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author：

Song, X.-R. (Song, X.-R..) [1] | Li, S.-H. (Li, S.-H..) [2] | Guo, H. (Guo, H..) [3] | You, W. (You, W..) [4] | Tu, D. (Tu, D..) [5] | Li, J. (Li, J..) [6] | Lu, C.-H. (Lu, C.-H..) [7] | Yang, H.-H. (Yang, H.-H..) [8] | Chen, X. (Chen, X..) [9]

Indexed by：

Scopus

Abstract：

The　exploitation　of　smart　nanoagents　based　drug　delivery　systems　(DDSs)　has　proven　to　be　a　promising　strategy　for　fighting　cancers.　Hitherto,　such　nanoagents　still　face　challenges　associated　with　their　complicated　synthesis,　insufficient　drug　release　in　tumors,　and　low　cancer　cell　chemosensitivity.　Here,　the　engineering　of　an　adenosine　triphosphate　(ATP)-activatable　nanoagent　is　demonstrated　based　on　self-assembled　quantum　dots-phenolic　nanoclusters　to　circumvent　such　challenges.　The　smart　nanoagent　constructed　through　a　one-step　assembly　not　only　has　high　drug　loading　and　low　cytotoxicity　to　normal　cells,　but　also　enables　ATP-activated　disassembly　and　controlled　drug　delivery　in　cancer　cells.　Particularly,　the　nanoagent　can　induce　cell　ATP　depletion　and　increase　cell　chemosensitivity　for　significantly　enhanced　cancer　chemotherapy.　Systematic　in　vitro　and　in　vivo　studies　further　reveal　the　capabilities　of　the　nanoagent　for　intracellular　ATP　imaging,　high　tumor　accumulation,　and　eventual　body　clearance.　As　a　result,　the　presented　multifunctional　smart　nanoagent　shows　enhanced　antitumor　efficacy　by　simultaneous　ATP-responsive　chemodrug　release　and　cancer　cell　sensitization.　These　findings　offer　new　insights　toward　the　design　of　smart　nanoagents　for　improved　cancer　therapeutics.　©　2018　The　Authors.　Published　by　WILEY-VCH　Verlag　GmbH　&　Co.　KGaA,　Weinheim

Keyword：

antitumor; cell sensitization; chemodrugs; nanoagents; quantum dots

Community：

  • [ 1 ] [Song, X.-R.]CAS Key Laboratory of Design and Assembly of Functional Nanostructures, Fujian Key Laboratory of Nanomaterials, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian 350002, China
  • [ 2 ] [Song, X.-R.]MOE Key Laboratory for Analytical Science of Food Safety and Biology, State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou, Fujian 350116, China
  • [ 3 ] [Li, S.-H.]MOE Key Laboratory for Analytical Science of Food Safety and Biology, State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou, Fujian 350116, China
  • [ 4 ] [Guo, H.]CAS Key Laboratory of Design and Assembly of Functional Nanostructures, Fujian Key Laboratory of Nanomaterials, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian 350002, China
  • [ 5 ] [You, W.]CAS Key Laboratory of Design and Assembly of Functional Nanostructures, Fujian Key Laboratory of Nanomaterials, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian 350002, China
  • [ 6 ] [Tu, D.]CAS Key Laboratory of Design and Assembly of Functional Nanostructures, Fujian Key Laboratory of Nanomaterials, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian 350002, China
  • [ 7 ] [Li, J.]MOE Key Laboratory for Analytical Science of Food Safety and Biology, State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou, Fujian 350116, China
  • [ 8 ] [Lu, C.-H.]MOE Key Laboratory for Analytical Science of Food Safety and Biology, State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou, Fujian 350116, China
  • [ 9 ] [Yang, H.-H.]MOE Key Laboratory for Analytical Science of Food Safety and Biology, State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou, Fujian 350116, China
  • [ 10 ] [Chen, X.]CAS Key Laboratory of Design and Assembly of Functional Nanostructures, Fujian Key Laboratory of Nanomaterials, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian 350002, China

Reprint 's Address：

  • [Yang, H.-H.]MOE Key Laboratory for Analytical Science of Food Safety and Biology, State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou UniversityChina

Email：


hhyang@fzu.edu.cn
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Source ：

Advanced Science

ISSN： 2198-3844

Year： 2018

Issue： 12

Volume： 5

1 5 . 8 0 4

JCR@2018

1 4 . 3 0 0

JCR@2023

ESI HC Threshold：158

JCR Journal Grade：1

CAS Journal Grade：2

Cited Count：

WoS CC Cited Count：

SCOPUS Cited Count：

ESI Highly Cited Papers on the List： 0 Unfold All

WanFang Cited Count：

Chinese Cited Count：

30 Days PV： 3

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