Highly positive-charged zinc(II) phthalocyanine as non-aggregated and efficient antifungal photosensitizer - Details

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Abstract：

Abstract　A　new　tetra-α-substituted　zinc(II)　phthalocyanine　containing　dodeca-amino　groups　(compound　4)　and　its　quaternized　analogue　(compound　5)　have　been　prepared　and　evaluated　for　their　photoactivities　against　Candida　albicans.　Compared　with　the　dodeca-amino　phthalocyanine　4,　the　dodeca-cationic　phthalocyanine　5　exhibits　a　higher　photodynamic　inactivation　against　C.　albicans　with　an　IC90　value　down　to　1.46　μM,　which　can　be　attributed　to　its　non-aggregated　nature　in　aqueous　environments　and　more　efficient　cellular　uptake.　More　interestingly,　5　shows　a　higher　photodynamic　inactivation　on　C.　albicans　due　to　its　stronger　affinity　to　C.　albicans　cells　than　mammalian　cells.　These　results　suggest　that　the　highly　positive-charged　phthalocyanine　5　is　a　potential　non-aggregated　antifungal　photosensitizer,　which　shows　some　selectivity　toward　the　fungus.　©　2015　Elsevier　Ltd.

Keyword：

Antifungal; Non-aggregated; Photodynamic inactivation; Photosensitizer; Zinc(II) phthalocyanine

Community：

[ 1 ] [Li, X.-S.]College of Chemistry, State Key Laboratory of Photocatalysis on Energy and Environment, Fuzhou University, Fuzhou, 350116, China
[ 2 ] [Guo, J.]College of Chemistry, State Key Laboratory of Photocatalysis on Energy and Environment, Fuzhou University, Fuzhou, 350116, China
[ 3 ] [Zhuang, J.-J.]College of Chemistry, State Key Laboratory of Photocatalysis on Energy and Environment, Fuzhou University, Fuzhou, 350116, China
[ 4 ] [Zheng, B.-Y.]College of Chemistry, State Key Laboratory of Photocatalysis on Energy and Environment, Fuzhou University, Fuzhou, 350116, China
[ 5 ] [Ke, M.-R.]College of Chemistry, State Key Laboratory of Photocatalysis on Energy and Environment, Fuzhou University, Fuzhou, 350116, China
[ 6 ] [Huang, J.-D.]College of Chemistry, State Key Laboratory of Photocatalysis on Energy and Environment, Fuzhou University, Fuzhou, 350116, China

Reprint 's Address：

[Huang, J.-D.]College of Chemistry, State Key Laboratory of Photocatalysis on Energy and Environment, Fuzhou UniversityChina

Email：

jdhuang@fzu.edu.cn

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Source ：

Bioorganic and Medicinal Chemistry Letters

ISSN： 0960-894X

Year： 2015

Issue： 11

Volume： 25

Page： 2386-2389

2 . 4 8 6

JCR@2015

2 . 5 0 0

JCR@2023

ESI HC Threshold：265

JCR Journal Grade：2

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ESI Highly Cited Papers on the List： 0 Unfold All

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30 Days PV： 2

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