Resveratrol　(Res)　is　a　natural　polyphenol　exhibiting　anti-oxidant　and　anti-inflammatory　activity.　However,　the　applications　of　Res　have　been　limited　due　to　its　low　stability　and　water　solubility.　To　enhance　the　bioaccessibility　of　Res,　unfolding　bovine　serum　albumin-modified　selenium　nanoparticles　(UBSA@SeNPs)　encapsulated　within　chitosan　(CS)-coated　Pickering　emulsions　(CS-UBSA@SeNPs-PE)　were　used　to　load　Res.　The　results　showed　that　Res-loaded　CS(0.06　%)-UBSA@SeNPs-PE　has　small　droplet　size　(16.13　μm),　high　gel　properties　and　excellent　antioxidant　properties.　During　the　simulated　digestion　process,　CS　reduced　the　release　rate　of　Res　from　Res-loaded　CS(0.06　%)-UBSA@SeNPs-PE　(42.27　%)　to　reach　a　slow　release　effect.　Importantly,　Res　could　quickly　release　from　CS-UBSA@SeNPs-PE　within　intestinal　fluid　or　in　the　presence　of　chitosanase.　In　simulated　absorption　experiments,　the　intestinal　permeability　of　Res　in　Res-loaded　CS(0.06　%)-UBSA@SeNPs-PE　were　enhanced　by　292.31　%　compare　to　Res-loaded　CS(0　%)-UBSA@SeNPs-PE.　In　pharmacokinetic　studies,　Res-loaded　CS(0.06　%)-UBSA@SeNPs-PE　had　an　area　under　the　curve　(AUC)　up　to　3467.99　±　127.43　ng*h/mL.　Furthermore,　CS　also　improved　the　mucoadhesive　nature　of　UBSA@SeNPs-PE,　resulting　in　a　gut-retention　time　of　Res-loaded　CS(0.06　%)-UBSA@SeNPs-PE　that　reached　up　to　60　h.　In　conclusion,　CS-UBSA@SeNPs-PE　can　serve　as　an　effective　oral　delivery　system　for　improving　the　bioaccessibility　of　Res.　©　2024　Elsevier　B.V.