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学者姓名:林子俺
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Benzophenone derivatives (BPs), as synthetic chemicals widely used in personal care products, have drawn increasing attention due to their potential health risks. However, monitoring BPs in biological samples remains challenging due to their complex matrices and the deficiency in sensitivity and selectivity in current methods. Herein, a method combining hierarchically flower-like hollow covalent organic frameworks (HFH-COFs) with high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) was established for the enrichment and detection of BPs in serum samples. The HFH-COFs were synthesized at room temperature and employed as an adsorbent due to their advantageous properties. The as-prepared HFH-COFs exhibited high specific surface area (2286.53 m(2)/g), excellent chemical stability, and good thermal stability, making them ideal for efficient enrichment applications. Under optimized experimental conditions, five BPs were effectively enriched and quantified by HPLC-MS/MS in the range of 50.0-5000.0 ng/L with good linearity (r > 0.9992). The limit of detections was 0.5-10.0 ng/L. Furthermore, HFH-COFs showed high enrichment factors even over multiple adsorption-desorption cycles. This study proposed a reliable and efficient method for monitoring endocrine-disrupting compounds in complex biological samples and highlighted the potential of HFH-COFs as a superior adsorbent material for BP.
Keyword :
Benzophenone derivatives Benzophenone derivatives Hollow flower-like covalent organic frame works Hollow flower-like covalent organic frame works Mouse serum Mouse serum
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GB/T 7714 | Yang, Ziyi , Yu, Qing , Wu, Yijing et al. Facile synthesis of hierarchically flower-like hollow covalent organic frameworks for enrichment and metabolic analysis of benzophenone derivatives in mouse serum [J]. | JOURNAL OF CHROMATOGRAPHY A , 2025 , 1743 . |
MLA | Yang, Ziyi et al. "Facile synthesis of hierarchically flower-like hollow covalent organic frameworks for enrichment and metabolic analysis of benzophenone derivatives in mouse serum" . | JOURNAL OF CHROMATOGRAPHY A 1743 (2025) . |
APA | Yang, Ziyi , Yu, Qing , Wu, Yijing , Yuan, Jiahao , Dong, Shaofeng , Li, Songtao et al. Facile synthesis of hierarchically flower-like hollow covalent organic frameworks for enrichment and metabolic analysis of benzophenone derivatives in mouse serum . | JOURNAL OF CHROMATOGRAPHY A , 2025 , 1743 . |
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Matrix-assisted laser desorption/ionization (MALDI) mass spectrometry (MS) holds great promise for the rapid and sensitive detection of biomolecules, but its precise detection of small molecule metabolites is hindered by severe background interference from the organic matrix in the low molecular weight range. To address this issue, nanomaterials have commonly been utilized as substrates in LDI-MS. Among them, covalent organic frameworks (COFs), known for their unique optical absorption and structural properties, have garnered significant attention. Despite these advantages, their low ionization efficiency remains a challenge. Herein, a composite material of COF-S@Au nanoparticles (NPs), by incorporating Au NPs into a sulfur-functionalized COF (COF-S) through postsynthetic modification, was designed and adopted as substrates. This hybrid material leverages the synergistic effects of COF-S and Au NPs to improve the desorption/ionization efficiency and minimize background interference. The COF-S@Au NPs demonstrated a 5-16-fold improvement in MS signals of small biomolecules along with a clean background and excellent resistance to salt and protein interference. Their corresponding limits of detection (LODs) were achieved at similar to pmol. Furthermore, the COF-S@Au NPs were applied to analyze metabolites in a triclosan (TCS)-exposed mouse model, successfully identifying 10 differential metabolites associated with TCS toxicity. This work provides a foundation for developing advanced LDI-MS materials for high-performance metabolic analysis and offers valuable insights into TCS metabolic toxicity with potential applications in environmental toxicology.
