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author:

Wang, Yifan (Wang, Yifan.) [1] | Zhang, Chuyue (Zhang, Chuyue.) [2] | Cheng, Junyao (Cheng, Junyao.) [3] | Yan, Taoxu (Yan, Taoxu.) [4] | He, Qing (He, Qing.) [5] | Huang, Da (Huang, Da.) [6] (Scholars:黄达) | Liu, Jianheng (Liu, Jianheng.) [7] | Wang, Zheng (Wang, Zheng.) [8]

Indexed by:

Scopus SCIE

Abstract:

Intervertebral disc degeneration (IVDD) stands as the foremost contributor to low back pain (LBP), imposing a substantial weight on the world economy. Traditional treatment modalities encompass both conservative approaches and surgical interventions; however, the former falls short in halting IVDD progression, while the latter carries inherent risks. Hence, the quest for an efficacious method to reverse IVDD onset is paramount. Biomaterial delivery systems, exemplified by hydrogels, microspheres, and microneedles, renowned for their exceptional biocompatibility, biodegradability, biological efficacy, and mechanical attributes, have found widespread application in bone, cartilage, and various tissue engineering endeavors. Consequently, IVD tissue engineering has emerged as a burgeoning field of interest. This paper succinctly introduces the intervertebral disc (IVD) structure and the pathophysiology of IVDD, meticulously classifies biomaterials for IVD repair, and reviews recent advances in the field. Particularly, the strengths and weaknesses of biomaterials in IVD tissue engineering are emphasized, and potential avenues for future research are suggested.

Keyword:

biomaterials intervertebral disc intervertebral disc degeneration tissue engineering

Community:

  • [ 1 ] [Wang, Yifan]Chinese Peoples Liberat Army Gen Hosp, Dept Orthoped, Beijing 100853, Peoples R China
  • [ 2 ] [Zhang, Chuyue]Chinese Peoples Liberat Army Gen Hosp, Dept Orthoped, Beijing 100853, Peoples R China
  • [ 3 ] [Cheng, Junyao]Chinese Peoples Liberat Army Gen Hosp, Dept Orthoped, Beijing 100853, Peoples R China
  • [ 4 ] [Yan, Taoxu]Chinese Peoples Liberat Army Gen Hosp, Dept Orthoped, Beijing 100853, Peoples R China
  • [ 5 ] [Liu, Jianheng]Chinese Peoples Liberat Army Gen Hosp, Dept Orthoped, Beijing 100853, Peoples R China
  • [ 6 ] [Wang, Zheng]Chinese Peoples Liberat Army Gen Hosp, Dept Orthoped, Beijing 100853, Peoples R China
  • [ 7 ] [He, Qing]Fuzhou Univ, Coll Biol Sci & Technol, Fuzhou 350108, Peoples R China
  • [ 8 ] [Huang, Da]Fuzhou Univ, Coll Biol Sci & Technol, Fuzhou 350108, Peoples R China

Reprint 's Address:

  • [Liu, Jianheng]Chinese Peoples Liberat Army Gen Hosp, Dept Orthoped, Beijing 100853, Peoples R China;;[Wang, Zheng]Chinese Peoples Liberat Army Gen Hosp, Dept Orthoped, Beijing 100853, Peoples R China;;

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Source :

PHARMACEUTICS

Year: 2024

Issue: 8

Volume: 16

4 . 9 0 0

JCR@2023

Cited Count:

WoS CC Cited Count: 1

SCOPUS Cited Count:

ESI Highly Cited Papers on the List: 0 Unfold All

WanFang Cited Count:

Chinese Cited Count:

30 Days PV: 3

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