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学者姓名：黄达
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Abstract ：
The intracellular delivery of protein drugs via nanocarriers offers significant potential for expanding their therapeutic applications. However, the unintended activation of innate immune responses and inflammation triggered by the carriers presents a major challenge, often compromising therapeutic efficacy. Here, we present oligoethylenimine-thioketal (OEI-TK), a reactive oxygen species-responsive cationic polymer with intrinsic anti-inflammatory properties, to overcome this challenge. OEI-TK self-assembles electrostatically with bovine serum albumin (BSA) to form stable nanoparticles (OTB NPs) with excellent encapsulation efficiency. In vitro studies confirmed that OTB NPs retained OEI-TK's antioxidant and anti-inflammatory properties, enhanced biocompatibility, and efficiently delivered BSA into cells. Furthermore, OEI-TK facilitated the intracellular delivery of beta-galactosidase while preserving its enzymatic activity, demonstrating its potential for functional protein transport. These findings highlight OEI-TK as a promising platform with dual benefits of inflammation modulation and intracellular protein delivery, holding potential for the synergistic treatment of inflammation-related diseases.
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| GB/T 7714 | Wang, Yongming , Ming, Yangcan , Yu, Zhichao et al. ROS-Responsive Cationic Polymers with Intrinsic Anti-Inflammatory Activity for Intracellular Protein Delivery [J]. | BIOMACROMOLECULES , 2025 , 26 (4) : 2268-2281 . |
| MLA | Wang, Yongming et al. "ROS-Responsive Cationic Polymers with Intrinsic Anti-Inflammatory Activity for Intracellular Protein Delivery" . | BIOMACROMOLECULES 26 . 4 (2025) : 2268-2281 . |
| APA | Wang, Yongming , Ming, Yangcan , Yu, Zhichao , Xu, Zhenjin , Zou, Minglang , Chen, Cuiping et al. ROS-Responsive Cationic Polymers with Intrinsic Anti-Inflammatory Activity for Intracellular Protein Delivery . | BIOMACROMOLECULES , 2025 , 26 (4) , 2268-2281 . |
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This work reports the development and evaluation of dendrimer-based nanogels based on polyamidoamine (PAMAM) dendrimer generation 5, engineered to act as a carrier with reactive oxygen species (ROS)-scavenging capabilities. We developed a cross-linking reaction-enabled flash nanoprecipitation method in which the cross-linking reaction occurs during the flash nanoprecipitation process to form a cross-linked nanostructure. Using this approach, an N-hydroxysuccinimide (NHS)-functionalized ROS-responsive thioketal cross-linker (TK-NHS) was synthesized and utilized to cross-link DAB-core PAMAM dendrimer G5, resulting in the formation of G5-TK nanogels. The resulting nanogels were characterized using dynamic light scattering and transmission electron microscopy, and their cytocompatibility, irritancy, cellular uptake, and ROS scavenging activity were assessed. We confirmed the ROS scavenging capability of these nanogels and observed favorable safety profiles. The G5-TK nanogels can be further developed as carriers for therapeutic delivery applications to treat oxidative stress-related pathological conditions.
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| GB/T 7714 | Qi, Lin , Huang, Da , Kou, Huari et al. Synthesis and Characterization of Free Radical Scavenging Dendrimer Nanogels via Cross-Linking Reaction-Enabled Flash Nanoprecipitation [J]. | BIOMACROMOLECULES , 2025 , 26 (5) : 2986-2995 . |
| MLA | Qi, Lin et al. "Synthesis and Characterization of Free Radical Scavenging Dendrimer Nanogels via Cross-Linking Reaction-Enabled Flash Nanoprecipitation" . | BIOMACROMOLECULES 26 . 5 (2025) : 2986-2995 . |
| APA | Qi, Lin , Huang, Da , Kou, Huari , Chernatynskaya, Anna , Ercal, Nuran , Yang, Hu . Synthesis and Characterization of Free Radical Scavenging Dendrimer Nanogels via Cross-Linking Reaction-Enabled Flash Nanoprecipitation . | BIOMACROMOLECULES , 2025 , 26 (5) , 2986-2995 . |
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Multifunctional hydrogels hold significant promise for promoting the healing of infected wounds but often fall short in inhibiting antibiotic-resistant pathogens, and their clinical translation is limited by complex preparation processes and high costs. In this study, a multifunctional hydrogel is developed by combining metal-phenolic networks (MPNs) formed by tannic acid (TA) and gallium ions (Ga3+) with chitosan (CS) through a simple one-step method. The resulting CS-TA-Ga3+ (CTG) hydrogel is cost-effective and exhibits desirable properties, including injectability, self-healing, pH responsiveness, hemostasis, antioxidant, anti-inflammatory, and antibacterial activities. Importantly, the CTG hydrogels are effective against antibiotic-resistant pathogens due to the unique antibacterial mechanism of Ga3+. In vivo studies demonstrate that the CTG hydrogel promotes follicle formation and collagen deposition, accelerating the healing of infected wounds by inhibiting blood loss, suppressing bacterial growth, and modulating the inflammatory microenvironment. These findings highlight the CTG hydrogel's potential as an advanced and translational dressing for enhancing the healing of infected wounds.
