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author:

Xie, Wen (Xie, Wen.) [1] | Chen, Canrong (Chen, Canrong.) [2] | Li, Heming (Li, Heming.) [3] | Tu, Yuxin (Tu, Yuxin.) [4] | Zhong, Yanhui (Zhong, Yanhui.) [5] (Scholars:钟燕辉) | Lin, Zian (Lin, Zian.) [6] (Scholars:林子俺) | Cai, Zongwei (Cai, Zongwei.) [7]

Indexed by:

EI Scopus SCIE

Abstract:

Significant impairment of pulmonary function has been demonstrated through long-term exposure to neonicotinoid insecticides, such as imidacloprid (IMI). However, the underlying mechanisms of lung injury induced by IMI remain unclear. In this study, a mouse model of IMI-induced pulmonary injury was established, and the toxicity and lung damage were assessed through mouse body weight, organ index, hematological parameters, and histopathological analysis of lung tissues. Furthermore, metabolomics and transcriptomics techniques were employed to explore the mechanistic aspects. Results from the toxicity assessments indicated that mouse body weight was significantly reduced by IMI, organ index was disturbed, and hematological parameters were disrupted, resulting in pulmonary injury. The mechanistic experimental results indicate that the differences in metabolites and gene expression in mouse lungs could be altered by IMI. Validation of the results through combined analysis of metabolomics and transcriptomics revealed that the mechanism by which IMI induces lung injury in mice might be associated with the activation of the TLR4 receptor, thereby activating the PI3K/AKT/ NF- kappa B signaling pathway to induce inflammation in mouse lungs. This study provided valuable insights into the mechanisms underlying IMI-induced pulmonary damage, potentially contributing to the development of safer pest control strategies. The knowledge gained served as a robust scientific foundation for the prevention and treatment of IMI-related pulmonary injuries.

Keyword:

Imidacloprid Lung injury Metabolomics Multi-omics integrated analysis Transcriptomics

Community:

  • [ 1 ] [Xie, Wen]Fuzhou Univ, Coll Chem, Fujian Prov Key Lab Anal & Detect Technol Food Saf, Minist Educ,Key Lab Analyt Sci Food Safety & Biol, Fuzhou 350108, Fujian, Peoples R China
  • [ 2 ] [Chen, Canrong]Fuzhou Univ, Coll Chem, Fujian Prov Key Lab Anal & Detect Technol Food Saf, Minist Educ,Key Lab Analyt Sci Food Safety & Biol, Fuzhou 350108, Fujian, Peoples R China
  • [ 3 ] [Li, Heming]Fuzhou Univ, Coll Chem, Fujian Prov Key Lab Anal & Detect Technol Food Saf, Minist Educ,Key Lab Analyt Sci Food Safety & Biol, Fuzhou 350108, Fujian, Peoples R China
  • [ 4 ] [Tu, Yuxin]Fuzhou Univ, Coll Chem, Fujian Prov Key Lab Anal & Detect Technol Food Saf, Minist Educ,Key Lab Analyt Sci Food Safety & Biol, Fuzhou 350108, Fujian, Peoples R China
  • [ 5 ] [Zhong, Yanhui]Fuzhou Univ, Coll Chem, Fujian Prov Key Lab Anal & Detect Technol Food Saf, Minist Educ,Key Lab Analyt Sci Food Safety & Biol, Fuzhou 350108, Fujian, Peoples R China
  • [ 6 ] [Lin, Zian]Fuzhou Univ, Coll Chem, Fujian Prov Key Lab Anal & Detect Technol Food Saf, Minist Educ,Key Lab Analyt Sci Food Safety & Biol, Fuzhou 350108, Fujian, Peoples R China
  • [ 7 ] [Cai, Zongwei]Hong Kong Baptist Univ, Dept Chem, State Key Lab Environm & Biol Anal, Kowloon Tong, 224 Waterloo Rd, Hong Kong 999077, Peoples R China
  • [ 8 ] [Lin, Zian]Fuzhou Univ, Coll Chem, Fuzhou 350108, Fujian, Peoples R China
  • [ 9 ] [Cai, Zongwei]Fuzhou Univ, Coll Chem, Fuzhou 350108, Fujian, Peoples R China

Reprint 's Address:

  • [Lin, Zian]Fuzhou Univ, Coll Chem, Fuzhou 350108, Fujian, Peoples R China;;[Cai, Zongwei]Fuzhou Univ, Coll Chem, Fuzhou 350108, Fujian, Peoples R China;;

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Source :

SCIENCE OF THE TOTAL ENVIRONMENT

ISSN: 0048-9697

Year: 2024

Volume: 931

8 . 2 0 0

JCR@2023

Cited Count:

WoS CC Cited Count: 3

SCOPUS Cited Count: 3

ESI Highly Cited Papers on the List: 0 Unfold All

WanFang Cited Count:

Chinese Cited Count:

30 Days PV: 3

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