Keyword :
gold-modified covalent organic frameworks gold-modified covalent organic frameworks LDI-MS LDI-MS metabolic analysis metabolic analysis smallmolecule smallmolecule triclosan exposure triclosan exposure
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GB/T 7714 | Jin, Yingxue , Chen, Jiajing , Xie, Wen et al. Gold-Modified Covalent Organic Frameworks-Assisted Laser Desorption/Ionization Mass Spectrometry for Analysis of Metabolites Induced by Triclosan Exposure [J]. | ACS APPLIED MATERIALS & INTERFACES , 2025 , 17 (4) : 7056-7065 . |
MLA | Jin, Yingxue et al. "Gold-Modified Covalent Organic Frameworks-Assisted Laser Desorption/Ionization Mass Spectrometry for Analysis of Metabolites Induced by Triclosan Exposure" . | ACS APPLIED MATERIALS & INTERFACES 17 . 4 (2025) : 7056-7065 . |
APA | Jin, Yingxue , Chen, Jiajing , Xie, Wen , Zhang, Jinni , Yan, Jingjing , Chen, Canrong et al. Gold-Modified Covalent Organic Frameworks-Assisted Laser Desorption/Ionization Mass Spectrometry for Analysis of Metabolites Induced by Triclosan Exposure . | ACS APPLIED MATERIALS & INTERFACES , 2025 , 17 (4) , 7056-7065 . |
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Bile acids, a representative diagnostic indicator of liver function, are used to visualize the extent of liver injury. Numerous studies have shown that triclosan (TCS) exposure leads to abnormal bile acid metabolism. As a result, there is a requirement to develop a fast and smart means to quantitatively monitor abnormal bile acids from exposure to triclosan in bio-sample. In this work, solid-phase microextraction (SPME) probes of sea urchin-like covalent organic frameworks (COF) were in situ synthesized on steel needles by using 1,3,5-tris(4-aminophenyl) benzene (TAPB) and 2,5-dimethoxybenzene-1,4-dicarboxaldehyde (DMTP) as two organic units and employed for extraction of bile acids. This TAPB-DMTP-COF-SPME possessed an excellent specified surface area (3351 m(2) g(-1)) and a high regular porosity (similar to 3.6 nm), which was an ideal adsorbent to concentrate bile acids efficiently. The created probe, together with electrospray ionization mass spectrometry (ESI/MS), proved to be a fast and specific assay for the detection of bile acids in bio-samples. The proposed method had a low limitation of detection (0.03 mu g L-1), good linearity (R-2 >= 0.9931), wide linear range (0.10-1000.00 mu g L-1) and excellent enrichment factor (63.60-252.00). Based on these excellent properties, it was successful application for the analyzing of bile acids in mice liver and feces, demonstrating the great potential of TAPB-DMTP-COF-SPME-ESI/MS in bile acids detection and liver injury diagnosis.
Keyword :
Bile acids Bile acids Covalent organic frameworks Covalent organic frameworks Electrospray ionization mass spectrometry Electrospray ionization mass spectrometry Solid-phase microextraction Solid-phase microextraction Triclosan exposure Triclosan exposure
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GB/T 7714 | Shi, Xinye , Xue, Yuandi , Tu, Yuxin et al. Covalent organic framework-based solid phase microextraction coupled with electrospray ionization mass spectrometry for the quantitative assessment of abnormal bile acids by triclosan exposure in mice [J]. | TALANTA , 2025 , 285 . |
MLA | Shi, Xinye et al. "Covalent organic framework-based solid phase microextraction coupled with electrospray ionization mass spectrometry for the quantitative assessment of abnormal bile acids by triclosan exposure in mice" . | TALANTA 285 (2025) . |
APA | Shi, Xinye , Xue, Yuandi , Tu, Yuxin , Chen, Canrong , Zhang, Yajing , Lin, Zian et al. Covalent organic framework-based solid phase microextraction coupled with electrospray ionization mass spectrometry for the quantitative assessment of abnormal bile acids by triclosan exposure in mice . | TALANTA , 2025 , 285 . |
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Surface-assisted laser desorption/ionization mass spectrometry (SALDI-MS) has been regarded as one of the prominent techniques in small molecule analysis, which employs nanostructured materials as substrates to replace conventional organic matrices for laser absorption and analyte desorption/ionization. The rational design and development of nanostructured substrates, particularly metal-organic frameworks (MOFs) and covalent-organic frameworks (COFs), are crucial for enhancing SALDI-MS performance. This review aims to cover the latest developments (within 5 years) in nanostructured substrates in SALDI-MS, including carbon- and silicon-based materials, metals and their oxide materials, MOFs, COFs, and other materials. The key design parameters that affect the SALDI-MS efficiency of these nanomaterials in small molecule analysis, such as pore size, surface area, and functional groups, are also discussed. Furthermore, the applications of SALDI-MS in various fields are reviewed. Lastly, the challenges and prospects for future research on the design of nano- structured substrates for SALDI-MS in small molecule analysis are discussed.