Keyword ：
antibacterial antibacterial gallium ions gallium ions infected wound healing infected wound healing metal-phenolic network metal-phenolic network multifunctional hydrogel multifunctional hydrogel
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| GB/T 7714 | Zou, Minglang , Chen, Cuiping , Wang, Mingda et al. Facile Fabrication of Injectable Multifunctional Hydrogels Based on Gallium-Polyphenol Networks with Superior Antibacterial Activity for Promoting Infected Wound Healing [J]. | ADVANCED HEALTHCARE MATERIALS , 2025 , 14 (9) . |
| MLA | Zou, Minglang et al. "Facile Fabrication of Injectable Multifunctional Hydrogels Based on Gallium-Polyphenol Networks with Superior Antibacterial Activity for Promoting Infected Wound Healing" . | ADVANCED HEALTHCARE MATERIALS 14 . 9 (2025) . |
| APA | Zou, Minglang , Chen, Cuiping , Wang, Mingda , Lei, Chen , Wang, Yongming , Luo, Fang et al. Facile Fabrication of Injectable Multifunctional Hydrogels Based on Gallium-Polyphenol Networks with Superior Antibacterial Activity for Promoting Infected Wound Healing . | ADVANCED HEALTHCARE MATERIALS , 2025 , 14 (9) . |
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Curcumin (CUR) is a natural polyphenol that holds promise for treating ulcerative colitis (UC), yet oral administration of CUR exhibits limited bioavailability and existing formulations for oral delivery of CUR often suffer from unsatisfactory loading capacity. This study presents hydroxyethyl starch-curcumin microspheres (HCMSs) with excellent CUR loading capacity (54.52 %), and the HC-MSs can further encapsulate anti-inflammatory drugs dexamethasone (DEX) to obtain a combination formulation (DHC-MSs) with high DEX loading capacity (19.91 %), for combination therapy of UC. The microspheres were successfully engineered, retaining the antioxidative and anti-inflammatory activities of parental CUR and demonstrating excellent biocompatibility and controlled release properties, notably triggered by alpha-amylase, facilitating targeted drug delivery to inflamed sites. In a mouse UC model induced by dextran sulfate sodium, the microspheres effectively accumulated in inflamed colons and both HC-MSs and DHC-MSs exhibited superior therapeutic efficacy in alleviating UC symptoms compared to free DEX. Moreover, mechanistic exploration uncovered the multifaceted therapeutic mechanisms of these formulations, encompassing anti-inflammatory actions, mitigation of spleen enlargement, and modulation of gut microbiota composition. These findings underscore the potential of HC-MSs and DHC-MSs as promising formulations for UC, with implications for advancing treatment modalities for various inflammatory bowel disorders.
