A　new　tetra-a-substituted　zinc(II)　phthalocyanine　containing　dodeca-amino　groups　(compound　4)　and　its　quaternized　analogue　(compound　5)　have　been　prepared　and　evaluated　for　their　photoactivities　against　Candida　albicans.　Compared　with　the　dodeca-amino　phthalocyanine　4,　the　dodeca-cationic　phthalocyanine　5　exhibits　a　higher　photodynamic　inactivation　against　C.　albicans　with　an　IC90　value　down　to　1.46　mu　M,　which　can　be　attributed　to　its　non-aggregated　nature　in　aqueous　environments　and　more　efficient　cellular　uptake.　More　interestingly,　5　shows　a　higher　photodynamic　inactivation　on　C.　albicans　due　to　its　stronger　affinity　to　C.　albicans　cells　than　mammalian　cells.　These　results　suggest　that　the　highly　positive-charged　phthalocyanine　5　is　a　potential　non-aggregated　antifungal　photosensitizer,　which　shows　some　selectivity　toward　the　fungus.　(C)　2015　Elsevier　Ltd.　All　rights　reserved.