We　report　a　facile　yet　effective　strategy　to　prepare　hierarchical　Beta　zeolite　with　high　molecular　transport　effectivity　in　catalysis.　Alkaline　etching　involves　preferential　desilication　from　Beta　framework　and　collapse　of　microporosity.　The　preferential　desilication　from　outer　rim　of　Beta　stacking　faults　enlarged　intercrystallite　mesopores,　while　the　collapse　of　microporosity　created　cylindroid-like　intracrystalline　mesopore.　Part　of　Altet　with　lower　stability　was　removed　during　alkaline　etching,　leading　to　a　decrease　in　acid　sites　density.　Alkaline　etching　of　Beta　zeolite　with　0.2　mol/L　NaOH　solution　greatly　improved　n-hexane　isomerization　activity　over　Pt-based　catalysts.　The　maximum　yield　of　isohexane　and　dibranched　isomers　increased　by　6.2　%　and　38.6　%,　respectively.　The　enlargement　of　intercrystallite　mesopores　and　the　generation　of　intracrystalline　mesopores　of　Beta　zeolite　lowered　apparent　activation　energy　of　reaction.　The　apparent　diffusivities　measurements　further　revealed　that　Pt/Beta-0.2　M　showed　much　lower　transport　limitation　than　Pt/Beta-parent.　Our　findings　provide　a　promising　catalyst　for　industrial　alkane　isomerization.　©　2024　Elsevier　Ltd