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学者姓名：刘春
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Abstract ：
Holliday junction (HJ) is a four-way structured DNA intermediate in processes of homologous recombination and DNA double-stranded break (DSB) repair. In bacteria, HJs are processed via either the RuvABC or RecGdependent pathways. In addition, RecG also plays a critical role in the reactivation of stalled replication forks, making it an attractive target for antibacterial drug development. Here, we conducted a high-throughput screening targeting the RecG helicase from a common opportunistic pathogen Pseudomonas aeruginosa (Pa). From a library containing 7920 compounds, we identified Ebselen and TPI-1 (2 ',5 '-Dichloro-[1,1 '-biphenyl]-2,5dione) as two potent PaRecG inhibitors, with IC50 values of 0.31 +/- 0.02 mu M and 1.16 +/- 0.06 mu M, respectively. Further biochemical analyses suggested that both Ebselen and TPI-1 inhibited the ATPase activity of PaRecG, and hindered its binding to HJ DNA with high selectivity. These compounds, when combined with our previously reported RuvAB inhibitors, resulted in more severe DNA repair defects than the individual treatment, and potently enhanced the susceptibility of P. aeruginosa to the DNA damage agents. This work reports novel small molecule inhibitors of RecG, offering valuable chemical tools for advancing our understanding of RecG's function and mechanism. Additionally, these inhibitors might be further developed as promising antibacterial agents in the fight against P. aeruginosa infections.
Keyword ：
Combined effect Combined effect DNA damage repair DNA damage repair Holliday junction Holliday junction Pseudomonas aeruginosa Pseudomonas aeruginosa RecG RecG Small-molecule inhibitors Small-molecule inhibitors
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| GB/T 7714 | Li, Longheng , Guo, Binbin , Dai, Lin et al. Ebselen and TPI-1, as RecG helicase inhibitors, potently enhance the susceptibility of Pseudomonas aeruginosa to DNA damage agents [J]. | BIOCHEMICAL PHARMACOLOGY , 2024 , 222 . |
| MLA | Li, Longheng et al. "Ebselen and TPI-1, as RecG helicase inhibitors, potently enhance the susceptibility of Pseudomonas aeruginosa to DNA damage agents" . | BIOCHEMICAL PHARMACOLOGY 222 (2024) . |
| APA | Li, Longheng , Guo, Binbin , Dai, Lin , Liu, Chun , Lin, Zhonghui . Ebselen and TPI-1, as RecG helicase inhibitors, potently enhance the susceptibility of Pseudomonas aeruginosa to DNA damage agents . | BIOCHEMICAL PHARMACOLOGY , 2024 , 222 . |
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The MUS81-EME1/2 structure-specific endonucleases play a crucial role in the processing of stalled replication forks and recombination intermediates, and have been recognized as an attractive drug target to potentiate the anti-cancer efficacy of DNA-damaging agents. Currently, no bioactive small-molecule inhibitors of MUS81 are available. Here, we performed a high-throughput small-molecule inhibitors screening, using the FRET-based DNA cleavage assay. From 7920 compounds, we identified dyngo-4a as a potent inhibitor of MUS81 complexes. Dyngo-4a effectively inhibits the endonuclease activities of both MUS81-EME1 and MUS81-EME2 complexes, with IC50 values of 0.57 mu M and 2.90 & mu;M, respectively. Surface plasmon resonance (SPR) and electrophoretic mobility shift assay (EMSA) assays reveal that dyngo-4a directly binds to MUS81 complexes (KD similar to 0.61 mu M) and prevents them from binding to DNA substrates. In HeLa cells, dyngo-4a significantly suppresses bleomycin-triggered H2AX serine 139 phosphorylation (gamma H2AX). Together, our results demonstrate that dyngo4a is a potent MUS81 inhibitor, which could be further developed as a potentially valuable chemical tool to explore more physiological roles of MUS81 in the cells.
