Isomerization　of　alkane　is　one　of　the　most　important　catalytic　processes　for　producing　environmentally　friendly　gasoline　fraction　with　high　octane　number.　However,　the　development　of　non-noble　metal　based　catalysts　with　high　conversion　and　selectivity　towards　multi-branched　isomerized　products　is　still　challenging.　Herein,　we　report　that　a　NiP-H　beta/modified　Kaolin　catalyst　was　successfully　prepared　by　ball-milling　of　amorphous　NiP　nanoparticles　with　H　beta/modified　Kaolin　composites　and　applied　for　n-hexane　isomerization.　The　introduction　of　chemically　modified　Kaolin　with　abundant　weak-medium　acid　sites　and　mesopores　not　only　alleviates　the　cracking　of　isomerized　products　on　the　strong　acid　sites　on　H　beta,　but　also　provides　more　active　sites　for　the　formation　of　di-branched　isomerized　products　with　high　octane　number.　As　a　result,　the　NiP-H　beta/modified　Kaolin　catalyst　shows　an　excellent　catalytic　performance　for　n-hexane　isomerization　in　terms　of　good　conversion　(78.1%),　high　selectivity　towards　mono-branched　(75.4%)　and　di-branched　(21.4%)　i-C-6　products,　and　high　liquid　yield　(99.9%).　This　work　paves　the　way　to　the　development　of　high　performance　non-noble　metal　based　catalysts　for　large　scale　production　of　clean　gasoline.