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| GB/T 7714 | Wang, Yifan , Zhang, Chuyue , Cheng, Junyao et al. Cutting-Edge Biomaterials in Intervertebral Disc Degeneration Tissue Engineering [J]. | PHARMACEUTICS , 2024 , 16 (8) . |
| MLA | Wang, Yifan et al. "Cutting-Edge Biomaterials in Intervertebral Disc Degeneration Tissue Engineering" . | PHARMACEUTICS 16 . 8 (2024) . |
| APA | Wang, Yifan , Zhang, Chuyue , Cheng, Junyao , Yan, Taoxu , He, Qing , Huang, Da et al. Cutting-Edge Biomaterials in Intervertebral Disc Degeneration Tissue Engineering . | PHARMACEUTICS , 2024 , 16 (8) . |
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Hydrogel dressings capable of infection monitoring and precise treatment administration show promise for advanced wound care. Existing methods involve embedd ingorganic dyes or flexible electronics into preformed hydrogels, which raise safety issues and adaptability challenges. In this study, an injectable hydrogel based smart wound dressing is developed by integrating food-derived anthocyanidin as a visual pH probe for infection monitoring and poly(L-lactic acid) microcapsules as ultrasound-responsive delivery systems for antibiotics into a poly(ethylene glycol) hydrogel. This straightforwardly prepared hydrogel dressing maintains its favorable properties for wound repair, including porous morphology and excellent biocompatibility. In vitro experiments demonstrated that the hydrogel enabled visual assessment of pH within the range of 5 similar to 9.Meanwhile, the release of antibiotics could be triggered and controlled by ultrasound. In vivo evaluations using infected wounds and diabetic wounds revealed that the wound dressing effectively detected wound infection by monitoring pH levels and achieved antibacterial effects through ultrasound-triggered drug release. This led to significantly enhanced wound healing, as validated by histological analysis and the measurement of inflammatory cytokine levels. This injectable hydrogel-based smart wound dressing holds great potential for use in clinical settings to inform timely and precise clinical intervention and in community to improve wound care management. The study presents an injectable hydrogel dressing with flexibility to fit irregularly shaped wounds and excellent biocompatibility for visual monitoring of infection and on-demand treatment. It utilizes food-derived anthocyanidin as a pH probe and poly(L-lactic acid) microcapsules for ultrasound-responsive drug delivery. In diabetic wounds, the dressing detects infections through pH monitoring and enhances healing via ultrasound-triggered drug release.image
Keyword ：
chronic wounds chronic wounds hydrogels hydrogels on-demand treatment on-demand treatment pH detection pH detection ultrasound responsive ultrasound responsive wound monitoring wound monitoring
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| GB/T 7714 | Huang, Da , Du, Jiahao , Luo, Fang et al. Injectable Hydrogels with Integrated Ph Probes and Ultrasound-Responsive Microcapsules as Smart Wound Dressings for Visual Monitoring and On-Demand Treatment of Chronic Wounds [J]. | ADVANCED HEALTHCARE MATERIALS , 2024 , 13 (9) . |
| MLA | Huang, Da et al. "Injectable Hydrogels with Integrated Ph Probes and Ultrasound-Responsive Microcapsules as Smart Wound Dressings for Visual Monitoring and On-Demand Treatment of Chronic Wounds" . | ADVANCED HEALTHCARE MATERIALS 13 . 9 (2024) . |
| APA | Huang, Da , Du, Jiahao , Luo, Fang , He, Gang , Zou, Minglang , Wang, Yongming et al. Injectable Hydrogels with Integrated Ph Probes and Ultrasound-Responsive Microcapsules as Smart Wound Dressings for Visual Monitoring and On-Demand Treatment of Chronic Wounds . | ADVANCED HEALTHCARE MATERIALS , 2024 , 13 (9) . |
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Curcumin (CUR) is a natural polyphenol that holds promise for treating ulcerative colitis (UC), yet oral administration of CUR exhibits limited bioavailability and existing formulations for oral delivery of CUR often suffer from unsatisfactory loading capacity. This study presents hydroxyethyl starch-curcumin microspheres (HCMSs) with excellent CUR loading capacity (54.52 %), and the HC-MSs can further encapsulate anti-inflammatory drugs dexamethasone (DEX) to obtain a combination formulation (DHC-MSs) with high DEX loading capacity (19.91 %), for combination therapy of UC. The microspheres were successfully engineered, retaining the antioxidative and anti-inflammatory activities of parental CUR and demonstrating excellent biocompatibility and controlled release properties, notably triggered by alpha-amylase, facilitating targeted drug delivery to inflamed sites. In a mouse UC model induced by dextran sulfate sodium, the microspheres effectively accumulated in inflamed colons and both HC-MSs and DHC-MSs exhibited superior therapeutic efficacy in alleviating UC symptoms compared to free DEX. Moreover, mechanistic exploration uncovered the multifaceted therapeutic mechanisms of these formulations, encompassing anti-inflammatory actions, mitigation of spleen enlargement, and modulation of gut microbiota composition. These findings underscore the potential of HC-MSs and DHC-MSs as promising formulations for UC, with implications for advancing treatment modalities for various inflammatory bowel disorders.
