A　series　of　zinc(II)　phthalocyanines　(ZnPcs)　mono-substituted　and　tetra-substituted　with　morpholinyl　moieties　and　their　quaternized　derivatives　have　been　synthesized　and　evaluated　for　their　antifungal　photodynamic　activities　toward　Candida　albicans.　The　alpha-substituted,　quaternized,　and　mono-substituted　ZnPcs　are　found　to　have　higher　antifungal　photoactivity　than　beta-substituted,　neutral,　and　tetra-substituted　counterparts.　The　cationic　alpha-mono-substituted　ZnPc　(6a)　exhibits　the　highest　photocytotoxicity.　Moreover,　it　is　more　potent　than　axially　di-substituted　analogue.　The　different　photocytotoxicities　of　these　compounds　have　also　been　rationalized　by　investigating　their　spectroscopic　and　photochemical　properties,　aggregation　trend,　partition　coefficients,　and　cellular　uptake.　The　IC90　value　of　6a　against　C.　albicans　cells　is　as　low　as　3.3　mu　M　with　a　light　dose　of　27　J　cm(-2),　meaning　that　6a　is　a　promising　candidate　as　the　antifungal　photosensitizer　for　future　investigations.　(C)　2016　Elsevier　Masson　SAS.　All　rights　reserved.