Keyword ：
Dynasore Dynasore Dyngo-4a Dyngo-4a EME1 EME1 EME2 EME2 MUS81 MUS81 Small-molecule inhibitor Small-molecule inhibitor
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| GB/T 7714 | Zhang, Xu , Chen, Xuening , Lu, Lian et al. Identification of small-molecule inhibitors of human MUS81-EME1/2 by FRET-based high-throughput screening [J]. | BIOORGANIC & MEDICINAL CHEMISTRY , 2023 , 90 . |
| MLA | Zhang, Xu et al. "Identification of small-molecule inhibitors of human MUS81-EME1/2 by FRET-based high-throughput screening" . | BIOORGANIC & MEDICINAL CHEMISTRY 90 (2023) . |
| APA | Zhang, Xu , Chen, Xuening , Lu, Lian , Fang, Qianqian , Liu, Chun , Lin, Zhonghui . Identification of small-molecule inhibitors of human MUS81-EME1/2 by FRET-based high-throughput screening . | BIOORGANIC & MEDICINAL CHEMISTRY , 2023 , 90 . |
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As the effective photothermal agent, NIR cyanine dye has shown great promise in cancer therapy due to its distinct NIR absorbance and excellent thermal conversion superiority. Up to date, various nanosystems have been developed as the delivery carrier for NIR dye in order to overcome the inherent issues such as poor stability, low bioavailability and insufficient therapy efficacy. However, the huge obstacle of current nanocarriers for NIR dye encapsulation frequently lies in high leakage risk, complicated preparation and poor biocompatibility, which significantly hinder their further application in cancer therapy. To make up for these deficiencies, we developed a facile and universal strategy to fabricate a novel nanoscale coordination polymers (NCPs) through the co coordination driven assembly of cypate and carboxyl ligand with Gd3+. Through this design, cypate can be effectively introduced into the interior of NCPs through the coordination between its carboxyl group and Gd3+, resulting in the enhanced stability, reduced leakage risk, and improved therapeutic efficacy. The fabricated NCPs have exhibited multimodal imaging guided tumor targeting chemo-photothermal property. After accumulation in tumor site, rapid drug release can be effectively triggered by NIR laser induced hyperthermia and acidic endo/ lysosomal microenvironment, which fundamentally improved the synergistic chemo-photothermal efficacy for tumor killing. The newly fabricated NCP system can exert distinctively chemo-photothermal synergistic efficacy for cancer therapy and will pave a new avenue for the application of NCPs in biomedical field.
Keyword ：
Chemo-photothermal therapy Chemo-photothermal therapy Multimodal imaging Multimodal imaging Nanoscale coordination polymer Nanoscale coordination polymer NIR-responsive NIR-responsive pH-sensitive pH-sensitive
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| GB/T 7714 | Chen, Mingmao , Li, Ruyue , Liu, Yan et al. Near infrared and pH dual-activated coordination polymer nanosystem for imaging-guided chemo-photothermal therapy [J]. | CHEMICAL ENGINEERING JOURNAL , 2021 , 406 . |
| MLA | Chen, Mingmao et al. "Near infrared and pH dual-activated coordination polymer nanosystem for imaging-guided chemo-photothermal therapy" . | CHEMICAL ENGINEERING JOURNAL 406 (2021) . |
| APA | Chen, Mingmao , Li, Ruyue , Liu, Yan , Song, Xiaorong , Tian, Jia , Fu, Yulei et al. Near infrared and pH dual-activated coordination polymer nanosystem for imaging-guided chemo-photothermal therapy . | CHEMICAL ENGINEERING JOURNAL , 2021 , 406 . |
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Dengue virus (DENV) is a small envelope virus of Flaviviridae that is mainly transmitted by Aedes aegypti and Aedes albopictus. It can cause dengue fever with mild clinical symptoms or even life-threatening dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS). At present, there are no specific drugs or mature vaccine products to treat DENV. microRNAs (miRNAs) are a class of important non-coding small molecular RNAs that regulate gene expression at the post-transcriptional level. It is involved in and regulates a series of important life processes, such as growth and development, cell differentiation, cell apoptosis, anti-virus, and anti-tumor. miRNAs also play important roles in interactions between host and viral genome transcriptomes. Host miRNAs can directly target the genome of the virus or regulate host factors to promote or inhibit virus replication. Understanding the expression and function of miRNAs during infection with DENV and the related signal molecules of the miRNA-mediated regulatory network will provide new insights for the development of miRNA-based therapies.
Keyword ：
dengue virus dengue virus hostpathogen interaction hostpathogen interaction microRNA microRNA signaling/signaling pathways signaling/signaling pathways virus replication virus replication
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| GB/T 7714 | Su, Yinghua , Lin, Ting , Liu, Chun et al. microRNAs, the Link Between Dengue Virus and the Host Genome [J]. | FRONTIERS IN MICROBIOLOGY , 2021 , 12 . |
| MLA | Su, Yinghua et al. "microRNAs, the Link Between Dengue Virus and the Host Genome" . | FRONTIERS IN MICROBIOLOGY 12 (2021) . |
| APA | Su, Yinghua , Lin, Ting , Liu, Chun , Cheng, Cui , Han, Xiao , Jiang, Xiwen . microRNAs, the Link Between Dengue Virus and the Host Genome . | FRONTIERS IN MICROBIOLOGY , 2021 , 12 . |
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As a special type of noncoding RNA, circular RNAs (circRNAs) are prevalent in many organisms. They can serve as sponges for microRNAs and protein scaffolds, or templates for protein translation, making them linked to cellular homeostasis and disease progression. In recent years, circRNAs have been found to be abnormally expressed during the processes of viral infection and pathogenesis, and can help a virus escape the immune response of a host. Thus, they are now considered to play important functions in the invasion and development of viruses. Moreover, the potential application of circRNAs as biomarkers of viral infection or candidates for therapeutic targeting deserves consideration. This review summarizes circRNAs in the transcriptome, including their classification, production, functions, and value as biomarkers. This review paper also describes research progress on circRNAs in viral infection (mainly hepatitis B virus, HIV, and some human herpes viruses) and aims to provide new ideas for antiviral therapies targeting circRNAs.
