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[期刊论文]

Chitosan nonwoven fabric composited calcium alginate and adenosine diphosphate as a hemostatic bandage for acute bleeding wounds

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author:

Yang, Jianmin (Yang, Jianmin.) [1] (Scholars:杨建民) | Cai, Fengying (Cai, Fengying.) [2] | Lv, Yicheng (Lv, Yicheng.) [3] | Unfold

Indexed by:

EI Scopus SCIE

Abstract:

Acute bleeding following accidental injury is a leading cause of mortality. However, conventional hemostatic bandages impede wound healing by inducing excessive blood loss, dehydration, and adherence to granulation tissue. Strategies such as incorporating active hemostatic agents and implementing chemical modifications can augment the properties of these bandages. Nevertheless, the presence of remote thrombosis and initiators may pose risks to human health. Here, a hemostatic bandage was developed by physically combined chitosan nonwoven fabric, calcium alginate sponge, and adenosine diphosphate. The presented hemostatic bandage not only exhibits active and passive mechanisms for promoting clotting but also demonstrates excellent mechanical properties, breathability, ease of removal without causing damage to the wound bed or surrounding tissues, as well as maintaining an optimal moist environment conducive to wound healing. In vitro evaluation results indicated that the hemostatic bandage possesses favorable cytocompatibility with low levels of hemolysis. Furthermore, it effectively aggregates various blood cells while activating platelets synergistically to promote both extrinsic and intrinsic coagulation pathways. In an in vivo rat model study involving liver laceration and femoral artery injury scenarios, our developed hemostatic bandage demonstrated rapid clot formation capabilities along with reduced blood loss compared to commercially available fabrics.

Keyword:

Acute bleeding wound Chitosan nonwoven fabric Hemostatic bandage Hemostatic mechanisms Synergistic hemostatic

Community:

  • [ 1 ] [Yang, Jianmin]Fuzhou Univ, Coll Biol Sci & Engn, 2 Xueyuan Rd, Fuzhou 350108, Peoples R China
  • [ 2 ] [Cai, Fengying]Fuzhou Univ, Coll Biol Sci & Engn, 2 Xueyuan Rd, Fuzhou 350108, Peoples R China
  • [ 3 ] [Lv, Yicheng]Fuzhou Univ, Coll Biol Sci & Engn, 2 Xueyuan Rd, Fuzhou 350108, Peoples R China
  • [ 4 ] [Jiang, Ting]Fuzhou Univ, Coll Biol Sci & Engn, 2 Xueyuan Rd, Fuzhou 350108, Peoples R China
  • [ 5 ] [Zhao, Xingkai]Fuzhou Univ, Coll Biol Sci & Engn, 2 Xueyuan Rd, Fuzhou 350108, Peoples R China
  • [ 6 ] [Hu, Xueli]Fuzhou Univ, Coll Biol Sci & Engn, 2 Xueyuan Rd, Fuzhou 350108, Peoples R China
  • [ 7 ] [Shi, Xianai]Fuzhou Univ, Coll Biol Sci & Engn, 2 Xueyuan Rd, Fuzhou 350108, Peoples R China
  • [ 8 ] [Yang, Jianmin]Fuzhou Univ, Fujian Key Lab Med Instrument & Pharmaceut Technol, 2 Xueyuan Rd, Fuzhou 350108, Peoples R China
  • [ 9 ] [Zheng, Yunquan]Fuzhou Univ, Fujian Key Lab Med Instrument & Pharmaceut Technol, 2 Xueyuan Rd, Fuzhou 350108, Peoples R China
  • [ 10 ] [Shi, Xianai]Fuzhou Univ, Fujian Key Lab Med Instrument & Pharmaceut Technol, 2 Xueyuan Rd, Fuzhou 350108, Peoples R China

Reprint 's Address:

  • [Yang, Jianmin]Fuzhou Univ, Coll Biol Sci & Engn, 2 Xueyuan Rd, Fuzhou 350108, Peoples R China;;[Shi, Xianai]Fuzhou Univ, Coll Biol Sci & Engn, 2 Xueyuan Rd, Fuzhou 350108, Peoples R China;;

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Source :

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

ISSN: 0141-8130

Year: 2023

Volume: 257

7 . 7

JCR@2023

7 . 7 0 0

JCR@2023

JCR Journal Grade:1

CAS Journal Grade:1

Cited Count:

WoS CC Cited Count: 6

SCOPUS Cited Count: 4

30 Days PV: 0

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