Keyword ：
Anti-inflammatory Anti-inflammatory Curcumin Curcumin Gut microbiota Gut microbiota Microspheres Microspheres Oral delivery Oral delivery Ulcerative colitis Ulcerative colitis
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| GB/T 7714 | Huang, Da , Wang, Yongming , Xu, Chenlan et al. Colon-targeted hydroxyethyl starch-curcumin microspheres with high loading capacity ameliorate ulcerative colitis via alleviating oxidative stress, regulating inflammation, and modulating gut microbiota [J]. | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES , 2024 , 266 . |
| MLA | Huang, Da et al. "Colon-targeted hydroxyethyl starch-curcumin microspheres with high loading capacity ameliorate ulcerative colitis via alleviating oxidative stress, regulating inflammation, and modulating gut microbiota" . | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 266 (2024) . |
| APA | Huang, Da , Wang, Yongming , Xu, Chenlan , Zou, Minglang , Ming, Yangcan , Luo, Fang et al. Colon-targeted hydroxyethyl starch-curcumin microspheres with high loading capacity ameliorate ulcerative colitis via alleviating oxidative stress, regulating inflammation, and modulating gut microbiota . | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES , 2024 , 266 . |
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Shape memory cryogels hold immense promise for non-compressible hemostasis due to their shape recovery after contacting with blood. However, there is still a lack of an easy way to accelerate the shape-recovery speed which is highly associated with its performance. Meanwhile, the incorporation of extra pro-coagulation mechanisms will further improve the hemostatic efficacy. Herein, surfactant-stabilized bubbles are used to improve the shape-recovery speed of cryogels (GHP) through the modulation of porosity and pore size based on the capillary action. Additionally, 2D nanosheet vermiculite (VMT) is fabricated and incorporated into the system to get VMT@GHP cryogels. Remarkably, VMT@GHP exhibits a fast shape recovery speed (1.3 +/- 0.3 s in the blood) among reported hemostats and the ability to promote blood coagulation. Animal studies show that VMT@GHP significantly accelerates the hemostasis in both rat and pig models, even in heparinized situations. In summary, VMT@GHP represents a highly effective solution for non-compressible hemorrhage control, with promising prospects for clinical translation.
Keyword ：
cryogel cryogel hemostasis hemostasis non-compressible hemorrhage non-compressible hemorrhage shape memory shape memory vermiculite vermiculite
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| GB/T 7714 | Wang, Binhui , Zhu, Bin , Liu, Yihao et al. Fast Recoverable Shape Memory Cryogels Engineered with Surfactant-Stabilized Bubbles and Vermiculite for Non-Compressible Hemostasis [J]. | ADVANCED FUNCTIONAL MATERIALS , 2024 , 35 (4) . |
| MLA | Wang, Binhui et al. "Fast Recoverable Shape Memory Cryogels Engineered with Surfactant-Stabilized Bubbles and Vermiculite for Non-Compressible Hemostasis" . | ADVANCED FUNCTIONAL MATERIALS 35 . 4 (2024) . |
| APA | Wang, Binhui , Zhu, Bin , Liu, Yihao , Ren, Bowen , Chen, Yurong , Feng, Luyao et al. Fast Recoverable Shape Memory Cryogels Engineered with Surfactant-Stabilized Bubbles and Vermiculite for Non-Compressible Hemostasis . | ADVANCED FUNCTIONAL MATERIALS , 2024 , 35 (4) . |
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The global crisis of bacterial infections is exacerbated by the escalating threat of microbial antibiotic resistance. Nanozymes promise to provide ingenious solutions. Here, we reported a homogeneous catalytic structure of Pt nanoclusters with finely tuned metal-organic framework (ZIF-8) channel structures for the treatment of infected wounds. Catalytic site normalization showed that the active site of the Pt aggregates structure with fine-tuned pore modifications structure had a catalytic capacity of 14.903x105 min-1, which was 18.7 times higher than that of the Pt particles in monodisperse state in ZIF-8 (0.793x105 min-1). In situ tests revealed that the change from homocleavage to heterocleavage of hydrogen peroxide at the interface of the nanozyme was one of the key reasons for the improvement of nanozyme activity. Density-functional theory and kinetic simulations of the reaction interface jointly determine the role of the catalytic center and the substrate channel together. Metabolomics analysis showed that the developed nanozyme, working in conjunction with reactive oxygen species, could effectively block energy metabolic pathways within bacteria, leading to spontaneous apoptosis and bacterial rupture. This pioneering study elucidates new ideas for the regulation of artificial enzyme activity and provides new perspectives for the development of efficient antibiotic substitutes.
