Home>Results

  • Complex
  • Title
  • Keyword
  • Abstract
  • Scholars
  • Journal
  • ISSN
  • Conference
成果搜索

[期刊论文]

Enhancing Antitumor Efficacy by Simultaneous ATP-Responsive Chemodrug Release and Cancer Cell Sensitization Based on a Smart Nanoagent

Share
Edit Delete 报错

author:

Song, Xiao-Rong (Song, Xiao-Rong.) [1] (Scholars:宋晓荣) | Li, Shi-Hua (Li, Shi-Hua.) [2] | Guo, Hanhan (Guo, Hanhan.) [3] | Unfold

Indexed by:

EI Scopus SCIE

Abstract:

The exploitation of smart nanoagents based drug delivery systems (DDSs) has proven to be a promising strategy for fighting cancers. Hitherto, such nanoagents still face challenges associated with their complicated synthesis, insufficient drug release in tumors, and low cancer cell chemosensitivity. Here, the engineering of an adenosine triphosphate (ATP)-activatable nanoagent is demonstrated based on self-assembled quantum dots-phenolic nanoclusters to circumvent such challenges. The smart nanoagent constructed through a one-step assembly not only has high drug loading and low cytotoxicity to normal cells, but also enables ATP-activated disassembly and controlled drug delivery in cancer cells. Particularly, the nanoagent can induce cell ATP depletion and increase cell chemosensitivity for significantly enhanced cancer chemotherapy. Systematic in vitro and in vivo studies further reveal the capabilities of the nanoagent for intracellular ATP imaging, high tumor accumulation, and eventual body clearance. As a result, the presented multifunctional smart nanoagent shows enhanced antitumor efficacy by simultaneous ATP-responsive chemodrug release and cancer cell sensitization. These findings offer new insights toward the design of smart nanoagents for improved cancer therapeutics.

Keyword:

antitumor cell sensitization chemodrugs nanoagents quantum dots

Community:

  • [ 1 ] [Song, Xiao-Rong]Chinese Acad Sci, Fujian Inst Res Struct Matter, Fujian Key Lab Nanomat, CAS Key Lab Design & Assembly Funct Nanostruct, Fuzhou 350002, Fujian, Peoples R China
  • [ 2 ] [Guo, Hanhan]Chinese Acad Sci, Fujian Inst Res Struct Matter, Fujian Key Lab Nanomat, CAS Key Lab Design & Assembly Funct Nanostruct, Fuzhou 350002, Fujian, Peoples R China
  • [ 3 ] [You, Wenwu]Chinese Acad Sci, Fujian Inst Res Struct Matter, Fujian Key Lab Nanomat, CAS Key Lab Design & Assembly Funct Nanostruct, Fuzhou 350002, Fujian, Peoples R China
  • [ 4 ] [Tu, Datao]Chinese Acad Sci, Fujian Inst Res Struct Matter, Fujian Key Lab Nanomat, CAS Key Lab Design & Assembly Funct Nanostruct, Fuzhou 350002, Fujian, Peoples R China
  • [ 5 ] [Chen, Xueyuan]Chinese Acad Sci, Fujian Inst Res Struct Matter, Fujian Key Lab Nanomat, CAS Key Lab Design & Assembly Funct Nanostruct, Fuzhou 350002, Fujian, Peoples R China
  • [ 6 ] [Song, Xiao-Rong]Fuzhou Univ, Coll Chem, MOE Key Lab Analyt Sci Food Safety & Biol, State Key Lab Photocatalysis Energy & Environm, Fuzhou 350116, Fujian, Peoples R China
  • [ 7 ] [Li, Shi-Hua]Fuzhou Univ, Coll Chem, MOE Key Lab Analyt Sci Food Safety & Biol, State Key Lab Photocatalysis Energy & Environm, Fuzhou 350116, Fujian, Peoples R China
  • [ 8 ] [Li, Juan]Fuzhou Univ, Coll Chem, MOE Key Lab Analyt Sci Food Safety & Biol, State Key Lab Photocatalysis Energy & Environm, Fuzhou 350116, Fujian, Peoples R China
  • [ 9 ] [Lu, Chun-Hua]Fuzhou Univ, Coll Chem, MOE Key Lab Analyt Sci Food Safety & Biol, State Key Lab Photocatalysis Energy & Environm, Fuzhou 350116, Fujian, Peoples R China
  • [ 10 ] [Yang, Huang-Hao]Fuzhou Univ, Coll Chem, MOE Key Lab Analyt Sci Food Safety & Biol, State Key Lab Photocatalysis Energy & Environm, Fuzhou 350116, Fujian, Peoples R China

Reprint 's Address:

  • 杨黄浩

    [Chen, Xueyuan]Chinese Acad Sci, Fujian Inst Res Struct Matter, Fujian Key Lab Nanomat, CAS Key Lab Design & Assembly Funct Nanostruct, Fuzhou 350002, Fujian, Peoples R China;;[Yang, Huang-Hao]Fuzhou Univ, Coll Chem, MOE Key Lab Analyt Sci Food Safety & Biol, State Key Lab Photocatalysis Energy & Environm, Fuzhou 350116, Fujian, Peoples R China

Show more details

Source :

ADVANCED SCIENCE

ISSN: 2198-3844

Year: 2018

Issue: 12

Volume: 5

1 5 . 8 0 4

JCR@2018

1 4 . 3 0 0

JCR@2023

ESI Discipline: PHYSICS;

ESI HC Threshold:158

JCR Journal Grade:1

CAS Journal Grade:2

Cited Count:

WoS CC Cited Count: 39

30 Days PV: 3

查看更多>>操作日志

管理员  2025-05-23 00:29:11  更新被引

管理员  2025-04-04 00:25:32  更新被引

管理员  2025-01-03 00:24:23  更新被引

管理员  2024-10-18 00:22:26  更新被引

Online/Total:54/10894489
Address:FZU Library(No.2 Xuyuan Road, Fuzhou, Fujian, PRC Post Code:350116) Contact Us:0591-22865326
Copyright:FZU Library Technical Support:Beijing Aegean Software Co., Ltd. 闽ICP备05005463号-1