Keyword :
Applications Applications mass spectrometry mass spectrometry Nanomaterials Nanomaterials Small molecule Small molecule Surface-assisted laser desorption/ionization Surface-assisted laser desorption/ionization
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GB/T 7714 | Jin, Yingxue , Yan, Jingjing , Cai, Zongwei et al. Advances in nanomaterials for surface-assisted laser desorption ionization mass spectrometry: Applications in small molecule analysis over the past five years [J]. | TRAC-TRENDS IN ANALYTICAL CHEMISTRY , 2025 , 183 . |
MLA | Jin, Yingxue et al. "Advances in nanomaterials for surface-assisted laser desorption ionization mass spectrometry: Applications in small molecule analysis over the past five years" . | TRAC-TRENDS IN ANALYTICAL CHEMISTRY 183 (2025) . |
APA | Jin, Yingxue , Yan, Jingjing , Cai, Zongwei , Lin, Zian . Advances in nanomaterials for surface-assisted laser desorption ionization mass spectrometry: Applications in small molecule analysis over the past five years . | TRAC-TRENDS IN ANALYTICAL CHEMISTRY , 2025 , 183 . |
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RationalPeople are widely exposed to parabens in their daily life, but parabens are endocrine disrupting chemicals that pose a threat to human health. Therefore, establishing a rapid screening method to enhance monitoring of parabens is necessary. Herein, a covalent organic framework (COF) nanofilm-assisted laser desorption ionization mass spectrometry (LDI-MS) method was established to screen parabens in personal care products (PCPs).MethodsTAPB-TFPB-COF nanofilm was synthesized on indium tin oxide (ITO) glass and used as LDI-MS substrates. To observe the practicability of TAPB-TFPB-COF nanofilm-assisted LDI-MS, the results of this method for analyzing small molecules such as parabens, estrogens, and bisphenols were compared with those of the conventional organic matrix 9-aminoacridine (9-AA), and the reproducibility and detection limit were further verified. Finally, the method was applied to screen parabens in PCPs.ResultsTAPB-TFPB-COF nanofilm-assisted LDI-MS analyzed small molecules such as parabens, estrogens, and bisphenols with higher mass spectral signals and cleaner mass spectral backgrounds compared with 9-AA. Meanwhile, the method analyzed methylparaben (MeP) with high reproducibility (RSD = 6.96%) and low detection limit (1.64 mu M) and performed well for rapid screening of parabens in PCPs.ConclusionTAPB-TFPB-COF nanofilm-assisted LDI-MS for analyzing small molecules such as parabens, estrogens, and amino acids offered the advantages of rapid analysis, a clean background, and good reproducibility. The method was successfully applied to detecting parabens in PCPs, demonstrating the practical utility of LDI-MS based on TAPB-TFPB-COF nanofilm for analyzing parabens in complex samples.
