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学者姓名：宋晓荣
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Nanomaterials that engage in well-defined and tunable interactions with proteins are pivotal for the development of advanced applications. Achieving a precise molecular-level understanding of nano-bio interactions is essential for establishing these interactions. However, such an understanding remains challenging and elusive. Here, we identified stoichiometric interactions of water-soluble gold nanoparticles (Au NPs) with bovine serum albumin (BSA), unraveling their synergism in manipulating emission of nano-bio conjugates in the second near-infrared (NIR-II) regime. Using Au25(p-MBS)18 (p-MBS = para-mercaptobenzenesulfonic acid) as paradigm particles, we achieved precise binding of Au NPs to BSA with definitive molar ratios of 1:1 and 2:1, which is unambiguously evidenced by high-resolution mass spectrometry and transmission electron microscopy. Molecular dynamics simulations identified well-defined binding sites, mediated by electrostatic interactions and hydrogen bonds between the p-MBS moieties on the Au25(p-MBS)18 surface and BSA. Particularly, positively charged residues on BSA were found to be pivotal. By careful control of the molar ratio of Au25(p-MBS)18 to BSA, atomically precise [Au25(p-MBS)18] x -BSA conjugates (x = 1 or 2) could be formed. Through a comprehensive spectroscopy study, an electron transfer process and synergistic effect were manifested in the Au25(p-MBS)18-BSA conjugates, leading to drastically enhanced emission in the NIR-II window. This work offers insights into the precise engineering of nanomaterial-protein interactions and opens new avenues for the development of next-generation nano-bio conjugates for nanotheranostics.
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| GB/T 7714 | Zhang, Bihan , Matus, Maria Francisca , Yao, Qiaofeng et al. Unraveling the Stoichiometric Interactions and Synergism between Ligand-Protected Gold Nanoparticles and Proteins [J]. | JOURNAL OF THE AMERICAN CHEMICAL SOCIETY , 2025 , 147 (8) : 6404-6414 . |
| MLA | Zhang, Bihan et al. "Unraveling the Stoichiometric Interactions and Synergism between Ligand-Protected Gold Nanoparticles and Proteins" . | JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 147 . 8 (2025) : 6404-6414 . |
| APA | Zhang, Bihan , Matus, Maria Francisca , Yao, Qiaofeng , Song, Xiaorong , Wu, Zhennan , Hu, Wenping et al. Unraveling the Stoichiometric Interactions and Synergism between Ligand-Protected Gold Nanoparticles and Proteins . | JOURNAL OF THE AMERICAN CHEMICAL SOCIETY , 2025 , 147 (8) , 6404-6414 . |
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The hypoxic tumor microenvironment (TME), inadequate penetration depth of Vis/NIR light, and lack of sustaining reactive oxygen species (ROS) production capability of photosensitizers pose significant obstacles to the widespread clinic applications of photodynamic therapy (PDT). Herein, we developed a "persistent type I X-PDT" platform to simultaneously overcome these three limitations. Such a nanoplatform could generate efficient ROS (center dot OH and O2 center dot-) under X-ray irradiation in both normoxic and hypoxic environments. The ROS production persists in tumor cells for more than 4 h, even after the X-ray source is removed. Notably, the persistent type I X-PDT does not increase the levels of hypoxia-inducible factor-1 alpha (HIF-1 alpha) and vascular endothelial growth factor (VEGF) in tumor cells both in vitro and in vivo. Moreover, to further enhance the radiotherapy efficacy in hypoxic conditions, a Pt (IV) prodrug was also introduced, which can be reduced to cisplatin selectively in tumor cells, functioning not only as a chemodrug but also as a radiosensitizer.