Keyword ：
bacterial energy metabolism pathways bacterial energy metabolism pathways density functional theory density functional theory metal-organic framework metal-organic framework nanozyme nanozyme platinum catalysts platinum catalysts
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| GB/T 7714 | Yu, Zhichao , Xu, Zhenjin , Zeng, Ruijin et al. Tailored Metal-Organic Framework-Based Nanozymes for Enhanced Enzyme-Like Catalysis [J]. | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION , 2024 , 64 (7) . |
| MLA | Yu, Zhichao et al. "Tailored Metal-Organic Framework-Based Nanozymes for Enhanced Enzyme-Like Catalysis" . | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 64 . 7 (2024) . |
| APA | Yu, Zhichao , Xu, Zhenjin , Zeng, Ruijin , Xu, Man , Zou, Minglang , Huang, Da et al. Tailored Metal-Organic Framework-Based Nanozymes for Enhanced Enzyme-Like Catalysis . | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION , 2024 , 64 (7) . |
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A high-efficiency PtZnCd nanozyme was screened with density functional theory (DFT) and unique d-orbital coupling features for sensitive enrichment and real-time analysis of CO-releasing molecule-3 (CORM-3). Multicatalytic sites in the nanozyme showed a high reactivity of up to 72.89 min-1 for peroxidase (POD)-like reaction, which was 2.2, 4.07, and 14.67 times higher than that of PtZn (32.67 min-1), PtCd (17.89 min-1), and Pt (4.97 min-1), respectively. Normalization of the catalytic sites showed that the catalytic capacity of the active site in PtZnCd was 2.962 U mu mol-1, which was four times higher than that of a pure Pt site (0.733 U mu mol-1). DFT calculations showed that improved d-orbital coupling between different metals reduces the position of the center of the shifted whole d-band relative to the Fermi energy level, thereby increasing the contribution of the sites to the electron transfer from the active center, accompanied by enhanced substrate adsorption and intermediate conversion in the catalytic process. The potential adsorption principle and color development mechanism of CORM-3 on PtZnCd were determined, and its practical application in drug metabolism was validated in vitro and in zebrafish and mice models, demonstrating that transition-metal doping effectively engineers high-performance nanozymes and optimizes artificial enzymes.
Keyword ：
nanozymes nanozymes peroxidase-like activity peroxidase-like activity pharmacovigilance pharmacovigilance platinum catalysts platinum catalysts
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| GB/T 7714 | Yu, Zhichao , Xu, Zhenjin , Zeng, Ruijin et al. D-Band-Center-Engineered Platinum-Based Nanozyme for Personalized Pharmacovigilance [J]. | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION , 2024 , 64 (2) . |
| MLA | Yu, Zhichao et al. "D-Band-Center-Engineered Platinum-Based Nanozyme for Personalized Pharmacovigilance" . | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 64 . 2 (2024) . |
| APA | Yu, Zhichao , Xu, Zhenjin , Zeng, Ruijin , Xu, Man , Zheng, Haisu , Huang, Da et al. D-Band-Center-Engineered Platinum-Based Nanozyme for Personalized Pharmacovigilance . | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION , 2024 , 64 (2) . |
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