Keyword ：
circRNAs circRNAs HBV HBV HIV HIV ncRNAs ncRNAs virus virus
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| GB/T 7714 | Lou, Zhihao , Zhou, Rui , Su, Yinghua et al. Minor and major circRNAs in virus and host genomes [J]. | JOURNAL OF MICROBIOLOGY , 2021 , 59 (3) : 324-331 . |
| MLA | Lou, Zhihao et al. "Minor and major circRNAs in virus and host genomes" . | JOURNAL OF MICROBIOLOGY 59 . 3 (2021) : 324-331 . |
| APA | Lou, Zhihao , Zhou, Rui , Su, Yinghua , Liu, Chun , Ruan, Wenting , Jeon, Che Ok et al. Minor and major circRNAs in virus and host genomes . | JOURNAL OF MICROBIOLOGY , 2021 , 59 (3) , 324-331 . |
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Hepatocellular carcinoma (HCC) is a malignant tumor with the highest mortality rate in the world, and hepatitis B virus (HBV) plays an important role in its development. Long noncoding RNA (lncRNA) is highly related to the inactivation of tumor suppressor genes and the activation of oncogenes in HCC. Researchers have used high-throughput sequencing technology to identify many noncoding transcripts related to the development of HCC and have studied the interaction between these transcripts and DNA, RNA, or protein to determine the relevant mechanism in the development of HCC. In general, the research on lncRNA represents a new field of cancer research, and the imbalance in lncRNA plays an pivotal role in the occurrence of liver cancer. In this review, we summarize some of the dysfunctional lncRNAs in human HCC associated with HBV infection. Their regulatory pathways, functions, and potential molecular mechanisms in the occurrence and development of HCC are discussed.
Keyword ：
HBx protein HBx protein hepatitis B virus hepatitis B virus hepatocellular carcinoma hepatocellular carcinoma lncRNA lncRNA microRNA microRNA
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| GB/T 7714 | Wang, Xueke , Kang, Meisong , Liu, Chun et al. Current State and Progress of Research on the Role of lncRNA in HBV-Related Liver Cancer [J]. | FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY , 2021 , 11 . |
| MLA | Wang, Xueke et al. "Current State and Progress of Research on the Role of lncRNA in HBV-Related Liver Cancer" . | FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY 11 (2021) . |
| APA | Wang, Xueke , Kang, Meisong , Liu, Chun , Lin, Ting , Han, Xiao , Jiang, Xiwen . Current State and Progress of Research on the Role of lncRNA in HBV-Related Liver Cancer . | FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY , 2021 , 11 . |
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Cyclodextrins (CDs) are a series of cyclic oligosaccharides formed by amylose under the action of CD glucosyltransferase that is produced by Bacillus. After being modified by polymerization, substitution and grafting, high molecular weight cyclodextrin polymers (pCDs) containing multiple CD units can be obtained. pCDs retain the internal hydrophobic-external hydrophilic cavity structure characteristic of CDs, while also possessing the stability of polymer. They are a class of functional polymer materials with strong development potential and have been applied in many fields. This review introduces the research progress of pCDs, including the synthesis of pCDs and their applications in analytical separation science, materials science, and biomedicine.
Keyword ：
biomedicine biomedicine cyclodextrin polymers cyclodextrin polymers materials science materials science separation science separation science synthesis synthesis
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| GB/T 7714 | Liu, Yuan , Lin, Ting , Cheng, Cui et al. Research Progress on Synthesis and Application of Cyclodextrin Polymers [J]. | MOLECULES , 2021 , 26 (4) . |
| MLA | Liu, Yuan et al. "Research Progress on Synthesis and Application of Cyclodextrin Polymers" . | MOLECULES 26 . 4 (2021) . |
| APA | Liu, Yuan , Lin, Ting , Cheng, Cui , Wang, Qiaowen , Lin, Shujin , Liu, Chun et al. Research Progress on Synthesis and Application of Cyclodextrin Polymers . | MOLECULES , 2021 , 26 (4) . |
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Photodynamic therapy (PDT) is a promising therapy due to its efficiency and accuracy. The photosensitizer is delivered to the target lesion and locally activated. Viral nanoparticles (VNPs) have been explored as delivery vehicles for PDT in recent years because of their favorable properties, including simple manufacture and good safety profile. They have great potential as drug delivery carriers in medicine. Here, we review the development of PDT photosensitizers and discuss applications of VNP-mediated photodynamic therapies and the performance of VNPs in the treatment of tumor cells and antimicrobial therapy. Furthermore, future perspectives are discussed for further developing novel viral nanocarriers or improving existing viral vectors.