Keyword ：
chemotherapy chemotherapy hypoxia hypoxia persistent X-PDT persistent X-PDT radiation therapy radiation therapy type I ROS type I ROS
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| GB/T 7714 | Cheng, Wei , He, Shuai , Chen, Qiushui et al. X-ray Induced Persistent Type I Photodynamic Therapy with Enhanced Hypoxia Tolerance and Chemoradiotherapy [J]. | NANO LETTERS , 2025 , 25 (11) : 4549-4559 . |
| MLA | Cheng, Wei et al. "X-ray Induced Persistent Type I Photodynamic Therapy with Enhanced Hypoxia Tolerance and Chemoradiotherapy" . | NANO LETTERS 25 . 11 (2025) : 4549-4559 . |
| APA | Cheng, Wei , He, Shuai , Chen, Qiushui , Song, Xiaorong , Lu, Chunhua , Yang, Huanghao . X-ray Induced Persistent Type I Photodynamic Therapy with Enhanced Hypoxia Tolerance and Chemoradiotherapy . | NANO LETTERS , 2025 , 25 (11) , 4549-4559 . |
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Ultrasmall gold nanoclusters (AuNCs) with photoluminescence in the second near-infrared region (NIR-II) have emerged as promising probes for in vivo biomedical applications. However, it remains a challenge to utilize NIR-II-emitting AuNCs for imaging brain glioblastoma (GBM), which is highly lethal and hard to diagnose in time. Herein, we have presented systematic investigations on the brain delivery and GBM targeting efficacies of NIR-II-emitting AuNCs protected by different ligands. We first synthesized four types of AuNCs with surface coatings of small thiolated ligands and proteins, and then studied their in vitro penetration capability into the blood-brain barrier (BBB) and in vivo GBM targeting performances. It was found that the BBB permeability of AuNCs determined by the in vitro transwell model was not evidently affected by the surface ligands. Significantly, AuNCs protected by albumin exhibited notably extended blood circulation and less skull binding compared to those protected by small ligands, enabling superior in vivo brain GBM-targeted NIR-II PL imaging. We also modified the albumin-AuNCs with targeting peptides to improve in vivo imaging contrast. Additionally, AuNCs had negligible toxic effects on major organs as well as brain tissues and neurons, corroborating their good biocompatibility. This study examined the surface engineering of NIR-II luminescent AuNCs for brain GBM targeting, which may offer insights into the future design of AuNCs for bioapplications.
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| GB/T 7714 | Tong, Shufen , Liu, Jie , Chen, Yonghui et al. Surface engineering of NIR-II luminescent gold nanoclusters for brain glioma-targeted imaging [J]. | NANOSCALE , 2025 , 17 (17) : 10670-10676 . |
| MLA | Tong, Shufen et al. "Surface engineering of NIR-II luminescent gold nanoclusters for brain glioma-targeted imaging" . | NANOSCALE 17 . 17 (2025) : 10670-10676 . |
| APA | Tong, Shufen , Liu, Jie , Chen, Yonghui , Xiao, Xinyun , Li, Shihua , Song, Xiaorong et al. Surface engineering of NIR-II luminescent gold nanoclusters for brain glioma-targeted imaging . | NANOSCALE , 2025 , 17 (17) , 10670-10676 . |
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Broadband emissive perovskites are next-generation materials for solid-state lighting and radiative detection. However, white-emitting perovskites are generally synthesized by regulating B/X sites, while not enough attention is paid to the A-site, which is thought to hardly affect the band-edge structures and optoelectronic properties. Here, a series of Sb3+-doped In-based 0D halide perovskite derivatives are described with various organoammonium cations in A-sites. Warm-white light emitting across the visible spectrum (450-850 nm), large Stokes shifts, and high photoluminescence quantum yields are easily tunable by molecularly tailoring A-site cations. These features enable a light yield up to 60976 Photons/MeV as X-ray scintillator, and a detection limit of 90 nGyair/s that is approximate to 60 times lower than the medical requirement. It is proved that A-site plays a critical role in determining the degree of distortion of polyhedra, which influences the broadband photoluminescence and self-trapped exciton (STE) dominates the emission process. Moreover, for the first time, via the incorporation of 2,6-dimethylpiperazine, a mixed A-site regulating strategy produces a standard white-light emission, which originates from the blue-light and yellow-light related to various STE emission centers. It is foreseen that this strategy highlights the expanded role of A-site and the importance of rethinking A-sites in perovskites. Efficient and tunable broadband warm-white emission is achieved by engineering the A-site organoammonium cations in Sb-doped In-based 0D perovskite derivatives, with visible light emitting, large Stokes shift, high photoluminescence yield, and X-ray scintillation. For the first time, a standard white-light emission is realized by a mixed A-site regulation strategy by the incorporation of another functional organic amine cation.image
