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学者姓名：宋晓荣
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Nanomaterials that engage in well-defined and tunable interactions with proteins are pivotal for the development of advanced applications. Achieving a precise molecular-level understanding of nano-bio interactions is essential for establishing these interactions. However, such an understanding remains challenging and elusive. Here, we identified stoichiometric interactions of water-soluble gold nanoparticles (Au NPs) with bovine serum albumin (BSA), unraveling their synergism in manipulating emission of nano-bio conjugates in the second near-infrared (NIR-II) regime. Using Au25(p-MBS)18 (p-MBS = para-mercaptobenzenesulfonic acid) as paradigm particles, we achieved precise binding of Au NPs to BSA with definitive molar ratios of 1:1 and 2:1, which is unambiguously evidenced by high-resolution mass spectrometry and transmission electron microscopy. Molecular dynamics simulations identified well-defined binding sites, mediated by electrostatic interactions and hydrogen bonds between the p-MBS moieties on the Au25(p-MBS)18 surface and BSA. Particularly, positively charged residues on BSA were found to be pivotal. By careful control of the molar ratio of Au25(p-MBS)18 to BSA, atomically precise [Au25(p-MBS)18] x -BSA conjugates (x = 1 or 2) could be formed. Through a comprehensive spectroscopy study, an electron transfer process and synergistic effect were manifested in the Au25(p-MBS)18-BSA conjugates, leading to drastically enhanced emission in the NIR-II window. This work offers insights into the precise engineering of nanomaterial-protein interactions and opens new avenues for the development of next-generation nano-bio conjugates for nanotheranostics.
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| GB/T 7714 | Zhang, Bihan , Matus, Maria Francisca , Yao, Qiaofeng et al. Unraveling the Stoichiometric Interactions and Synergism between Ligand-Protected Gold Nanoparticles and Proteins [J]. | JOURNAL OF THE AMERICAN CHEMICAL SOCIETY , 2025 , 147 (8) : 6404-6414 . |
| MLA | Zhang, Bihan et al. "Unraveling the Stoichiometric Interactions and Synergism between Ligand-Protected Gold Nanoparticles and Proteins" . | JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 147 . 8 (2025) : 6404-6414 . |
| APA | Zhang, Bihan , Matus, Maria Francisca , Yao, Qiaofeng , Song, Xiaorong , Wu, Zhennan , Hu, Wenping et al. Unraveling the Stoichiometric Interactions and Synergism between Ligand-Protected Gold Nanoparticles and Proteins . | JOURNAL OF THE AMERICAN CHEMICAL SOCIETY , 2025 , 147 (8) , 6404-6414 . |
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Metal nanoclusters (MNCs) can be synthesized with atomically precise structures and molecule formulae due to the rapid development of nanocluster science in recent decades. The ultrasmall size range (normally < 2 nm) endows MNCs with plenty of molecular-like properties, among which photoluminescent properties have aroused extensive attention. Tracing the research and development processes of luminescent nanoclusters, various photoluminescent analysis and characterization methods play a significant role in elucidating luminescent mechanism and analyzing luminescent properties. In this review, it is aimed to systematically summarize the normally used photoluminescent characterizations in MNCs including basic parameters and methods, such as excitation/emission wavelength, quantum yield, and lifetime. For each key parameter, first its definition and meaning is introduced and then the relevant characterization methods including measuring principles and the revelation of luminescent properties from the collected data are discussed. Then, it is discussed in details how to explore the luminescent mechanism of MNCs and construct NC-based applications based on the measured data. By means of these characterization strategies, the luminescent properties of MNCs and NC-based designs can be explained quantitatively and qualitatively. Hence, this review is expected to provide clear guidance for researchers to characterize luminescent MNCs and better understand the luminescent mechanism from the measured results.
