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学者姓名：杨丽聪
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Abstract ：
Ethnopharmacological relevance: As an important component of the cell wall of Gram-negative bacteria, lipopolysaccharide (LPS) is an important inducer of inflammation in humans. Smilax china L. is known for its diverse bioactive functions, particularly its anti-inflammatory effects. Aim of the study: This study aimed to investigate the bioactive function of Smilax china L. polyphenols (SCLP) on LPS-induced inflammation. Materials and methods: Inflammation in RAW264.7 macrophages and mice were induced using LPS. The cytotoxicity of SCLP was investigated by MTT assay. Inflammatory factors were detected by ELISA and RT-PCR. The expression of NF-kappa B pathway-related proteins was analyzed by Western Blotting. Results: The results demonstrated that SCLP significantly reduced the levels of pro-inflammatory factors (TNF-alpha, IL-1(3, and IL-6) and inhibited M1 polarization of macrophages in both RAW264.7 macrophages and mice (p < 0.05). Western Blotting analysis revealed that the levels of NF-kappa B signaling pathway-associated proteins (p-p65, p-IKB, p-IKK) were significantly reduced (p < 0.05). Notably, SCLP significantly downregulated the expression of pro-apoptotic proteins, while upregulating the expression of anti-apoptotic proteins in RAW264.7 macrophages (p < 0.05). Additionally, the levels of antioxidant enzymes were enhanced in mice, suggesting a potential reduction in the inflammatory response. Conclusions: These findings indicated that SCLP might inhibit LPS-induced M1 polarization through the NF-kappa B signaling pathway, thereby reducing inflammation. Consequently, SCLP might serve as a promising bioactive substance for preventing inflammation-related injury.
Keyword ：
Inflammation Inflammation M1 polarization M1 polarization NF-kappa B NF-kappa B Signaling pathway Signaling pathway Smilax china L. polyphenols Smilax china L. polyphenols
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| GB/T 7714 | Yu, Longhui , Liu, Shanshan , Liu, Jiluan et al. Smilax china L. polyphenols inhibit LPS-induced macrophage M1 polarization to alleviate inflammation through NF-κB signaling pathway in vitro and in vivo [J]. | JOURNAL OF ETHNOPHARMACOLOGY , 2025 , 342 . |
| MLA | Yu, Longhui et al. "Smilax china L. polyphenols inhibit LPS-induced macrophage M1 polarization to alleviate inflammation through NF-κB signaling pathway in vitro and in vivo" . | JOURNAL OF ETHNOPHARMACOLOGY 342 (2025) . |
| APA | Yu, Longhui , Liu, Shanshan , Liu, Jiluan , Li, Jingen , Zhang, Wenkai , Lin, Lezhen et al. Smilax china L. polyphenols inhibit LPS-induced macrophage M1 polarization to alleviate inflammation through NF-κB signaling pathway in vitro and in vivo . | JOURNAL OF ETHNOPHARMACOLOGY , 2025 , 342 . |
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Abstract ：
The effect of digestion on nanocarriers will affect the release and pharmacological effects of bioactive compounds in delivery systems. The digestion of cellulose is limited to gut microbiota, which offers a new research strategy for targeted delivery of bioactive compounds. Herein, positively charged cellulose-like chitosan/polyvinylpyrrolidone nanofiber was prepared to improve the residence time, colon target and gut microbiota regulation activity of quercetin decorated selenium nanoparticles (QUE@SeNPs/CS/PVPNFs). Selenium nanoparticles block the degradation of quercetin and QUE@SeNPs/CS/PVPNFs only decompose when caused by chitosanase secretion from gut microbiota. In vivo imaging showed that the residence time of QUE@SeNPs/CS/ PVPNFs was longer than that of QUE@SeNPs. Thus, it significantly decreased the lipid concentrations in liver, which further inhibited insulin resistance in mice. Moreover, QUE@SeNPs/CS/PVPNFs treatment improves gut barrier integrity, increased the relative abundance of anti-obesity and anti-inflammation related bacterial including Akkermansia, Lactobacillus and Bacteroides. Consequently, the inflammatory factor (IL-beta and TNF-alpha) levels in gut, liver and brain were also decreased. Nissl and PSD-95 staining indicated that QUE@SeNPs/CS/ PVPNFs ameliorated synapse dysfunction in the brain. Therefore, QUE@SeNPs/CS/PVPNFs has a greater effect than QUE@SeNPs in improving cognitive ability in Morris water maze. Overall, QUE@SeNPs/CS/PVPNFs with prolonged residence time attenuates cognitive disorder via gut-liver-brain axis in AD.