Keyword :
covalent organic framework nanofilms covalent organic framework nanofilms endocrine disrupting chemicals endocrine disrupting chemicals laser desorption ionization mass spectrometry laser desorption ionization mass spectrometry parabens parabens personal care products personal care products
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GB/T 7714 | Zheng, Wenjun , Yan, Jingjing , Jin, Yingxue et al. Covalent Organic Framework Nanofilm-Assisted Laser Desorption Ionization Mass Spectrometry for Rapid Screening of Parabens in Personal Care Products [J]. | RAPID COMMUNICATIONS IN MASS SPECTROMETRY , 2025 , 39 (7) . |
MLA | Zheng, Wenjun et al. "Covalent Organic Framework Nanofilm-Assisted Laser Desorption Ionization Mass Spectrometry for Rapid Screening of Parabens in Personal Care Products" . | RAPID COMMUNICATIONS IN MASS SPECTROMETRY 39 . 7 (2025) . |
APA | Zheng, Wenjun , Yan, Jingjing , Jin, Yingxue , Lin, Zian , Cai, Zongwei . Covalent Organic Framework Nanofilm-Assisted Laser Desorption Ionization Mass Spectrometry for Rapid Screening of Parabens in Personal Care Products . | RAPID COMMUNICATIONS IN MASS SPECTROMETRY , 2025 , 39 (7) . |
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Phenolic compounds are a kind of persistent organic pollutants (POPs), which are always a threat to human and environment due to their strong toxicity and low biodegradability. Therefore, developing a reliable method to simultaneously detect phenolic pollutants is of great importance to environmental safety and human health. Herein, we combined the advantages of metal organic frameworks (MOFs) and covalent organic frameworks (COFs) to prepare two cyclic trinuclear unit-based metal covalent organic framework (MCOFs, denoted as Cu3- TDH COF and Cu3-BDU COF) with large specific surface area, good stability and excellent laccase-like activity. Their oxidative degradation ability toward phenolic pollutants was verified, and a dual-channel nanozyme sensor array based on Cu3-TDH COF and Cu3-BDU COF was constructed for the identification of six phenolic pollutants. Notably, the sensor array can accurately distinguish between different concentrations of phenolic pollutants and different types of phenolic pollutants at the same concentration, even at levels as low as 1 mu M. Moreover, three real water samples (rainwater, tap water and wastewater) and 18 unknown samples were also distinguished and differentiated by the sensor array. This study opens up a potential avenue for the design of MCOFs-based nanozyme sensor arrays to simultaneously realize identification and detection of multiple phenolic pollutants.
Keyword :
Catalytic oxidation Catalytic oxidation Laccase-like nanozymes Laccase-like nanozymes Metal covalent organic frameworks Metal covalent organic frameworks Phenolic pollutants Phenolic pollutants Sensor array Sensor array
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GB/T 7714 | Liu, Jin , Hu, Cong , Meng, Xiaoyan et al. Metal covalent organic frameworks-based laccase-like nanozyme for oxidative degradation and identification of phenolic pollutants [J]. | JOURNAL OF HAZARDOUS MATERIALS , 2025 , 487 . |
MLA | Liu, Jin et al. "Metal covalent organic frameworks-based laccase-like nanozyme for oxidative degradation and identification of phenolic pollutants" . | JOURNAL OF HAZARDOUS MATERIALS 487 (2025) . |
APA | Liu, Jin , Hu, Cong , Meng, Xiaoyan , Sun, Ying , Zhao, Bo , Lin, Zian . Metal covalent organic frameworks-based laccase-like nanozyme for oxidative degradation and identification of phenolic pollutants . | JOURNAL OF HAZARDOUS MATERIALS , 2025 , 487 . |
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Nanozymes-based optical sensors are widely used in the field of disease diagnosis, but most of the metal-based nanomaterials with peroxidase-like would not only require the addition of unstable and slightly toxic hydrogen peroxide but also often be affected by their own oxidase-like activity leading to the problems such as poor reproducibility and environmental pollution. Moreover, single-mode biosensors are subject to signal instability, which can lead to false-positive or false-negative results. Hence, we synthesized two three-component covalent organic frameworks (COFs) with the oxidase-like and ascorbate oxidase-like activities using benzo[1,2-b:3,4b':5,6-b"]trithiophene-2,5,8-tricarboxaldehyde (BTT) and 1,3,5-tris(4-formylphenyl)benzene (TFPB) as the nodes, and 1,4-diaminobenzene (PA) and 4,4-diaminodiphenyl (BD) as the linker units. Both three-component COFs had narrow band gaps (2.16 eV and 2.27 eV), excellent electron transport properties, and high enzymelike specific activities (4.32 U mg(-1) and 1.82 U mg(-1)). Based on these, a colorimetric and ratiometric fluorescence dual-mode cascade catalytic platform was developed to detect the activity of alkaline phosphatase (ALP), a marker for diseases such as liver and bone. The constructed analytical methods had a detection limit as low as 0.10 U L-1 and were successfully used to detect ALP levels in human serum. This work also provides a new idea for developing an efficient multimodal detection and evaluation platform using nanozymes based on novel COFs.
