Flexible　sensors　have　recently　garnered　extensive　public　attention　owing　to　their　flexibility,　wearability,　and　tunable　mechanical　properties,　enabling　real-time,　non-invasive　detection　of　various　stimulations.　Sensing　materials　are　crucial　for　flexible　sensors.　To　better　enhance　the　performance,　flexible　sensors　need　to　be　integrated　with　multiple　functional　sensing　materials　to　fulfill　different　detection　demands.　Herein,　this　paper　reviews　the　latest　advancements　in　sensing　material　and　detection　modes　for　flexible　sensor　applications.　This　review　begins　with　an　introduction　to　the　development　of　different　types　of　sensing　materials.　Then,　it　comprehensively　summarizes　different　detection　modes　of　flexible　sensors.　Furthermore,　flexible　sensors　for　various　applications　based　on　these　advanced　sensing　materials　and　detection　modes　are　concluded　as　well.　The　challenges　of　flexible　sensors　in　practical　application　and　promising　solutions　are　finally　presented.　By　summarizing　recent　advances　in　flexible　sensing　technology,　this　review　intends　to　emphasize　the　potential　of　flexible　sensors　and　stimulate　innovation　in　this　field.