Keyword ：
Alzheimer's disease Alzheimer's disease Chitosan Chitosan Gut-liver-brain axis Gut-liver-brain axis Obesity Obesity Quercetin modified selenium nanoparticles Quercetin modified selenium nanoparticles
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| GB/T 7714 | Fang, Chaoping , Chen, Qingchang , Zheng, Guodong et al. Cellulose-like chitosan microfibrils facilitate targeted release and enhance the prolonged residence time of quercetin-selenium nanoparticles for Alzheimer's disease treatment [J]. | INTERNATIONAL JOURNAL OF PHARMACEUTICS , 2025 , 670 . |
| MLA | Fang, Chaoping et al. "Cellulose-like chitosan microfibrils facilitate targeted release and enhance the prolonged residence time of quercetin-selenium nanoparticles for Alzheimer's disease treatment" . | INTERNATIONAL JOURNAL OF PHARMACEUTICS 670 (2025) . |
| APA | Fang, Chaoping , Chen, Qingchang , Zheng, Guodong , Zhang, Fang , Li, Zhiwei , Mei, Jingtao et al. Cellulose-like chitosan microfibrils facilitate targeted release and enhance the prolonged residence time of quercetin-selenium nanoparticles for Alzheimer's disease treatment . | INTERNATIONAL JOURNAL OF PHARMACEUTICS , 2025 , 670 . |
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Resveratrol (Res) is a natural polyphenol exhibiting anti-oxidant and anti-inflammatory activity. However, the applications of Res have been limited due to its low stability and water solubility. To enhance the bioaccessibility of Res, unfolding bovine serum albumin-modified selenium nanoparticles (UBSA@SeNPs) encapsulated within chitosan (CS)-coated Pickering emulsions (CS-UBSA@SeNPs-PE) were used to load Res. The results showed that Res-loaded CS(0.06 %)-UBSA@SeNPs-PE has small droplet size (16.13 mu m), high gel properties and excellent antioxidant properties. During the simulated digestion process, CS reduced the release rate of Res from Resloaded CS(0.06 %)-UBSA@SeNPs-PE (42.27 %) to reach a slow release effect. Importantly, Res could quickly release from CS-UBSA@SeNPs-PE within intestinal fluid or in the presence of chitosanase. In simulated absorption experiments, the intestinal permeability of Res in Res-loaded CS(0.06 %)-UBSA@SeNPs-PE were enhanced by 292.31 % compare to Res-loaded CS(0 %)-UBSA@SeNPs-PE. In pharmacokinetic studies, Resloaded CS(0.06 %)-UBSA@SeNPs-PE had an area under the curve (AUC) up to 3467.99 +/- 127.43 ng*h/mL. Furthermore, CS also improved the mucoadhesive nature of UBSA@SeNPs-PE, resulting in a gut-retention time of Res-loaded CS(0.06 %)-UBSA@SeNPs-PE that reached up to 60 h. In conclusion, CS-UBSA@SeNPs-PE can serve as an effective oral delivery system for improving the bioaccessibility of Res.