Keyword ：
A-site A-site broadband photoluminescence broadband photoluminescence halide perovskites halide perovskites white-light emission white-light emission X-ray scintillator X-ray scintillator
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| GB/T 7714 | Huang, Hanlin , Yang, Yalin , Qiao, Shuoyan et al. Accommodative Organoammonium Cations in A-Sites of Sb―In Halide Perovskite Derivatives for Tailoring BroadBand Photoluminescence with X-Ray Scintillation and White-Light Emission [J]. | ADVANCED FUNCTIONAL MATERIALS , 2024 , 34 (8) . |
| MLA | Huang, Hanlin et al. "Accommodative Organoammonium Cations in A-Sites of Sb―In Halide Perovskite Derivatives for Tailoring BroadBand Photoluminescence with X-Ray Scintillation and White-Light Emission" . | ADVANCED FUNCTIONAL MATERIALS 34 . 8 (2024) . |
| APA | Huang, Hanlin , Yang, Yalin , Qiao, Shuoyan , Wu, Xiaodong , Chen, Zheyan , Chao, Yu et al. Accommodative Organoammonium Cations in A-Sites of Sb―In Halide Perovskite Derivatives for Tailoring BroadBand Photoluminescence with X-Ray Scintillation and White-Light Emission . | ADVANCED FUNCTIONAL MATERIALS , 2024 , 34 (8) . |
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Mechanofluorochromic materials are a type of "smart" material because of their adjustable fluorescent properties under external mechanical force, making them significant members of the materials family. However, as the fluorescent characteristics of these materials highly depend on their microstructures, the still insufficiently in-depth research linking molecular structures to light emission motivates researchers to explore the fluorescent properties of these materials under external stimuli. In this work, based on synthetic [AgS4] microplates, we explore a fascinating mechanical-induced photoluminescent enhancement phenomenon. By applying mechanical force to solid-state [AgS4] to damage the surface morphology, a significant enhancement in photoluminescence is observed. Moreover, the emitted intensity increases with the extent of damage, which can be attributed to alterations in crystallinity. This work provides valuable insights into the relationship among photoluminescence, crystallinity, and mechanical force, offering new strategies for designing luminescent devices.
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| GB/T 7714 | Lin, Hongbin , Song, Xiaorong , Wu, Xiao et al. Fluorescent Enhancement of [AgS4] Microplates by Mechanical Force Induced Crystallinity Breaking [J]. | JOURNAL OF PHYSICAL CHEMISTRY LETTERS , 2024 , 15 (28) : 7118-7124 . |
| MLA | Lin, Hongbin et al. "Fluorescent Enhancement of [AgS4] Microplates by Mechanical Force Induced Crystallinity Breaking" . | JOURNAL OF PHYSICAL CHEMISTRY LETTERS 15 . 28 (2024) : 7118-7124 . |
| APA | Lin, Hongbin , Song, Xiaorong , Wu, Xiao , Cao, Yitao , Liu, Zhenghan , Zhang, Ruixuan et al. Fluorescent Enhancement of [AgS4] Microplates by Mechanical Force Induced Crystallinity Breaking . | JOURNAL OF PHYSICAL CHEMISTRY LETTERS , 2024 , 15 (28) , 7118-7124 . |
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Metal nanoclusters (MNCs) can be synthesized with atomically precise structures and molecule formulae due to the rapid development of nanocluster science in recent decades. The ultrasmall size range (normally < 2 nm) endows MNCs with plenty of molecular-like properties, among which photoluminescent properties have aroused extensive attention. Tracing the research and development processes of luminescent nanoclusters, various photoluminescent analysis and characterization methods play a significant role in elucidating luminescent mechanism and analyzing luminescent properties. In this review, it is aimed to systematically summarize the normally used photoluminescent characterizations in MNCs including basic parameters and methods, such as excitation/emission wavelength, quantum yield, and lifetime. For each key parameter, first its definition and meaning is introduced and then the relevant characterization methods including measuring principles and the revelation of luminescent properties from the collected data are discussed. Then, it is discussed in details how to explore the luminescent mechanism of MNCs and construct NC-based applications based on the measured data. By means of these characterization strategies, the luminescent properties of MNCs and NC-based designs can be explained quantitatively and qualitatively. Hence, this review is expected to provide clear guidance for researchers to characterize luminescent MNCs and better understand the luminescent mechanism from the measured results.
