As　the　effective　photothermal　agent,　NIR　cyanine　dye　has　shown　great　promise　in　cancer　therapy　due　to　its　distinct　NIR　absorbance　and　excellent　thermal　conversion　superiority.　Up　to　date,　various　nanosystems　have　been　developed　as　the　delivery　carrier　for　NIR　dye　in　order　to　overcome　the　inherent　issues　such　as　poor　stability,　low　bioavailability　and　insufficient　therapy　efficacy.　However,　the　huge　obstacle　of　current　nanocarriers　for　NIR　dye　encapsulation　frequently　lies　in　high　leakage　risk,　complicated　preparation　and　poor　biocompatibility,　which　significantly　hinder　their　further　application　in　cancer　therapy.　To　make　up　for　these　deficiencies,　we　developed　a　facile　and　universal　strategy　to　fabricate　a　novel　nanoscale　coordination　polymers　(NCPs)　through　the　co　coordination　driven　assembly　of　cypate　and　carboxyl　ligand　with　Gd3+.　Through　this　design,　cypate　can　be　effectively　introduced　into　the　interior　of　NCPs　through　the　coordination　between　its　carboxyl　group　and　Gd3+,　resulting　in　the　enhanced　stability,　reduced　leakage　risk,　and　improved　therapeutic　efficacy.　The　fabricated　NCPs　have　exhibited　multimodal　imaging　guided　tumor　targeting　chemo-photothermal　property.　After　accumulation　in　tumor　site,　rapid　drug　release　can　be　effectively　triggered　by　NIR　laser　induced　hyperthermia　and　acidic　endo/　lysosomal　microenvironment,　which　fundamentally　improved　the　synergistic　chemo-photothermal　efficacy　for　tumor　killing.　The　newly　fabricated　NCP　system　can　exert　distinctively　chemo-photothermal　synergistic　efficacy　for　cancer　therapy　and　will　pave　a　new　avenue　for　the　application　of　NCPs　in　biomedical　field.