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author:

Huang, Da (Huang, Da.) [1] (Scholars:黄达) | Du, Jiahao (Du, Jiahao.) [2] | Luo, Fang (Luo, Fang.) [3] (Scholars:罗芳) | He, Gang (He, Gang.) [4] | Zou, Minglang (Zou, Minglang.) [5] | Wang, Yongming (Wang, Yongming.) [6] | Lin, Zhenyu (Lin, Zhenyu.) [7] (Scholars:林振宇) | Wu, Decheng (Wu, Decheng.) [8] | Weng, Zuquan (Weng, Zuquan.) [9] (Scholars:翁祖铨)

Indexed by:

EI Scopus SCIE

Abstract:

Hydrogel dressings capable of infection monitoring and precise treatment administration show promise for advanced wound care. Existing methods involve embedd ingorganic dyes or flexible electronics into preformed hydrogels, which raise safety issues and adaptability challenges. In this study, an injectable hydrogel based smart wound dressing is developed by integrating food-derived anthocyanidin as a visual pH probe for infection monitoring and poly(L-lactic acid) microcapsules as ultrasound-responsive delivery systems for antibiotics into a poly(ethylene glycol) hydrogel. This straightforwardly prepared hydrogel dressing maintains its favorable properties for wound repair, including porous morphology and excellent biocompatibility. In vitro experiments demonstrated that the hydrogel enabled visual assessment of pH within the range of 5 similar to 9.Meanwhile, the release of antibiotics could be triggered and controlled by ultrasound. In vivo evaluations using infected wounds and diabetic wounds revealed that the wound dressing effectively detected wound infection by monitoring pH levels and achieved antibacterial effects through ultrasound-triggered drug release. This led to significantly enhanced wound healing, as validated by histological analysis and the measurement of inflammatory cytokine levels. This injectable hydrogel-based smart wound dressing holds great potential for use in clinical settings to inform timely and precise clinical intervention and in community to improve wound care management. The study presents an injectable hydrogel dressing with flexibility to fit irregularly shaped wounds and excellent biocompatibility for visual monitoring of infection and on-demand treatment. It utilizes food-derived anthocyanidin as a pH probe and poly(L-lactic acid) microcapsules for ultrasound-responsive drug delivery. In diabetic wounds, the dressing detects infections through pH monitoring and enhances healing via ultrasound-triggered drug release.image

Keyword:

chronic wounds hydrogels on-demand treatment pH detection ultrasound responsive wound monitoring

Community:

  • [ 1 ] [Huang, Da]Fuzhou Univ, Coll Biol Sci & Engn, Fuzhou 350108, Fujian, Peoples R China
  • [ 2 ] [Du, Jiahao]Fuzhou Univ, Coll Biol Sci & Engn, Fuzhou 350108, Fujian, Peoples R China
  • [ 3 ] [Luo, Fang]Fuzhou Univ, Coll Biol Sci & Engn, Fuzhou 350108, Fujian, Peoples R China
  • [ 4 ] [Zou, Minglang]Fuzhou Univ, Coll Biol Sci & Engn, Fuzhou 350108, Fujian, Peoples R China
  • [ 5 ] [Wang, Yongming]Fuzhou Univ, Coll Biol Sci & Engn, Fuzhou 350108, Fujian, Peoples R China
  • [ 6 ] [Weng, Zuquan]Fuzhou Univ, Coll Biol Sci & Engn, Fuzhou 350108, Fujian, Peoples R China
  • [ 7 ] [Huang, Da]Fuzhou Univ, Coll Chem, Fujian Prov Key Lab Anal & Detect Food Safety, Minist Educ,Key Lab Analyt Sci Food Safety & Biol, Fuzhou 350108, Fujian, Peoples R China
  • [ 8 ] [Luo, Fang]Fuzhou Univ, Coll Chem, Fujian Prov Key Lab Anal & Detect Food Safety, Minist Educ,Key Lab Analyt Sci Food Safety & Biol, Fuzhou 350108, Fujian, Peoples R China
  • [ 9 ] [Lin, Zhenyu]Fuzhou Univ, Coll Chem, Fujian Prov Key Lab Anal & Detect Food Safety, Minist Educ,Key Lab Analyt Sci Food Safety & Biol, Fuzhou 350108, Fujian, Peoples R China
  • [ 10 ] [He, Gang]Southern Univ Sci & Technol, Dept Biomed Engn, Shenzhen 518055, Peoples R China
  • [ 11 ] [Wu, Decheng]Southern Univ Sci & Technol, Dept Biomed Engn, Shenzhen 518055, Peoples R China
  • [ 12 ] [Weng, Zuquan]Fujian Med Univ, Dept Plast Surg, Affiliated Hosp 1, Fuzhou 350005, Fujian, Peoples R China

Reprint 's Address:

  • 林振宇 翁祖铨

    [Weng, Zuquan]Fuzhou Univ, Coll Biol Sci & Engn, Fuzhou 350108, Fujian, Peoples R China;;[Lin, Zhenyu]Fuzhou Univ, Coll Chem, Fujian Prov Key Lab Anal & Detect Food Safety, Minist Educ,Key Lab Analyt Sci Food Safety & Biol, Fuzhou 350108, Fujian, Peoples R China;;[Wu, Decheng]Southern Univ Sci & Technol, Dept Biomed Engn, Shenzhen 518055, Peoples R China;;[Weng, Zuquan]Fujian Med Univ, Dept Plast Surg, Affiliated Hosp 1, Fuzhou 350005, Fujian, Peoples R China

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Source :

ADVANCED HEALTHCARE MATERIALS

ISSN: 2192-2640

Year: 2024

Issue: 9

Volume: 13

1 0 . 0 0 0

JCR@2023

Cited Count:

WoS CC Cited Count: 5

SCOPUS Cited Count: 6

ESI Highly Cited Papers on the List: 0 Unfold All

WanFang Cited Count:

Chinese Cited Count:

30 Days PV: 2

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