Keyword ：
luminescent properties luminescent properties metal nanoclusters metal nanoclusters photoluminescence photoluminescence photoluminescent characterization photoluminescent characterization photoluminescent lifetime photoluminescent lifetime
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| GB/T 7714 | Lin, Hongbin , Song, Xiaorong , Chai, Osburg Jin Huang et al. Photoluminescent Characterization of Metal Nanoclusters: Basic Parameters, Methods, and Applications [J]. | ADVANCED MATERIALS , 2024 , 36 (25) . |
| MLA | Lin, Hongbin et al. "Photoluminescent Characterization of Metal Nanoclusters: Basic Parameters, Methods, and Applications" . | ADVANCED MATERIALS 36 . 25 (2024) . |
| APA | Lin, Hongbin , Song, Xiaorong , Chai, Osburg Jin Huang , Yao, Qiaofeng , Yang, Huanghao , Xie, Jianping . Photoluminescent Characterization of Metal Nanoclusters: Basic Parameters, Methods, and Applications . | ADVANCED MATERIALS , 2024 , 36 (25) . |
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For malignant tumor phototherapy, current biomolecules-based materials face challenges such as limited tissue penetration, insufficient tumor accumulation, and overlook of the unique benefits of chirality, thus hampering their phototherapeutic efficiency. Herein, we introduce a novel near-infrared circularly polarized (NIR-CP) lightresponsive hybrid CuInSe2@ZnS (CISe@ZnS) quantum dots (QDs) hydrogel (QDs@L/D-Gel), which showcases distinctive NIR chiroptical activity, highly enhanced tumor retention, and superior photothermal/photodynamic properties. Particularly, the QDs@L-Gel exhibits a prominently improved photothermal conversion efficiency (PCE) of 43 % and elevated reactive oxygen species (ROS) upon 808-nm CP light irradiation, outperforming those of linearly polarized light directly emitted from a laser device. Moreover, a remarkably enhanced phototherapeutic efficacy (tumor inhibition rate = 83 %) can be achieved for QDs@L-Gel treated mice after 808-nm CP light treatment, without any toxic side effects. Our findings highlight the importance of supramolecular chirality in NIR-CP-mediated phototherapy, thereby paving a new avenue for more advanced and effective tumor treatment in clinical applications.
Keyword ：
CuInSe 2 CuInSe 2 Near-infrared Near-infrared Phototherapy Phototherapy Self-assembly Self-assembly Supramolecular chirality Supramolecular chirality
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| GB/T 7714 | Gao, Hang , Liu, Yan , Lian, Wei et al. Near-infrared circularly polarized light triggered phototherapy based on hybrid CuInSe2 quantum dot hydrogels [J]. | NANO TODAY , 2024 , 58 . |
| MLA | Gao, Hang et al. "Near-infrared circularly polarized light triggered phototherapy based on hybrid CuInSe2 quantum dot hydrogels" . | NANO TODAY 58 (2024) . |
| APA | Gao, Hang , Liu, Yan , Lian, Wei , Hu, Ping , Shang, Xiaoying , Chen, Mingmao et al. Near-infrared circularly polarized light triggered phototherapy based on hybrid CuInSe2 quantum dot hydrogels . | NANO TODAY , 2024 , 58 . |
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Ligand-protected metal nanoclusters (NCs) are ultrasmall particles (<3 nm) that represent the molecular state of metal materials. Owing to their molecule-like structure - particularly their atomic precision and protein-like hierarchy - metal NCs feature numerous useful molecule-like properties, including discrete energy levels, strong luminescence, intrinsic magnetism and programmable catalytic activity. In this Review, by regarding metal NCs as metallic analogues of organic molecules, we summarize methodological and mechanistic advances in their precise synthesis at the molecular and atomic levels. We first decipher cluster structure based on a protein-like hierarchical scheme and discuss synthetic strategies that realize molecular monodispersity in these clusters. We resolve formation mechanisms of metal NCs at the molecular level, aiming to establish step-by-step reaction maps reminiscent of total synthesis routes of organic molecules. We then examine approaches to customize the composition and morphology of the metal core, metal-ligand interface and ligand shell at the atom level. This Review concludes with our perspectives on the future development of atomic precision chemistry in both metal NCs and other inorganic nanomaterials.