Keyword ：
luminescent properties luminescent properties metal nanoclusters metal nanoclusters photoluminescence photoluminescence photoluminescent characterization photoluminescent characterization photoluminescent lifetime photoluminescent lifetime
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| GB/T 7714 | Lin, Hongbin , Song, Xiaorong , Chai, Osburg Jin Huang et al. Photoluminescent Characterization of Metal Nanoclusters: Basic Parameters, Methods, and Applications [J]. | ADVANCED MATERIALS , 2024 , 36 (25) . |
| MLA | Lin, Hongbin et al. "Photoluminescent Characterization of Metal Nanoclusters: Basic Parameters, Methods, and Applications" . | ADVANCED MATERIALS 36 . 25 (2024) . |
| APA | Lin, Hongbin , Song, Xiaorong , Chai, Osburg Jin Huang , Yao, Qiaofeng , Yang, Huanghao , Xie, Jianping . Photoluminescent Characterization of Metal Nanoclusters: Basic Parameters, Methods, and Applications . | ADVANCED MATERIALS , 2024 , 36 (25) . |
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Gold nanoclusters (AuNCs) are emerging as promising functional probes for bioapplications. However, because of rapid renal clearance, it is a challenge to tailor their biofate and improve their disease-targeting ability in vivo. Herein, we report an efficient strategy to tailor their organotropic actions by rationally designing AuNC assemblies. The nanocluster assembly is established based on the moderate electrostatic interaction or strong coordination between AuNCs, enabled by solely chitosan (CS) or the coadded chelating metal ions (e.g., Gd3+). We show that AuNCs-CS is rapidly excreted into urine, while further coordination of Gd3+ confers assemblies with liver and lung accumulation capabilities, dependent on Gd3+ contents. The organotropic actions are unraveled to result from their tunable stability in vivo and binding capability to cells/proteins. We also demonstrate that lung-targeting assemblies can enable specific NIR-II luminescence imaging of lung orthotopic tumors, which cannot be realized by employing discrete AuNCs. We anticipate that these findings will offer insights into the design principles of metal nanocluster probes and related bioapplications.
Keyword ：
gold clusters gold clusters in vivo imaging in vivo imaging luminescence imaging luminescence imaging metal nanoclusters metal nanoclusters nanoprobe nanoprobe
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| GB/T 7714 | Song, Xiaorong , Wei, Jing , Cai, Xiyang et al. Organotropic Engineering of Luminescent Gold Nanoclusters for In Vivo Imaging of Lung Orthotopic Tumors [J]. | ACS NANO , 2024 , 18 (49) : 33555-33565 . |
| MLA | Song, Xiaorong et al. "Organotropic Engineering of Luminescent Gold Nanoclusters for In Vivo Imaging of Lung Orthotopic Tumors" . | ACS NANO 18 . 49 (2024) : 33555-33565 . |
| APA | Song, Xiaorong , Wei, Jing , Cai, Xiyang , Liu, Yizhuo , Wu, Fengbo , Tong, Shufen et al. Organotropic Engineering of Luminescent Gold Nanoclusters for In Vivo Imaging of Lung Orthotopic Tumors . | ACS NANO , 2024 , 18 (49) , 33555-33565 . |
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For malignant tumor phototherapy, current biomolecules-based materials face challenges such as limited tissue penetration, insufficient tumor accumulation, and overlook of the unique benefits of chirality, thus hampering their phototherapeutic efficiency. Herein, we introduce a novel near-infrared circularly polarized (NIR-CP) light-responsive hybrid CuInSe2@ZnS (CISe@ZnS) quantum dots (QDs) hydrogel (QDs@L/D-Gel), which showcases distinctive NIR chiroptical activity, highly enhanced tumor retention, and superior photothermal/photodynamic properties. Particularly, the QDs@L-Gel exhibits a prominently improved photothermal conversion efficiency (PCE) of 43 % and elevated reactive oxygen species (ROS) upon 808-nm CP light irradiation, outperforming those of linearly polarized light directly emitted from a laser device. Moreover, a remarkably enhanced phototherapeutic efficacy (tumor inhibition rate = 83 %) can be achieved for QDs@L-Gel treated mice after 808-nm CP light treatment, without any toxic side effects. Our findings highlight the importance of supramolecular chirality in NIR-CP-mediated phototherapy, thereby paving a new avenue for more advanced and effective tumor treatment in clinical applications. © 2024 Elsevier Ltd
Keyword ：
CuInSe2 CuInSe2 Near-infrared Near-infrared Phototherapy Phototherapy Self-assembly Self-assembly Supramolecular chirality Supramolecular chirality
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| GB/T 7714 | Gao, H. , Liu, Y. , Lian, W. et al. Near-infrared circularly polarized light triggered phototherapy based on hybrid CuInSe2 quantum dot hydrogels [J]. | Nano Today , 2024 , 58 . |
| MLA | Gao, H. et al. "Near-infrared circularly polarized light triggered phototherapy based on hybrid CuInSe2 quantum dot hydrogels" . | Nano Today 58 (2024) . |
| APA | Gao, H. , Liu, Y. , Lian, W. , Hu, P. , Shang, X. , Chen, M. et al. Near-infrared circularly polarized light triggered phototherapy based on hybrid CuInSe2 quantum dot hydrogels . | Nano Today , 2024 , 58 . |
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Mechanofluorochromic materials are a type of 'smart' material because of their adjustable fluorescent properties under external mechanical force, making them significant members of the materials family. However, as the fluorescent characteristics of these materials highly depend on their microstructures, the still insufficiently in-depth research linking molecular structures to light emission motivates researchers to explore the fluorescent properties of these materials under external stimuli. In this work, based on synthetic [AgS4] microplates, we explore a fascinating mechanical-induced photoluminescent enhancement phenomenon. By applying mechanical force to solid-state [AgS4] to damage the surface morphology, a significant enhancement in photoluminescence is observed. Moreover, the emitted intensity increases with the extent of damage, which can be attributed to alterations in crystallinity. This work provides valuable insights into the relationship among photoluminescence, crystallinity, and mechanical force, offering new strategies for designing luminescent devices. © 2024 American Chemical Society.