Keyword ：
Anti-inflammatory Anti-inflammatory Curcumin Curcumin Gut microbiota Gut microbiota Microspheres Microspheres Oral delivery Oral delivery Ulcerative colitis Ulcerative colitis
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| GB/T 7714 | Huang, Da , Wang, Yongming , Xu, Chenlan et al. Colon-targeted hydroxyethyl starch-curcumin microspheres with high loading capacity ameliorate ulcerative colitis via alleviating oxidative stress, regulating inflammation, and modulating gut microbiota [J]. | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES , 2024 , 266 . |
| MLA | Huang, Da et al. "Colon-targeted hydroxyethyl starch-curcumin microspheres with high loading capacity ameliorate ulcerative colitis via alleviating oxidative stress, regulating inflammation, and modulating gut microbiota" . | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 266 (2024) . |
| APA | Huang, Da , Wang, Yongming , Xu, Chenlan , Zou, Minglang , Ming, Yangcan , Luo, Fang et al. Colon-targeted hydroxyethyl starch-curcumin microspheres with high loading capacity ameliorate ulcerative colitis via alleviating oxidative stress, regulating inflammation, and modulating gut microbiota . | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES , 2024 , 266 . |
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Hydrogel dressings capable of infection monitoring and precise treatment administration show promise for advanced wound care. Existing methods involve embedd ingorganic dyes or flexible electronics into preformed hydrogels, which raise safety issues and adaptability challenges. In this study, an injectable hydrogel based smart wound dressing is developed by integrating food-derived anthocyanidin as a visual pH probe for infection monitoring and poly(L-lactic acid) microcapsules as ultrasound-responsive delivery systems for antibiotics into a poly(ethylene glycol) hydrogel. This straightforwardly prepared hydrogel dressing maintains its favorable properties for wound repair, including porous morphology and excellent biocompatibility. In vitro experiments demonstrated that the hydrogel enabled visual assessment of pH within the range of 5 similar to 9.Meanwhile, the release of antibiotics could be triggered and controlled by ultrasound. In vivo evaluations using infected wounds and diabetic wounds revealed that the wound dressing effectively detected wound infection by monitoring pH levels and achieved antibacterial effects through ultrasound-triggered drug release. This led to significantly enhanced wound healing, as validated by histological analysis and the measurement of inflammatory cytokine levels. This injectable hydrogel-based smart wound dressing holds great potential for use in clinical settings to inform timely and precise clinical intervention and in community to improve wound care management. The study presents an injectable hydrogel dressing with flexibility to fit irregularly shaped wounds and excellent biocompatibility for visual monitoring of infection and on-demand treatment. It utilizes food-derived anthocyanidin as a pH probe and poly(L-lactic acid) microcapsules for ultrasound-responsive drug delivery. In diabetic wounds, the dressing detects infections through pH monitoring and enhances healing via ultrasound-triggered drug release.image
Keyword ：
chronic wounds chronic wounds hydrogels hydrogels on-demand treatment on-demand treatment pH detection pH detection ultrasound responsive ultrasound responsive wound monitoring wound monitoring
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| GB/T 7714 | Huang, Da , Du, Jiahao , Luo, Fang et al. Injectable Hydrogels with Integrated Ph Probes and Ultrasound-Responsive Microcapsules as Smart Wound Dressings for Visual Monitoring and On-Demand Treatment of Chronic Wounds [J]. | ADVANCED HEALTHCARE MATERIALS , 2024 , 13 (9) . |
| MLA | Huang, Da et al. "Injectable Hydrogels with Integrated Ph Probes and Ultrasound-Responsive Microcapsules as Smart Wound Dressings for Visual Monitoring and On-Demand Treatment of Chronic Wounds" . | ADVANCED HEALTHCARE MATERIALS 13 . 9 (2024) . |
| APA | Huang, Da , Du, Jiahao , Luo, Fang , He, Gang , Zou, Minglang , Wang, Yongming et al. Injectable Hydrogels with Integrated Ph Probes and Ultrasound-Responsive Microcapsules as Smart Wound Dressings for Visual Monitoring and On-Demand Treatment of Chronic Wounds . | ADVANCED HEALTHCARE MATERIALS , 2024 , 13 (9) . |
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The prescription of a course of oral antibiotics following bone grafting procedures is a common practice in clinical periodontics to reduce surgical site infections. The goal of this study is to characterize the release profile of antibiotics via local delivery using dendrimer hydrogels (DH) and to analyze the effect of two different particulate bone allografts on the release of the antibiotics in vitro. DH were synthesized from polyamidoamine (PAMAM) dendrimer G5 and polyethylene glycol diacrylate, and cefazolin was chosen as the antibiotic. The antibiotic-loaded samples were bathed in PBS and incubated at 37 degrees C; aliquots were taken (1 h, 2 h, 3 h, 4 h, 5 h, 6 h, 12 h, 24 h, 48 h, 72 h) and analyzed using HPLC to determine the amounts of released cefazolin. In samples with DH, the estimated maximum concentration of cefazolin was 36.97 +/- 2.39 mu g/mL (95% CI: 34.58-39.36) with 50% released in 4.17 h (95%: 3.26-5.07) and an estimated growth rate of 0.27 (95% CI: 0.17-0.37). For samples without DH, the estimated maximum concentration of cefazolin was 167.4 +/- 7.0 mu g/mL (95% CI: 160.4-174.4) with 50% released in 2.36 h (95% CI: 2.05-2.67) and an estimated growth rate of 0.70 (95% CI: 0.54-0.87). We conclude that DH are a promising platform for sustained antibiotic release and that the presence of bone grafts did not significantly affect their release.
