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author:

Zhang, Z. (Zhang, Z..) [1] | Cai, W. (Cai, W..) [2] | Ma, R. (Ma, R..) [3] | Ho, S.-H. (Ho, S.-H..) [4] | Xie, Y. (Xie, Y..) [5] | Chen, J. (Chen, J..) [6]

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Scopus

Abstract:

The versatile trophic adaptability of Chlorella sorokiniana has garnered significant attention, establishing it as a promising alga for efficient lutein production. In this study, the lutein production characteristics of C. sorokiniana FZU60 were compared under autotrophic, mixotrophic, and heterotrophic conditions. The results demonstrated that glucose supplementation promoted algal cell growth but concurrently reduced lutein content. In contrast, light induction was essential for enhancing lutein synthesis. Consequently, two-stage trophic strategies were developed to simultaneously facilitate cell growth and lutein synthesis. It was determined that optimal lutein production could be achieved by employing the heterotrophy-mixotrophy strategy in conjunction with white light at 500 μmol/m2/s during the second stage (mixotrophic stage). Furthermore, combining the heterotrophy-mixotrophy strategy with fed-batch operation further enhanced the efficacy of lutein production in FZU60. The resulting lutein productivity demonstrated a remarkable 365.1 % improvement over the heterotrophy strategy (Strategy I) and an 80.8 % increase over the mixotrophy strategy (Strategy III), when both were coupled with fed-batch operation. These findings were subsequently validated in a 5 L fermenter where FZU60 exhibited exceptional lutein content, yield, and productivity reaching 6.14 mg/g, 285.02 mg/L, and 44.95 mg/L/d, respectively. Overall, this study successfully develops an effective cultivation strategy to address the inherent conflict between cell growth and lutein synthesis in algal cells, thereby demonstrating considerable potential as an industrial pathway for efficient lutein production. © 2025 Elsevier B.V.

Keyword:

Chlorella sorokiniana Fed-batch operation Lutein Trophic mode Trophic transition

Community:

  • [ 1 ] [Zhang Z.]College of Chemical Engineering, Fuzhou University, Fuzhou, 350108, China
  • [ 2 ] [Cai W.]Technical Innovation Service Platform for High-Value and High-Quality Utilization of Marine Organism, Fuzhou University, Fuzhou, 350108, China
  • [ 3 ] [Cai W.]Fujian Engineering and Technology Research Center for Comprehensive Utilization of Marine Products Waste, Fuzhou University, Fuzhou, 350108, China
  • [ 4 ] [Cai W.]Fuzhou Industrial Technology Innovation Center for High-Value Utilization of Marine Products, Fuzhou University, Fuzhou, 350108, China
  • [ 5 ] [Ma R.]Xiamen Key Laboratory for Feed Quality Testing and Safety Evaluation, Fisheries College, Jimei University, Xiamen, 361021, China
  • [ 6 ] [Ho S.-H.]Fujian Engineering and Technology Research Center for Comprehensive Utilization of Marine Products Waste, Fuzhou University, Fuzhou, 350108, China
  • [ 7 ] [Ho S.-H.]State Key Laboratory of Urban Water Resource and Environment, School of Environment, Harbin Institute of Technology, Harbin, 150090, China
  • [ 8 ] [Xie Y.]Technical Innovation Service Platform for High-Value and High-Quality Utilization of Marine Organism, Fuzhou University, Fuzhou, 350108, China
  • [ 9 ] [Xie Y.]Fujian Engineering and Technology Research Center for Comprehensive Utilization of Marine Products Waste, Fuzhou University, Fuzhou, 350108, China
  • [ 10 ] [Xie Y.]Fuzhou Industrial Technology Innovation Center for High-Value Utilization of Marine Products, Fuzhou University, Fuzhou, 350108, China
  • [ 11 ] [Chen J.]Technical Innovation Service Platform for High-Value and High-Quality Utilization of Marine Organism, Fuzhou University, Fuzhou, 350108, China
  • [ 12 ] [Chen J.]Fujian Engineering and Technology Research Center for Comprehensive Utilization of Marine Products Waste, Fuzhou University, Fuzhou, 350108, China
  • [ 13 ] [Chen J.]Fuzhou Industrial Technology Innovation Center for High-Value Utilization of Marine Products, Fuzhou University, Fuzhou, 350108, China

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Source :

Biochemical Engineering Journal

ISSN: 1369-703X

Year: 2025

Volume: 215

3 . 7 0 0

JCR@2023

Cited Count:

WoS CC Cited Count:

SCOPUS Cited Count:

ESI Highly Cited Papers on the List: 0 Unfold All

WanFang Cited Count:

Chinese Cited Count:

30 Days PV: 0

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