Gastric　ulcers　accompanied　by　acute　or　chronic　bleeding　represent　a　significant　risk　of　fatality.　However,　the　development　of　effective　strategies　for　achieving　rapid　hemostasis　and　wound　healing　in　gastric　ulcer　bleeding　represents　a　formidable　challenge.　To　address　this　challenge,　thrombin-derived　C-terminal　peptide　(TCP-25)　is　employed　as　a　targeted　agent,　and　it　is　incorporated　into　two　novel　injectable　and　biocompatible　carboxymethyl　chitosan　(CMCs)　hydrogels　via　Schiff＇s　base　reaction.　The　TCP-25　peptide　hydrogels　display　optimal　adaptability　within　the　distinctive　gastrointestinal　microenvironment,　demonstrating　a　balance　of　acid　resistance　and　degradation,　along　with　controlled　release　and　bioactivity,　and　good　bio-adhesive　properties.　Both　in　vitro　and　in　vivo　reveal　that　the　hydrogel　achieves　rapid　hemostasis.　In　an　ethanol-induced　gastric　ulcer　model　in　rats,　it　demonstrates　that　the　hydrogel　effectively　inhibits　gastric　ulcer　bleeding　by　92%　within　24-h,　exhibiting　efficacy　that　surpasses　that　of　omeprazole　medicine,　a　commonly　used　clinical　treatment.　This　enhanced　performance　is　attributed　to　the　synergistic　effects　of　the　CMCs　hydrogel　and　TCP-25　peptide　in　effectively　achieving　hemostasis,　inhibiting　bacterial　growth,　and　promoting　gastric　wound　healing　in　acute　or　chronic　bleeding　gastric　ulcers.　Consequently,　the　present　work　offers　promising　clinical　applications　for　rapid　hemostasis　and　wound　healing　in　gastric　ulcers.　Bio-inspired　self-healing　hydrogel　demonstrates　rapid　hemostasis　and　superior　gastric　ulcer　hemostasis　and　wound　healing　in　a　rat　model　in　vivo,　exhibiting　efficacy　that　surpasses　that　of　omeprazole　medicine,　a　commonly　used　clinical　treatment.　image