The　development　of　multifunctional　therapies　with　targeted　release　materials　is　desirable　for　overcoming　the　high　aggressiveness　and　poor　prognosis　of　triple-negative　breast　cancer　(TNBC).　Herein,　we　have　designed　a　self-　assembled　supramolecule　(BSD),　in　which　SWNTs　can　be　wrapped　by　triple-helix　beta-Glucan　(BFP)　in　a　self-　assembled　manner,　and　doxorubicin　(DOX)　is　attached　onto　SWNTs　by　means　of　it-stacking　and　hydrophobic　interactions　with　high　drug　encapsulation　efficiency　(89.3　%).　BFP　could　significantly　improve　the　dispersion　and　stability　of　SWNTs　and　DOX,　and　reduce　toxicity.　BSD　provides　a　drug-targeting　mechanism　due　to　the　pH-　responsive　and　near-infrared　radiation　(NIR)　thermal-responsive　release　of　DOX,　and　BSD　displayed　excellent　photo-thermal　conversion　effect　and　cyclic　stability,　and　exhibited　higher　antitumor　activity　under　near-infrared　radiation　than　chemotherapy　alone.　Photothermal　therapy　mainly　blocked　the　synthesis　of　nutrients　required　for　tumor　DNA　replication,　while　chemotherapy　markedly　induced　oxidative　stress　production,　which　ultimately　exacerbated　DNA　damage　of　tumor　cells.　As　a　result,　the　combined　effect　of　chemo-photothermal　therapy　ultimately　promote　tumor　cell　apoptosis　and　suppress　the　growth　of　primary　tumor　and　metastasis　to　the　lungs　in　vitro　and　in　vivo.　This　study　provides　a　promising　pH/NIR　thermal-responsive　sustained　prodrug　for　combined　chemo-photothermal　therapy　against　aggressive　triple　negative　breast　cancer　in　practical　therapy.