Keyword ：
antibiotic antibiotic cefazolin cefazolin hydrogel hydrogel local delivery local delivery PAMAM dendrimer PAMAM dendrimer
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| GB/T 7714 | Yesbeck, Nicholas , Huang, Da , Carrico, Caroline et al. Antibiotic-Loaded Dendrimer Hydrogels in Periodontal Bone Regeneration: An In Vitro Release Feasibility Study [J]. | GELS , 2024 , 10 (9) . |
| MLA | Yesbeck, Nicholas et al. "Antibiotic-Loaded Dendrimer Hydrogels in Periodontal Bone Regeneration: An In Vitro Release Feasibility Study" . | GELS 10 . 9 (2024) . |
| APA | Yesbeck, Nicholas , Huang, Da , Carrico, Caroline , Madurantakam, Parthasarathy , Yang, Hu . Antibiotic-Loaded Dendrimer Hydrogels in Periodontal Bone Regeneration: An In Vitro Release Feasibility Study . | GELS , 2024 , 10 (9) . |
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Shape memory cryogels hold immense promise for non-compressible hemostasis due to their shape recovery after contacting with blood. However, there is still a lack of an easy way to accelerate the shape-recovery speed which is highly associated with its performance. Meanwhile, the incorporation of extra pro-coagulation mechanisms will further improve the hemostatic efficacy. Herein, surfactant-stabilized bubbles are used to improve the shape-recovery speed of cryogels (GHP) through the modulation of porosity and pore size based on the capillary action. Additionally, 2D nanosheet vermiculite (VMT) is fabricated and incorporated into the system to get VMT@GHP cryogels. Remarkably, VMT@GHP exhibits a fast shape recovery speed (1.3 +/- 0.3 s in the blood) among reported hemostats and the ability to promote blood coagulation. Animal studies show that VMT@GHP significantly accelerates the hemostasis in both rat and pig models, even in heparinized situations. In summary, VMT@GHP represents a highly effective solution for non-compressible hemorrhage control, with promising prospects for clinical translation.
Keyword ：
cryogel cryogel hemostasis hemostasis non-compressible hemorrhage non-compressible hemorrhage shape memory shape memory vermiculite vermiculite
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| GB/T 7714 | Wang, Binhui , Zhu, Bin , Liu, Yihao et al. Fast Recoverable Shape Memory Cryogels Engineered with Surfactant-Stabilized Bubbles and Vermiculite for Non-Compressible Hemostasis [J]. | ADVANCED FUNCTIONAL MATERIALS , 2024 , 35 (4) . |
| MLA | Wang, Binhui et al. "Fast Recoverable Shape Memory Cryogels Engineered with Surfactant-Stabilized Bubbles and Vermiculite for Non-Compressible Hemostasis" . | ADVANCED FUNCTIONAL MATERIALS 35 . 4 (2024) . |
| APA | Wang, Binhui , Zhu, Bin , Liu, Yihao , Ren, Bowen , Chen, Yurong , Feng, Luyao et al. Fast Recoverable Shape Memory Cryogels Engineered with Surfactant-Stabilized Bubbles and Vermiculite for Non-Compressible Hemostasis . | ADVANCED FUNCTIONAL MATERIALS , 2024 , 35 (4) . |
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A high-efficiency PtZnCd nanozyme was screened with density functional theory (DFT) and unique d-orbital coupling features for sensitive enrichment and real-time analysis of CO-releasing molecule-3 (CORM-3). Multicatalytic sites in the nanozyme showed a high reactivity of up to 72.89 min-1 for peroxidase (POD)-like reaction, which was 2.2, 4.07, and 14.67 times higher than that of PtZn (32.67 min-1), PtCd (17.89 min-1), and Pt (4.97 min-1), respectively. Normalization of the catalytic sites showed that the catalytic capacity of the active site in PtZnCd was 2.962 U mu mol-1, which was four times higher than that of a pure Pt site (0.733 U mu mol-1). DFT calculations showed that improved d-orbital coupling between different metals reduces the position of the center of the shifted whole d-band relative to the Fermi energy level, thereby increasing the contribution of the sites to the electron transfer from the active center, accompanied by enhanced substrate adsorption and intermediate conversion in the catalytic process. The potential adsorption principle and color development mechanism of CORM-3 on PtZnCd were determined, and its practical application in drug metabolism was validated in vitro and in zebrafish and mice models, demonstrating that transition-metal doping effectively engineers high-performance nanozymes and optimizes artificial enzymes.