Keyword ：
Bioaccessibility Bioaccessibility Chitosan crosslinking Chitosan crosslinking Pickering emulsion Pickering emulsion Resveratrol Resveratrol Selenium nanoparticle Selenium nanoparticle
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| GB/T 7714 | Mei, Jingtao , Shi, Xianai , Chen, Mingmao et al. Unfolding bovine serum albumin decorated selenium nanoparticles crosslinking with chitosan: Achieve stabilization of Pickering emulsions gel and enhance resveratrol bioaccessibility [J]. | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES , 2024 , 289 . |
| MLA | Mei, Jingtao et al. "Unfolding bovine serum albumin decorated selenium nanoparticles crosslinking with chitosan: Achieve stabilization of Pickering emulsions gel and enhance resveratrol bioaccessibility" . | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 289 (2024) . |
| APA | Mei, Jingtao , Shi, Xianai , Chen, Mingmao , Cui, Yanan , Fang, Chaoping , Yang, Licong . Unfolding bovine serum albumin decorated selenium nanoparticles crosslinking with chitosan: Achieve stabilization of Pickering emulsions gel and enhance resveratrol bioaccessibility . | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES , 2024 , 289 . |
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The onset of Alzheimer's disease (AD) is significantly influenced by oxidative stress. Trace element selenium (Se) can be incorporated into selenoproteins to participate in redox regulation. In our previous study, it was found that brain-targeting chlorogenic acid-modified selenium nanoparticles (SeNPs) could effectively relieve oxidative stress in AD. However, the main mechanism of polyphenol-decorated SeNPs on antioxidant enzymes such as glutathione peroxidase is still unknown. Dihydromyricetin (DMY) is one polyphenol that has neuroprotective effects through antioxidant activities. In this study, chitosan (CS) was introduced as a stabilizer for the synthesis of a brain-targeted peptide (Tg: TGNYKALHPHNG) and DMY-modified SeNPs (Tg-CS/DMY@SeNPs). Tg-CS/DMY@SeNPs could improve the solubility of DMY and exhibited better free radical scavenging ability than DMY. Meanwhile, Tg-CS/DMY@SeNPs significantly enhanced the activity of antioxidant enzymes, which effectively inhibited ROS accumulation in A beta aggregate-induced PC12 cells. More importantly, Tg-CS/DMY@SeNPs could activate the Nrf2/Keap-1 signaling pathway to regulate the activity of antioxidant enzymes, especially selenophenase glutathione peroxidase in the brain and liver of APP/PS1 mice. In that case, Tg-CS/DMY@SeNPs also prevented oxidative damage-induced apoptosis by inhibiting the Caspase-3 signaling pathway in the brain and liver of APP/PS1 mice. Finally, Tg-CS/DMY@SeNPs remarkably improved cognitive disorders in the APP/PS1 mice. These results indicated that Tg-CS/DMY@SeNPs exhibited promising therapeutic effects in the antioxidant therapy of AD.
Keyword ：
Alzheimer's disease Alzheimer's disease antioxidant antioxidant dihydromyricetin dihydromyricetin selenium nanoparticles selenium nanoparticles selenoprotein selenoprotein
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| GB/T 7714 | Li, Zhiwei , Liang, Hanji , Wang, Yabin et al. Brain-Targeting Dihydromyricetin-Decorated Selenium Nanoparticles Attenuate Oxidative Stress for Treatment of Alzheimer's Disease [J]. | ACS APPLIED NANO MATERIALS , 2024 , 7 (17) : 20411-20424 . |
| MLA | Li, Zhiwei et al. "Brain-Targeting Dihydromyricetin-Decorated Selenium Nanoparticles Attenuate Oxidative Stress for Treatment of Alzheimer's Disease" . | ACS APPLIED NANO MATERIALS 7 . 17 (2024) : 20411-20424 . |
| APA | Li, Zhiwei , Liang, Hanji , Wang, Yabin , Zheng, Guodong , Yang, Licong . Brain-Targeting Dihydromyricetin-Decorated Selenium Nanoparticles Attenuate Oxidative Stress for Treatment of Alzheimer's Disease . | ACS APPLIED NANO MATERIALS , 2024 , 7 (17) , 20411-20424 . |
