In-plane　sulfur　vacancies　in　the　MoS2　catalyst　exhibit　great　potential　for　low-temperature　CO2　hydrogenation　to　methanol.　However,　both　CO2　and　H2　adsorb　and　activate　at　sulfur　vacancies,　leading　to　competition　between　them.　Anchoring　atomically　dispersed　Co　atoms　over　MoS2　may　facilitate　H2　adsorption　and　activation.　Here,　a　thiourea-assisted　strategy　was　employed　to　construct　a　Co-thiourea　complex,　which　transformed　into　atomically　dispersed　Co　species　after　heat　treatment.　Under　reaction　conditions　of　5　MPa　and　220　°C,　the　0.5Co/MoS2　catalyst　achieved　a　methanol　space-time　yield　of　323　mgMeOH　gcat-1　h-1　after　induction,　with　stability　maintained　for　at　least　500　h,　compared　to　177　mgMeOH　gcat-1　h-1　for　pristine　MoS2.　Mechanistic　study　revealed　that　the　hydrogenation　of　CO2　to　methanol　follows　the　COOH*　pathway,　where　CO2　is　first　hydrogenated　to　COOH*　intermediate　and　then　gradually　hydrogenated　CH3O*　species.　This　work　presents　a　viable　strategy　for　developing　atomically　dispersed　metal-MoS2　catalysts　for　CO2　hydrogenation　to　methanol.　©　2025　American　Chemical　Society.