Keyword ：
nanozymes nanozymes peroxidase-like activity peroxidase-like activity pharmacovigilance pharmacovigilance platinum catalysts platinum catalysts
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| GB/T 7714 | Yu, Zhichao , Xu, Zhenjin , Zeng, Ruijin et al. D-Band-Center-Engineered Platinum-Based Nanozyme for Personalized Pharmacovigilance [J]. | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION , 2024 , 64 (2) . |
| MLA | Yu, Zhichao et al. "D-Band-Center-Engineered Platinum-Based Nanozyme for Personalized Pharmacovigilance" . | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 64 . 2 (2024) . |
| APA | Yu, Zhichao , Xu, Zhenjin , Zeng, Ruijin , Xu, Man , Zheng, Haisu , Huang, Da et al. D-Band-Center-Engineered Platinum-Based Nanozyme for Personalized Pharmacovigilance . | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION , 2024 , 64 (2) . |
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The global crisis of bacterial infections is exacerbated by the escalating threat of microbial antibiotic resistance. Nanozymes promise to provide ingenious solutions. Here, we reported a homogeneous catalytic structure of Pt nanoclusters with finely tuned metal-organic framework (ZIF-8) channel structures for the treatment of infected wounds. Catalytic site normalization showed that the active site of the Pt aggregates structure with fine-tuned pore modifications structure had a catalytic capacity of 14.903x105 min-1, which was 18.7 times higher than that of the Pt particles in monodisperse state in ZIF-8 (0.793x105 min-1). In situ tests revealed that the change from homocleavage to heterocleavage of hydrogen peroxide at the interface of the nanozyme was one of the key reasons for the improvement of nanozyme activity. Density-functional theory and kinetic simulations of the reaction interface jointly determine the role of the catalytic center and the substrate channel together. Metabolomics analysis showed that the developed nanozyme, working in conjunction with reactive oxygen species, could effectively block energy metabolic pathways within bacteria, leading to spontaneous apoptosis and bacterial rupture. This pioneering study elucidates new ideas for the regulation of artificial enzyme activity and provides new perspectives for the development of efficient antibiotic substitutes.
Keyword ：
bacterial energy metabolism pathways bacterial energy metabolism pathways density functional theory density functional theory metal-organic framework metal-organic framework nanozyme nanozyme platinum catalysts platinum catalysts
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| GB/T 7714 | Yu, Zhichao , Xu, Zhenjin , Zeng, Ruijin et al. Tailored Metal-Organic Framework-Based Nanozymes for Enhanced Enzyme-Like Catalysis [J]. | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION , 2024 , 64 (7) . |
| MLA | Yu, Zhichao et al. "Tailored Metal-Organic Framework-Based Nanozymes for Enhanced Enzyme-Like Catalysis" . | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 64 . 7 (2024) . |
| APA | Yu, Zhichao , Xu, Zhenjin , Zeng, Ruijin , Xu, Man , Zou, Minglang , Huang, Da et al. Tailored Metal-Organic Framework-Based Nanozymes for Enhanced Enzyme-Like Catalysis . | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION , 2024 , 64 (7) . |
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Drug repurposing uses approved drugs as candidate anticancer therapeutics, harnesses previous research and development efforts, and benefits from available clinically suitable formulations and evidence of patient tolerability. In this work, the drug used clinically to treat chronic alcoholism, disulfiram (DSF), was studied for its antitumor efficacy in a copper-dependent manner. The combination of DSF and copper could achieve a tumor cell growth inhibition effect comparable to those of 5-fluorouracil and taxol on head and neck cancer cells. Both bulk dendrimer hydrogel and microsized dendrimer hydrogel particles were utilized for the localized sustained release of copper in the tumor site. The localized sustained release of copper facilitated the tumor inhibition effect following intratumoral injection in a mouse's head and neck cancer model.
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| GB/T 7714 | Wang, Juan , Li, Boxuan , Cooper, Remy C. et al. Localized Sustained Release of Copper Enhances Antitumor Effects of Disulfiram in Head and Neck Cancer [J]. | BIOMACROMOLECULES , 2024 , 25 (5) : 2770-2779 . |
| MLA | Wang, Juan et al. "Localized Sustained Release of Copper Enhances Antitumor Effects of Disulfiram in Head and Neck Cancer" . | BIOMACROMOLECULES 25 . 5 (2024) : 2770-2779 . |
| APA | Wang, Juan , Li, Boxuan , Cooper, Remy C. , Huang, Da , Yang, Hu . Localized Sustained Release of Copper Enhances Antitumor Effects of Disulfiram in Head and Neck Cancer . | BIOMACROMOLECULES , 2024 , 25 (5) , 2770-2779 . |
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