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The pathology of Alzheimer's disease (AD) is highly correlated with obesity-induced insulin resistance. Resveratrol (Res) is a natural phenol that demonstrates a neuroprotective effect, but the bioactivity of Res is low in vivo. Here, chitosan (CS) was cross-linked with sodium tripolyphosphate (TPP) to encapsulate low water solubility Res. Next, a brain-targeted peptide (TG: TGNYKALHPHNG) was modified on the surface of Res-loaded CS/TPP nanoparticles (TG-Res-CS/TPP-NPs) to specifically deliver Res to the brain. Morris water maze results indicated that cognitive impairments were ameliorated by TG-Res-CS/TPP-NPs in obesity-related AD mice. Obesity-related insulin resistance promotes Tau phosphorylation and A beta aggregation in the brain. Administration of TG-Res-CS/TPP-NPs alleviated lipid deposition-induced insulin resistance and decreased the level of phos-phorylated Tau and A beta aggregation via the JNK/AKT/GSK3 beta pathway. Additionally, TG-Res-CS/TPP-NPs transported across blood-brain barrier which in turn increased glucose transporter expression levels, antioxi-dant enzyme activity and inhibited microglial cell activation. Thus, TG-Res-CS/TPP-NPs were more effective than Res-CS/TPP-NPs at regulating glucose homeostasis, oxidative stress and neuroinflammation in the brain. Moreover, inflammatory, lipid metabolism and oxidative stress-related gut microbiota including Helicobacter, Colidextribacter, Anaerotruncus, Parasutterella, Allobaculum, Alloprevotella, Alistipes, Bifidobacterium and Candida-tus_Saccharimonas were also regulated by TG-Res-CS/TPP-NPs. This work indicates the potential use of TG-Res-CS/TPP-NPs for the delivery of Res.
Keyword ：
Alzheimer?s disease Alzheimer?s disease Blood brain barrier Blood brain barrier Brain delivery Brain delivery Chitosan nanoparticles Chitosan nanoparticles Gut microbiota Gut microbiota Insulin resistance Insulin resistance
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| GB/T 7714 | Yang, Licong , Wang, Yabin , Li, Zhiwei et al. Brain targeted peptide-functionalized chitosan nanoparticles for resveratrol delivery: Impact on insulin resistance and gut microbiota in obesity-related Alzheimer?s disease [J]. | CARBOHYDRATE POLYMERS , 2023 , 310 . |
| MLA | Yang, Licong et al. "Brain targeted peptide-functionalized chitosan nanoparticles for resveratrol delivery: Impact on insulin resistance and gut microbiota in obesity-related Alzheimer?s disease" . | CARBOHYDRATE POLYMERS 310 (2023) . |
| APA | Yang, Licong , Wang, Yabin , Li, Zhiwei , Wu, Xiaohua , Mei, Jingtao , Zheng, Guodong . Brain targeted peptide-functionalized chitosan nanoparticles for resveratrol delivery: Impact on insulin resistance and gut microbiota in obesity-related Alzheimer?s disease . | CARBOHYDRATE POLYMERS , 2023 , 310 . |
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Abstract ：
Resveratrol (Res) is a common natural polyphenol that inhibits inflammation and oxidative stress in Alzheimer's disease (AD). However, the absorption efficiency and in vivo bioactivity of Res are poor. High fat diet-induced metabolic disorders, including obesity and insulin resistance, can promote AD-related beta-amyloid (A beta) aggrega-tion, Tau protein phosphorylation and neurotoxicity. Gut microbiota play a role in modulating metabolic syn-drome and cognitive impairment. Herein, flower-like Res-loaded selenium nanoparticles/chitosan nanoparticles (Res@SeNPs@Res-CS-NPs) with higher loading capacity (64 %) were prepared to regulate gut microbiota in cases of AD with metabolic disorder. The nano-flowers could restore gut microbiota homeostasis to reduce lipopolysaccharide (LPS) formation and LPS-induced neuroinflammation. Additionally, Res@SeNPs@Res-CS-NPs can prevent lipid deposition and insulin resistance by decreasing Firmicutes levels and increasing Bacteroidetes levels in the gut, further inhibiting A beta aggregation and Tau protein phosphorylation through the JNK/AKT/ GSK3 beta signaling pathway. Moreover, Res@SeNPs@Res-CS-NPs treatment was able to regulate the relative levels of gut microbiota associated with oxidative stress, inflammation and lipid deposition, including Entercoccus, Colidextribacter, Rikenella, Ruminococcus, Candidatus_Saccharimonas, Alloprevotella and Lachnospiraceae_UCG-006. Overall, Res@SeNPs@Res-CS-NPs significantly enhances cognitive ability in AD mice with metabolic disorder, highlighting their potential for preventing cognitive impairments in AD.