Keyword ：
photodynamic therapy photodynamic therapy photosensitizer photosensitizer viral nanoparticles viral nanoparticles
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| GB/T 7714 | Lin, Shujin , Liu, Chun , Han, Xiao et al. Viral Nanoparticle System: An Effective Platform for Photodynamic Therapy [J]. | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES , 2021 , 22 (4) . |
| MLA | Lin, Shujin et al. "Viral Nanoparticle System: An Effective Platform for Photodynamic Therapy" . | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 22 . 4 (2021) . |
| APA | Lin, Shujin , Liu, Chun , Han, Xiao , Zhong, Haowei , Cheng, Cui . Viral Nanoparticle System: An Effective Platform for Photodynamic Therapy . | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES , 2021 , 22 (4) . |
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Prussian blue nanoparticles (PBNPs) have attracted increasing research interest in immunosensors, bioimaging, drug delivery, and application as therapeutic agents due to their large internal pore volume, tunable size, easy synthesis and surface modification, good thermal stability, and favorable biocompatibility. This review first outlines the effect of tumor markers using PBNPs-based immunosensors which have a sandwich-type architecture and competitive-type structure. Metal ion doped PBNPs which were used as T-1-weight magnetic resonance and photoacoustic imaging agents to improve image quality and surface modified PBNPs which were used as drug carriers to decrease side effects via passive or active targeting to tumor sites are also summarized. Moreover, the PBNPs with high photothermal efficiency and excellent catalase-like activity were promising for photothermal therapy and O-2 self-supplied photodynamic therapy of tumors. Hence, PBNPs-based multimodal imaging-guided combinational tumor therapies (such as chemo, photothermal, and photodynamic therapies) were finally reviewed. This review aims to inspire broad interest in the rational design and application of PBNPs for detecting and treating tumors in clinical research.
Keyword ：
drug delivery drug delivery imaging imaging imaging-guided therapy imaging-guided therapy immunosensors immunosensors Prussian blue nanoparticles Prussian blue nanoparticles
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| GB/T 7714 | Gao, Xiaoran , Wang, Qiaowen , Cheng, Cui et al. The Application of Prussian Blue Nanoparticles in Tumor Diagnosis and Treatment [J]. | SENSORS , 2020 , 20 (23) . |
| MLA | Gao, Xiaoran et al. "The Application of Prussian Blue Nanoparticles in Tumor Diagnosis and Treatment" . | SENSORS 20 . 23 (2020) . |
| APA | Gao, Xiaoran , Wang, Qiaowen , Cheng, Cui , Lin, Shujin , Lin, Ting , Liu, Chun et al. The Application of Prussian Blue Nanoparticles in Tumor Diagnosis and Treatment . | SENSORS , 2020 , 20 (23) . |
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In recent years, researchers across various fields have shown a keen interest in the exploitation of biocompatible natural polymer materials, especially the development and application of seaweed polysaccharides. Seaweed polysaccharides are a multi-component mixture composed of one or more monosaccharides, which have the functions of being anti-virus, anti-tumor, anti-mutation, anti-radiation and enhancing immunity. These biological activities allow them to be applied in various controllable and sustained anti-inflammatory and anticancer drug delivery systems, such as seaweed polysaccharide-based nanoparticles, microspheres and gels, etc. This review summarizes the advantages of alginic acid, carrageenan and other seaweed polysaccharides, and focuses on their application in gel drug delivery systems (such as nanogels, microgels and hydrogels). In addition, recent literature reports and applications of seaweed polysaccharides are also discussed.
Keyword ：
alginic acid alginic acid carrageenan carrageenan drug delivery drug delivery gels gels seaweed polysaccharides seaweed polysaccharides
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| GB/T 7714 | Zhong, Haowei , Gao, Xiaoran , Cheng, Cui et al. The Structural Characteristics of Seaweed Polysaccharides and Their Application in Gel Drug Delivery Systems [J]. | MARINE DRUGS , 2020 , 18 (12) . |
| MLA | Zhong, Haowei et al. "The Structural Characteristics of Seaweed Polysaccharides and Their Application in Gel Drug Delivery Systems" . | MARINE DRUGS 18 . 12 (2020) . |
| APA | Zhong, Haowei , Gao, Xiaoran , Cheng, Cui , Liu, Chun , Wang, Qiaowen , Han, Xiao . The Structural Characteristics of Seaweed Polysaccharides and Their Application in Gel Drug Delivery Systems . | MARINE DRUGS , 2020 , 18 (12) . |
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