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| GB/T 7714 | Yao, Qiaofeng , Zhu, Moshuqi , Yang, Zhucheng et al. Molecule-like synthesis of ligand-protected metal nanoclusters [J]. | NATURE REVIEWS MATERIALS , 2024 , 10 (2) : 89-108 . |
| MLA | Yao, Qiaofeng et al. "Molecule-like synthesis of ligand-protected metal nanoclusters" . | NATURE REVIEWS MATERIALS 10 . 2 (2024) : 89-108 . |
| APA | Yao, Qiaofeng , Zhu, Moshuqi , Yang, Zhucheng , Song, Xiaorong , Yuan, Xun , Zhang, Zhipu et al. Molecule-like synthesis of ligand-protected metal nanoclusters . | NATURE REVIEWS MATERIALS , 2024 , 10 (2) , 89-108 . |
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稀土发光具有半峰宽窄、稳定性好、可见-近红外发光可调谐、寿命长等突出特点,稀土发光纳米材料已成为一类有良好应用前景的发光标记材料,在临床疾病标志物检测、活体分子影像和手术导航等领域显示了重要应用。面向肿瘤等重大疾病的精准诊断需求,主要从事稀土纳米荧光探针及其低(无)背景荧光传感与成像等领域研究工作,主要包括:(1)开发了系列新型时间分辨稀土荧光纳米探针及其生物传感新方法,以期解决复杂体系生物标志物检测中的背景干扰和灵敏度低难题,实现恶性肿瘤、器官损伤等重大疾病的高灵敏体外诊断;(2)发展了基于稀土纳米闪烁体的新型X射线发光分子成像模式,建立面向深层活体的近红外二区成像新方法,致力于克服传统光学成像穿透深度低、准确性不足问题,实现深层活体的高效分子成像。
Keyword ：
活体成像 活体成像 稀土荧光 稀土荧光 纳米探针 纳米探针 荧光传感 荧光传感
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| GB/T 7714 | 宋晓荣 . 稀土荧光标记的生物传感与成像 [C] //中国稀土学会第五届青年学术会议 . 2024 . |
| MLA | 宋晓荣 . "稀土荧光标记的生物传感与成像" 中国稀土学会第五届青年学术会议 . (2024) . |
| APA | 宋晓荣 . 稀土荧光标记的生物传感与成像 中国稀土学会第五届青年学术会议 . (2024) . |
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Gold nanoclusters (AuNCs) are emerging as promising functional probes for bioapplications. However, because of rapid renal clearance, it is a challenge to tailor their biofate and improve their disease-targeting ability in vivo. Herein, we report an efficient strategy to tailor their organotropic actions by rationally designing AuNC assemblies. The nanocluster assembly is established based on the moderate electrostatic interaction or strong coordination between AuNCs, enabled by solely chitosan (CS) or the coadded chelating metal ions (e.g., Gd3+). We show that AuNCs-CS is rapidly excreted into urine, while further coordination of Gd3+ confers assemblies with liver and lung accumulation capabilities, dependent on Gd3+ contents. The organotropic actions are unraveled to result from their tunable stability in vivo and binding capability to cells/proteins. We also demonstrate that lung-targeting assemblies can enable specific NIR-II luminescence imaging of lung orthotopic tumors, which cannot be realized by employing discrete AuNCs. We anticipate that these findings will offer insights into the design principles of metal nanocluster probes and related bioapplications.
Keyword ：
gold clusters gold clusters in vivo imaging in vivo imaging luminescence imaging luminescence imaging metal nanoclusters metal nanoclusters nanoprobe nanoprobe
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| GB/T 7714 | Song, Xiaorong , Wei, Jing , Cai, Xiyang et al. Organotropic Engineering of Luminescent Gold Nanoclusters for In Vivo Imaging of Lung Orthotopic Tumors [J]. | ACS NANO , 2024 , 18 (49) : 33555-33565 . |
| MLA | Song, Xiaorong et al. "Organotropic Engineering of Luminescent Gold Nanoclusters for In Vivo Imaging of Lung Orthotopic Tumors" . | ACS NANO 18 . 49 (2024) : 33555-33565 . |
| APA | Song, Xiaorong , Wei, Jing , Cai, Xiyang , Liu, Yizhuo , Wu, Fengbo , Tong, Shufen et al. Organotropic Engineering of Luminescent Gold Nanoclusters for In Vivo Imaging of Lung Orthotopic Tumors . | ACS NANO , 2024 , 18 (49) , 33555-33565 . |
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