Keyword ：
Alzheimer?s disease Alzheimer?s disease Gut microbiota Gut microbiota Resveratrol modified selenium nanoparticles Resveratrol modified selenium nanoparticles
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| GB/T 7714 | Yang, Licong , Wang, Yabin , Zheng, Guodong et al. Resveratrol-loaded selenium/chitosan nano-flowers alleviate glucolipid metabolism disorder-associated cognitive impairment in Alzheimer?s disease [J]. | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES , 2023 , 239 . |
| MLA | Yang, Licong et al. "Resveratrol-loaded selenium/chitosan nano-flowers alleviate glucolipid metabolism disorder-associated cognitive impairment in Alzheimer?s disease" . | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 239 (2023) . |
| APA | Yang, Licong , Wang, Yabin , Zheng, Guodong , Li, Zhiwei , Mei, Jingtao . Resveratrol-loaded selenium/chitosan nano-flowers alleviate glucolipid metabolism disorder-associated cognitive impairment in Alzheimer?s disease . | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES , 2023 , 239 . |
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The deposition of amyloid beta (A beta) is a conventional pathological hallmark of Alzheimer's disease (AD). Consequently, the inhibition of A beta aggregation combined with the disaggregation of A beta fibrils is an important therapeutic method for AD treatment. In this study, a gold nanoparticle-decorated porous metal organic framework MIL-101(Fe) (AuNPs@PEG@MIL-101) was created as an A beta inhibitor. The high positively charged MIL-101 induced a high number of A beta(40) to be absorbed or aggregated on the surface of nanoparticles. In addition, AuNPs improved the surface property of MIL-101, causing it to uniformly bind A beta monomers and A beta fibrils. Thus, this framework can efficiently suppress extracellular A beta monomer fibrillation and disrupt the preformed A beta fibers. AuNPs@PEG@MIL-101 also decreases intracellular A beta(40) aggregation and the amount of A beta(40) immobilized on the cell membrane, thus protecting PC12 cells from A beta(40)-induced microtubular defects and cell membrane damage. In summary, AuNPs@PEG@MIL-101 shows great potential for application in AD therapy.
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| GB/T 7714 | Yang, Licong , Chen, Yutong , Jia, Zhi et al. Electrostatic assembly of gold nanoparticle and metal-organic framework nanoparticles attenuates amyloid beta aggregate-mediated neurotoxicity [J]. | JOURNAL OF MATERIALS CHEMISTRY B , 2023 , 11 (20) : 4453-4463 . |
| MLA | Yang, Licong et al. "Electrostatic assembly of gold nanoparticle and metal-organic framework nanoparticles attenuates amyloid beta aggregate-mediated neurotoxicity" . | JOURNAL OF MATERIALS CHEMISTRY B 11 . 20 (2023) : 4453-4463 . |
| APA | Yang, Licong , Chen, Yutong , Jia, Zhi , Yuan, Xiaoyu , Liu, Jie . Electrostatic assembly of gold nanoparticle and metal-organic framework nanoparticles attenuates amyloid beta aggregate-mediated neurotoxicity . | JOURNAL OF MATERIALS CHEMISTRY B , 2023 , 11 (20) , 4453-4463 . |