Keyword :
Alkaline phosphatase Alkaline phosphatase Biosensor Biosensor Dual-mode detection Dual-mode detection Light-activated nanozymes Light-activated nanozymes Three-component covalent organic frameworks Three-component covalent organic frameworks
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GB/T 7714 | Hu, Cong , Li, Guorong , Xue, Yuandi et al. Light-activated bifunctional nanozymes based on three-component covalent organic frameworks for colorimetric and ratiometric fluorescence dual-mode detection of alkaline phosphatase [J]. | SENSORS AND ACTUATORS B-CHEMICAL , 2025 , 422 . |
MLA | Hu, Cong et al. "Light-activated bifunctional nanozymes based on three-component covalent organic frameworks for colorimetric and ratiometric fluorescence dual-mode detection of alkaline phosphatase" . | SENSORS AND ACTUATORS B-CHEMICAL 422 (2025) . |
APA | Hu, Cong , Li, Guorong , Xue, Yuandi , Liu, Jin , Cai, Zongwei , Lin, Zian . Light-activated bifunctional nanozymes based on three-component covalent organic frameworks for colorimetric and ratiometric fluorescence dual-mode detection of alkaline phosphatase . | SENSORS AND ACTUATORS B-CHEMICAL , 2025 , 422 . |
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RationalBenzophenone derivatives, commonly used as UV filters in personal care products (PCPs), are widely prevalent and raise concerns due to their endocrine-disrupting effects. Sensitive and efficient analytical methods are in demand for their detection. In this study, we developed a TAPB-DMTP-covalent organic framework (COF) nanofilm-assisted laser desorption ionization mass spectrometry (LDI-MS) method for the quantitative analysis of 2,4-dihydroxybenzophenone (BP-1) in PCPs.MethodsThe TAPB-DMTP-COF nanofilm was synthesized on indium tin oxide (ITO) glass and utilized as an LDI-MS substrate. The performance of TAPB-DMTP-COF nanofilm-assisted LDI-MS for analyzing small molecules (e.g., benzophenone derivatives, phthalates, amino acids, sugars, and nucleosides) was compared to conventional organic matrices (alpha-cyano-4-hydroxycinnamic acid [CHCA], 2,5-dihydroxybenzoic acid [DHB], and sinapinic acid [SA]). The reproducibility, salt resistance, sensitivity, and stability of the method were further evaluated. Finally, the technique was applied to quantify BP-1 in PCPs.ResultsThe TAPB-DMTP-COF nanofilm-assisted LDI-MS provided stronger mass spectral signals and cleaner backgrounds for small molecules compared to CHCA, DHB, and SA. The method exhibited high reproducibility (RSD = 6.10%) and stability for up to 30 days. BP-1 in PCPs was quantified with excellent linearity (1-20 mu g/mL, r = 0.9993), a low detection limit (0.3 mu g/mL), and recovery rates of 94.2%-104.4%, demonstrating the potential of TAPB-DMTP-COF nanofilm for sensitive and reliable small-molecule analysis.ConclusionTAPB-DMTP-COF nanofilm-assisted LDI-MS offered the advantages of rapid analysis, clean backgrounds, and reproducibility for detecting small molecules, including benzophenone derivatives. This method successfully quantified BP-1 in PCPs, highlighting its suitability for analyzing complex samples.
Keyword :
benzophenone derivatives benzophenone derivatives covalent organic framework nanofilm covalent organic framework nanofilm endocrine disruptors endocrine disruptors laser desorption ionization mass spectrometry laser desorption ionization mass spectrometry personal care products personal care products
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GB/T 7714 | Yan, Ling , Zheng, Wenjun , Lin, Zian . Covalent Organic Framework Nanofilm-Assisted Laser Desorption Ionization Mass Spectrometry for the Determination of Benzophenone Derivatives in Personal Care Products [J]. | RAPID COMMUNICATIONS IN MASS SPECTROMETRY , 2025 , 39 (10) . |
MLA | Yan, Ling et al. "Covalent Organic Framework Nanofilm-Assisted Laser Desorption Ionization Mass Spectrometry for the Determination of Benzophenone Derivatives in Personal Care Products" . | RAPID COMMUNICATIONS IN MASS SPECTROMETRY 39 . 10 (2025) . |
APA | Yan, Ling , Zheng, Wenjun , Lin, Zian . Covalent Organic Framework Nanofilm-Assisted Laser Desorption Ionization Mass Spectrometry for the Determination of Benzophenone Derivatives in Personal Care Products . | RAPID COMMUNICATIONS IN MASS SPECTROMETRY , 2025 , 39 (10) . |
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Membrane technology, as an efficient and eco-friendly separation means, has demonstrated substantial superiority in liquid-based separation and plays a pivotal role in environmental conservation and resource utilization. Traditional polymer-based membranes have long dominated the market for their simple preparation and low cost. But the disordered structure and irregular aperture of conventional amorphous membranes seriously hinder their performance. Recently, the emergence of covalent organic frameworks (COFs) has brought new vigor to membrane-based separation. COFs, connected by covalent bonds, have good crystallization and regular and uniform pore structure, thereby showcasing excellent stability and separation performance, becoming an ideal membrane material. In this paper, the synthesis and modification of COF-based membranes were reviewed, their inherent properties were also introduced. Besides, their applications in liquid-based separation were elaborated. Lastly, the challenges and focal points were discussed, aiming at offering inspirations for the development of COF-based membranes.