Keyword ：
Crystallinity Crystallinity Fluorescence Fluorescence Morphology Morphology Photoluminescence Photoluminescence Surface morphology Surface morphology
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| GB/T 7714 | Lin, Hongbin , Song, Xiaorong , Wu, Xiao et al. Fluorescent Enhancement of [AgS4] Microplates by Mechanical Force Induced Crystallinity Breaking [J]. | Journal of Physical Chemistry Letters , 2024 , 15 (28) : 7118-7124 . |
| MLA | Lin, Hongbin et al. "Fluorescent Enhancement of [AgS4] Microplates by Mechanical Force Induced Crystallinity Breaking" . | Journal of Physical Chemistry Letters 15 . 28 (2024) : 7118-7124 . |
| APA | Lin, Hongbin , Song, Xiaorong , Wu, Xiao , Cao, Yitao , Liu, Zhenghan , Zhang, Ruixuan et al. Fluorescent Enhancement of [AgS4] Microplates by Mechanical Force Induced Crystallinity Breaking . | Journal of Physical Chemistry Letters , 2024 , 15 (28) , 7118-7124 . |
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Currently, cisplatin resistance has been recognized as a multistep cascade process for its clinical chemotherapy failure. Hitherto, it remains challenging to develop a feasible and promising strategy to overcome the cascade drug resistance (CDR) issue for achieving fundamentally improved chemotherapeutic efficacy. Herein, a novel self-assembled nanoagent is proposed, which is constructed by Pt(IV) prodrug, cyanine dye (cypate), and gadolinium ion (Gd3+), for systematically conquering the cisplatin resistance by employing near-infrared (NIR) light activated mild-temperature hyperthermia in tumor targets. The proposed nanoagents exhibit high photostability, GSH/H+-responsive dissociation, preferable photothermal conversion, and enhanced cellular uptake performance. In particular, upon 785-nm NIR light irradiation, the generated mild temperature of approximate to 43 degrees C overtly improves the cell membrane permeability and drug uptake, accelerates the disruption of intracellular redox balance, and apparently enhances the formation of Pt-DNA adducts, thereby effectively overcoming the CDR issue and achieves highly improved therapeutic efficacy for cisplatin-resistant tumor ablation. A novel self-assembled nanoagent (Cy-Pt@HA NP) is developed to conquer the cascade drug resistance (CDR) issue of cisplatin. The proposed nanoagent presents NIR light-triggered mild hyperthermia, superior cellular uptake, and tumor-microenvironment-responsive dissociation for effective ablation of drug-resistant tumors, thereby opening a new avenue for addressing CDR issue and maximizing the platinum-based therapeutic efficacy for cancer treatment.image
Keyword ：
cascade cisplatin resistance cascade cisplatin resistance coordination self-assembly coordination self-assembly improved synergistic therapy improved synergistic therapy mild-temperature hyperthermia mild-temperature hyperthermia NIR light-responsive NIR light-responsive
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| GB/T 7714 | Chen, Mingmao , Fu, Yulei , Liu, Yan et al. NIR-Light-Triggered Mild-Temperature Hyperthermia to Overcome the Cascade Cisplatin Resistance for Improved Resistant Tumor Therapy [J]. | ADVANCED HEALTHCARE MATERIALS , 2024 , 13 (11) . |
| MLA | Chen, Mingmao et al. "NIR-Light-Triggered Mild-Temperature Hyperthermia to Overcome the Cascade Cisplatin Resistance for Improved Resistant Tumor Therapy" . | ADVANCED HEALTHCARE MATERIALS 13 . 11 (2024) . |