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A beta aggregation-related neuroinflammation and imbalance of brain glucose homeostasis play important roles in the pathological process of Alzheimer's disease (AD). Chlorogenic acid (CGA) is one of the most common dietary polyphenols with neuroprotective effects. However, due to the low bioavailability of CGA, its application dose is usually high in vivo. In our previous study, the spherical selenium nanoparticles act as drug carriers to improve the bioactivity of resveratrol. Here, the brain-targeting peptide (TGN peptide) and CGA were used to prepare a new flowerlike selenium nanocluster (TGN-CGA@SeNCs) for enhancing the bioavailability of CGA. After decoration on selenium nanoclusters, the solubility and stability of CGA was obviously increased. Oral administration of a low dose of CGA (80 mg/kg/body weight) only slightly inhibited A beta aggregate-related neuroinflammation and glucose homeostasis disorder in the brain. Moreover, CGA showed less effect on increasing the diversity and richness of gut microbiota. At the same concentration, the CGA-modified selenium nanocluster (CGA@SeNCs) and TGN-CGA@SeNCs showed better function in ameliorating the gut microbiota disorder. Especially, TGN-CGA@SeNCs significantly increased the relative abundance of Turicibacter, Colidextribacter, Ruminococcus, Alloprevotella, and Alistipes against oxidative stress, inflammation, and glucose homeostasis imbalance. Notably, only TGN-CGA@SeNCs can transport through the blood-brain barrier (BBB), and TGN-CGA@SeNCs showed better effects than CGA@SeNCs in regulating A beta aggregation and improving brain glucose homeostasis. These results broadened the application of TGN-CGA@SeNCs, effectively improving the bioactivity of CGA, which also lowers the CGA dose for preventing AD progression.
Keyword ：
A ? aggregation A ? aggregation Alzheimer?s disease Alzheimer?s disease chlorogenic acid chlorogenic acid gut microbiota gut microbiota nanoselenium nanoselenium    
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| GB/T 7714 | Li, Zhiwei , Zheng, Guodong , Wang, Na et al. A Flower-like Brain Targeted Selenium Nanocluster Lowers the Chlorogenic Acid Dose for Ameliorating Cognitive Impairment in APP/PS1 Mice [J]. | JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY , 2023 , 71 (6) : 2883-2897 . |
| MLA | Li, Zhiwei et al. "A Flower-like Brain Targeted Selenium Nanocluster Lowers the Chlorogenic Acid Dose for Ameliorating Cognitive Impairment in APP/PS1 Mice" . | JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 71 . 6 (2023) : 2883-2897 . |
| APA | Li, Zhiwei , Zheng, Guodong , Wang, Na , Liang, Hanji , Li, Changjiang , Wang, Yabin et al. A Flower-like Brain Targeted Selenium Nanocluster Lowers the Chlorogenic Acid Dose for Ameliorating Cognitive Impairment in APP/PS1 Mice . | JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY , 2023 , 71 (6) , 2883-2897 . |
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食品中常见多酚成分及维生素C在体内外容易被氧化,性质极不稳定,影响其生物活性.前期研究中通过纳米硒(selenium nanparticles,SeNPs)负载维生素C并提高多酚类物质的生物活性,然而这些纳米硒的体内稳定性仍是未知的.该实验选取绿原酸纳米硒(CGA@SeNPs)、没食子酸纳米硒(GA@SeNPs)及维生素C纳米硒(VC@SeNPs)作为研究对象,测定不同pH下纳米硒粒径变化,胃肠液消化前后DPPH自由基和ABTS阳离子自由基清除率及表面修饰剂保留量,评估不同表面修饰纳米硒在胃肠环境中稳定性.结果表明:3种不同表面修饰纳米硒在酸性和中性条件下稳定,碱性条件下不稳定;经胃肠消化后,CGA@SeNPs结构和含量最稳定;未消化前,CGA@SeNPs对DPPH自由基和ABTS阳离子自由基抗氧化活性最好;经胃消化后,CGA@SeNPs对DPPH自由基抗氧化活性最好,VC@SeNPs对ABTS阳离子自由基抗氧化活性最好;经肠消化后GA@SeNPs对DPPH自由基抗氧化活性最好,CGA@SeNPs对ABTS阳离子自由基抗氧化活性最好.综上,CGA@SeNPs在胃肠道消化中稳定性和抗氧化活性最好.