Keyword :
Covalent organic frameworks Covalent organic frameworks Membrane Membrane Separation Separation Synthesis Synthesis Water treatment Water treatment
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GB/T 7714 | Dong, Shaofeng , Xue, Yuandi , Li, Songtao et al. Recent advances in the synthesis of covalent organic framework-based membranes and their applications for liquid-based separation [J]. | TRAC-TRENDS IN ANALYTICAL CHEMISTRY , 2025 , 185 . |
MLA | Dong, Shaofeng et al. "Recent advances in the synthesis of covalent organic framework-based membranes and their applications for liquid-based separation" . | TRAC-TRENDS IN ANALYTICAL CHEMISTRY 185 (2025) . |
APA | Dong, Shaofeng , Xue, Yuandi , Li, Songtao , Zhang, Yajing , Wang, Shuyi , Lin, Zian . Recent advances in the synthesis of covalent organic framework-based membranes and their applications for liquid-based separation . | TRAC-TRENDS IN ANALYTICAL CHEMISTRY , 2025 , 185 . |
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The discharge of oily wastewater poses a serious threat to human health and the ecological environment. The development of effective oil-water separation techniques is critical to addressing this issue. Herein, a side-chain engineering strategy was proposed to construct nanoscale covalent organic frameworks (COFs) decorated stainless steel nets (SSN) with tunable wettability (SSN@COFs-C) via the introduction of three distinct lengths of alkyl chains. The nanoscale COFs particles were uniformly distributed on the SSN substrate, resulting in a hierarchical surface structure that significantly enhanced the material's hydrophobicity. Unlike conventional approaches, COFs provide a robust and tunable platform to address challenges in achieving durable superhydrophobic surfaces and overcome key development barriers such as stability and reusability. The SSN@COFs-C exhibited high hydrophobicity (water contact angle of 151.1-157.3 degrees) and self-cleaning properties. The optimal composite was capable of separating immiscible oil/water mixtures with a flux of 6079 L m-2 h-1 and exhibited an oil/water separation efficiency exceeding 99.0%. Moreover, it effectively separated surfactant-stabilized water-in-oil emulsions with a separation efficiency greater than 99% and retained their performance after multiple reused cycles. This work provides insight into the fabrication and application of nanoscale hydrophobic oil-water separation composites.
Keyword :
adjustable hydrophobicity adjustable hydrophobicity covalent organic frameworks covalent organic frameworks emulsionseparation emulsionseparation oil/waterseparation oil/waterseparation side-chain engineering side-chain engineering stainless steel net stainless steel net
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GB/T 7714 | Dong, Jinghan , Dong, Shaofeng , Ye, Zhi et al. Superhydrophobic Nanoporous Covalent Organic Frameworks Decorated on Stainless Steel Nets for Oil/Water Separation [J]. | ACS APPLIED NANO MATERIALS , 2025 , 8 (5) : 2299-2309 . |
MLA | Dong, Jinghan et al. "Superhydrophobic Nanoporous Covalent Organic Frameworks Decorated on Stainless Steel Nets for Oil/Water Separation" . | ACS APPLIED NANO MATERIALS 8 . 5 (2025) : 2299-2309 . |
APA | Dong, Jinghan , Dong, Shaofeng , Ye, Zhi , Li, Songtao , Lin, Zian . Superhydrophobic Nanoporous Covalent Organic Frameworks Decorated on Stainless Steel Nets for Oil/Water Separation . | ACS APPLIED NANO MATERIALS , 2025 , 8 (5) , 2299-2309 . |
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