| APA | Chen, Mingmao , Fu, Yulei , Liu, Yan , Zhang, Baihe , Song, Xiaorong , Chen, Xinchun et al. NIR-Light-Triggered Mild-Temperature Hyperthermia to Overcome the Cascade Cisplatin Resistance for Improved Resistant Tumor Therapy . | ADVANCED HEALTHCARE MATERIALS , 2024 , 13 (11) . |
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Abstract ：
For malignant tumor phototherapy, current biomolecules-based materials face challenges such as limited tissue penetration, insufficient tumor accumulation, and overlook of the unique benefits of chirality, thus hampering their phototherapeutic efficiency. Herein, we introduce a novel near-infrared circularly polarized (NIR-CP) lightresponsive hybrid CuInSe2@ZnS (CISe@ZnS) quantum dots (QDs) hydrogel (QDs@L/D-Gel), which showcases distinctive NIR chiroptical activity, highly enhanced tumor retention, and superior photothermal/photodynamic properties. Particularly, the QDs@L-Gel exhibits a prominently improved photothermal conversion efficiency (PCE) of 43 % and elevated reactive oxygen species (ROS) upon 808-nm CP light irradiation, outperforming those of linearly polarized light directly emitted from a laser device. Moreover, a remarkably enhanced phototherapeutic efficacy (tumor inhibition rate = 83 %) can be achieved for QDs@L-Gel treated mice after 808-nm CP light treatment, without any toxic side effects. Our findings highlight the importance of supramolecular chirality in NIR-CP-mediated phototherapy, thereby paving a new avenue for more advanced and effective tumor treatment in clinical applications.
Keyword ：
CuInSe 2 CuInSe 2 Near-infrared Near-infrared Phototherapy Phototherapy Self-assembly Self-assembly Supramolecular chirality Supramolecular chirality
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| GB/T 7714 | Gao, Hang , Liu, Yan , Lian, Wei et al. Near-infrared circularly polarized light triggered phototherapy based on hybrid CuInSe2 quantum dot hydrogels [J]. | NANO TODAY , 2024 , 58 . |
| MLA | Gao, Hang et al. "Near-infrared circularly polarized light triggered phototherapy based on hybrid CuInSe2 quantum dot hydrogels" . | NANO TODAY 58 (2024) . |
| APA | Gao, Hang , Liu, Yan , Lian, Wei , Hu, Ping , Shang, Xiaoying , Chen, Mingmao et al. Near-infrared circularly polarized light triggered phototherapy based on hybrid CuInSe2 quantum dot hydrogels . | NANO TODAY , 2024 , 58 . |
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Ligand-protected metal nanoclusters (NCs) are ultrasmall particles (<3 nm) that represent the molecular state of metal materials. Owing to their molecule-like structure - particularly their atomic precision and protein-like hierarchy - metal NCs feature numerous useful molecule-like properties, including discrete energy levels, strong luminescence, intrinsic magnetism and programmable catalytic activity. In this Review, by regarding metal NCs as metallic analogues of organic molecules, we summarize methodological and mechanistic advances in their precise synthesis at the molecular and atomic levels. We first decipher cluster structure based on a protein-like hierarchical scheme and discuss synthetic strategies that realize molecular monodispersity in these clusters. We resolve formation mechanisms of metal NCs at the molecular level, aiming to establish step-by-step reaction maps reminiscent of total synthesis routes of organic molecules. We then examine approaches to customize the composition and morphology of the metal core, metal-ligand interface and ligand shell at the atom level. This Review concludes with our perspectives on the future development of atomic precision chemistry in both metal NCs and other inorganic nanomaterials.
