Most　high-grade　U　ores　are　mined　from　quartz　veins　hosted　in　granites.　The　veins　formed　at　shallow　depths　during　episodic　hydrothermal　activity,　however,　the　evolution　of　multiple　stage　fluids　is　not　well　constrained.　In　this　study,　we　collected　56　quartz　samples　from　the　world-class,　granite-related,　Zhuguangshan　U　district　(＞17,000　t　U　from　seven　deposits)　in　southern　China.　Their　textures　and　compositions　were　analyzed　using　scanning　electron　microscope　cathodoluminescence　(SEM-CL,　n　=　98)　and　laser　ablation-induction　coupled　plasma-mass　spectrometry　(LA–ICP–MS,　n　=　643).　Four　types　of　quartz　were　identified,　including　magmatic　quartz,　early　hydrothermal　euhedral　quartz,　ore　stage　hydrothermal　quartz　(U-rich),　and　late　hydrothermal　quartz.　New　quartz　textures　and　chemical　compositions　show　that　the　transition　of　early　hydrothermal　quartz　from　the　magmatic　to　hydrothermal　stages　is　discontinuous,　unlike　the　continuous　trend　observed　in　most　magmatic-hydrothermal　systems.　Ore　stage　quartz　is　CL　dark　(with　a　peak　at　650　nm),　occurs　as　rims　on　early　barren　quartz,　and　has　high　contents　of　Mn,　Al,　and　Sb.　Altered　textures　of　magmatic　quartz　developed　through　fluid-rock　reactions　at　low　temperatures,　while　rimmed　textures　of　hydrothermal　quartz　formed　during　subsequent　late-stage　U-bearing　fluid　events,　which　played　a　crucial　role　in　U　mineralization.　Quartz　in　the　Zhuguangshan　U　district　has　distinct　features　compared　to　other　magmatic-hydrothermal　systems　that　can　guide　exploration　for　high-grade　ore　in　this,　and　perhaps　other,　granite-related　U　systems.　©　2024　The　Author(s)