Keyword ：
不同表面修饰纳米硒 不同表面修饰纳米硒 抗氧化活性 抗氧化活性 稳定性 稳定性 胃肠道消化 胃肠道消化
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| GB/T 7714 | 王亚彬 , 黎志伟 , 李长江 et al. 不同表面修饰纳米硒在模拟胃肠消化中稳定性及抗氧化活性变化 [J]. | 食品与发酵工业 , 2023 , 49 (1) : 53-59 . |
| MLA | 王亚彬 et al. "不同表面修饰纳米硒在模拟胃肠消化中稳定性及抗氧化活性变化" . | 食品与发酵工业 49 . 1 (2023) : 53-59 . |
| APA | 王亚彬 , 黎志伟 , 李长江 , 戴雅琪 , 何芬芳 , 郑国栋 et al. 不同表面修饰纳米硒在模拟胃肠消化中稳定性及抗氧化活性变化 . | 食品与发酵工业 , 2023 , 49 (1) , 53-59 . |
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Neuroinflammation plays a critical role in Alzheimer's disease (AD). However, it is still unknown if neuroinflammation can be effectively treated using selenium nanoparticles (SeNPs) with different surface modifications. In this study, SeNPs were coated with dihydromyricetin (DMY), a natural polyphenol, to obtain DMY@SeNPs. Given that DMY@SeNPs are unstable under physiological conditions, they were decorated step-by-step with chitosan (CS/DMY@SeNPs) and with the blood brain barrier (BBB) targeting peptide Tg (TGNYKALHPHNG) to yield Tg-CS/ DMY@SeNPs, which significantly reduced the aggregation of A beta and improved the anti-inflammatory effects of SeNPs in vitro. The mechanisms of CS/DMY@SeNPs and Tg-CS/DMY@SeNPs on regulating neuroinflammation are different. Only Tg-CS/DMY@SeNPs can cross the BBB; therefore, Tg-CS/DMY@SeNPs more successfully inhibited A beta aggregation and reduced inflammatory cytokine secretion via the NF-kappa B pathway in the brain of APP/PS1 mice compared to CS/DMY@SeNPs. Furthermore, both types of nanoparticles, however, were able to repair the gut barrier and regulate the population of inflammatory-related gut microbiota such as Bifidobacterium, Dubosiella, and Desulfovibrio. Of note, the relative abundance of Gordonibacter was only enhanced by Tg-CS/DMY@SeNPs, thereby downregulating the protein expression of the NLRP3 inflammasome and the concentrations of serum inflammatory factors. This demonstrates that Tg-CS/DMY@SeNPs ameliorate neuroinflammation through the gut microbiota-NLRP3 inflammasome-brain axis. Overall, our data suggest that Tg-CS/DMY@SeNPs are an ideal drug candidate for AD treatment.
Keyword ：
Alzheimer's disease Alzheimer's disease gut microbiota gut microbiota NLRP3 inflammasome NLRP3 inflammasome selenium nanoparticles selenium nanoparticles surface modifications surface modifications
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| GB/T 7714 | Yang, Licong , Cui, Yanan , Liang, Hanji et al. Multifunctional Selenium Nanoparticles with Different Surface Modifications Ameliorate Neuroinflammation through the Gut Microbiota-NLRP3 Inflammasome-Brain Axis in APP/PS1 Mice [J]. | ACS APPLIED MATERIALS & INTERFACES , 2022 . |
| MLA | Yang, Licong et al. "Multifunctional Selenium Nanoparticles with Different Surface Modifications Ameliorate Neuroinflammation through the Gut Microbiota-NLRP3 Inflammasome-Brain Axis in APP/PS1 Mice" . | ACS APPLIED MATERIALS & INTERFACES (2022) . |
| APA | Yang, Licong , Cui, Yanan , Liang, Hanji , Li, Zhiwei , Wang, Na , Wang, Yabin et al. Multifunctional Selenium Nanoparticles with Different Surface Modifications Ameliorate Neuroinflammation through the Gut Microbiota-NLRP3 Inflammasome-Brain Axis in APP/PS1 Mice . | ACS APPLIED MATERIALS & INTERFACES , 2022 . |
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