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| GB/T 7714 | Yao, Qiaofeng , Zhu, Moshuqi , Yang, Zhucheng et al. Molecule-like synthesis of ligand-protected metal nanoclusters [J]. | NATURE REVIEWS MATERIALS , 2024 , 10 (2) : 89-108 . |
| MLA | Yao, Qiaofeng et al. "Molecule-like synthesis of ligand-protected metal nanoclusters" . | NATURE REVIEWS MATERIALS 10 . 2 (2024) : 89-108 . |
| APA | Yao, Qiaofeng , Zhu, Moshuqi , Yang, Zhucheng , Song, Xiaorong , Yuan, Xun , Zhang, Zhipu et al. Molecule-like synthesis of ligand-protected metal nanoclusters . | NATURE REVIEWS MATERIALS , 2024 , 10 (2) , 89-108 . |
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Gold nanoclusters (AuNCs) have shown great promise for in vivo imaging because of their definable structure, tunable photoluminescence (PL), and desired renal clearance. However, current understanding of the responsiveness of AuNCs to biological substances is still limited, which may hamper their biomedical applications. Herein, we explore the oxidation responsiveness of near-infrared II (NIR-II) luminescent AuNCs capped with two different ligands, which can be optimized for high-efficiency NIR-II PL imaging of mice acute kidney injury (AKI) featuring high-level peroxynitrite anions (ONOO-). We found that in the presence of ONOO-, N-acetylcysteine-capped AuNCs (NAC-AuNCs) tended to be oxidized more easily than that capped with the macromolecular mercapto-beta-cyclodextrin (CDS-AuNCs), resulting in the aggregation of NAC-AuNCs into large-sized assemblies, which was not observed in CDS-AuNCs. The oxidation-triggered morphology, composition, and NIR-II PL changes in NAC-AuNCs were then systematically studied. We finally demonstrated that NAC-AuNCs can be implemented for sensitive NIR-II PL imaging of mice AKI, facilitated by the synergetic in situ AuNC aggregation and decreased glomerular filtration rate (GFR) in the injured kidney, which outperforms the methods solely based on the decreased GFR effect. Therefore, this work highlights the critical significance of ligand engineering in AuNCs and may motivate future design of AuNCs for diverse bioimaging applications.
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| GB/T 7714 | Li, Shihua , Yang, Nangen , Ma, Qiuping et al. Tailoring Oxidation Responsiveness of Gold Nanoclusters via Ligand Engineering for Imaging Acute Kidney Injury [J]. | ANALYTICAL CHEMISTRY , 2023 , 95 (44) : 16153-16159 . |
| MLA | Li, Shihua et al. "Tailoring Oxidation Responsiveness of Gold Nanoclusters via Ligand Engineering for Imaging Acute Kidney Injury" . | ANALYTICAL CHEMISTRY 95 . 44 (2023) : 16153-16159 . |
| APA | Li, Shihua , Yang, Nangen , Ma, Qiuping , Li, Shijie , Tong, Shufen , Luo, Jiewei et al. Tailoring Oxidation Responsiveness of Gold Nanoclusters via Ligand Engineering for Imaging Acute Kidney Injury . | ANALYTICAL CHEMISTRY , 2023 , 95 (44) , 16153-16159 . |
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X-ray nanoscintillator-based photoresponsive therapy is emerging as a promising strategy to treat in vivo tumors, necessitating the development of nanoscintillators with X-ray-excited luminescence in the ultraviolet region (UV-XEL) for the photoactivation of therapeutic precursors. However, it remains a challenge to achieve high-efficiency X-ray-activated tumor therapy due to the limited UV-XEL efficacy. Herein, we developed novel Gd3+/Ce3+-codoped LiLuF4 nanoscintillators with strong UV-XEL for in vivo tumor therapy. Significantly, through optimization of host materials, dopants, and energy transfer process, the developed nanoscintillators enabled effective enhancement of UV-XEL (up to 18-fold) as compared with the traditional Ce3+-doped counterparts. As a proof-of-concept study to evaluate the in vivo therapeutic applications of the nanoscintillators, we integrated them with nitric oxide (NO) precursors for controllably generating NO upon the X-ray exposure, achieving superior in vivo antitumor effect upon X-ray-induced synergetic NO therapy and radiotherapy. Moreover, X-ray-activated NO therapy can inhibit tumor metastasis into liver to suppress tumor regrowth and prolong mice survival. This work might motivate future development of X-ray nanoscintillators for treating diseases in deep tissue.
Keyword ：
lanthanide lanthanide luminescence luminescence nanoscintillator nanoscintillator tumor therapy tumor therapy X-ray therapy X-ray therapy
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| GB/T 7714 | Yang, Kaidong , Yang, Yating , Sun, Dongquan et al. Designing highly UV-emitting lanthanide nanoscintillators for in vivo X-ray-activated tumor therapy [J]. | SCIENCE CHINA-MATERIALS , 2023 , 66 (10) : 4090-4099 . |
| MLA | Yang, Kaidong et al. "Designing highly UV-emitting lanthanide nanoscintillators for in vivo X-ray-activated tumor therapy" . | SCIENCE CHINA-MATERIALS 66 . 10 (2023) : 4090-4099 . |
| APA | Yang, Kaidong , Yang, Yating , Sun, Dongquan , Li, Shihua , Song, Xiaorong , Yang, Huanghao . Designing highly UV-emitting lanthanide nanoscintillators for in vivo X-ray-activated tumor therapy . | SCIENCE CHINA-MATERIALS , 2023 , 66 (10) , 4090-4099 . |
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