Acute　bleeding　following　accidental　injury　is　a　leading　cause　of　mortality.　However,　conventional　hemostatic　bandages　impede　wound　healing　by　inducing　excessive　blood　loss,　dehydration,　and　adherence　to　granulation　tissue.　Strategies　such　as　incorporating　active　hemostatic　agents　and　implementing　chemical　modifications　can　augment　the　properties　of　these　bandages.　Nevertheless,　the　presence　of　remote　thrombosis　and　initiators　may　pose　risks　to　human　health.　Here,　a　hemostatic　bandage　was　developed　by　physically　combined　chitosan　nonwoven　fabric,　calcium　alginate　sponge,　and　adenosine　diphosphate.　The　presented　hemostatic　bandage　not　only　exhibits　active　and　passive　mechanisms　for　promoting　clotting　but　also　demonstrates　excellent　mechanical　properties,　breathability,　ease　of　removal　without　causing　damage　to　the　wound　bed　or　surrounding　tissues,　as　well　as　maintaining　an　optimal　moist　environment　conducive　to　wound　healing.　In　vitro　evaluation　results　indicated　that　the　hemostatic　bandage　possesses　favorable　cytocompatibility　with　low　levels　of　hemolysis.　Furthermore,　it　effectively　aggregates　various　blood　cells　while　activating　platelets　synergistically　to　promote　both　extrinsic　and　intrinsic　coagulation　pathways.　In　an　in　vivo　rat　model　study　involving　liver　laceration　and　femoral　artery　injury　scenarios,　our　developed　hemostatic　bandage　demonstrated　rapid　clot　formation　capabilities　along　with　reduced　blood　loss　compared　to　commercially　available　fabrics.　©　2023　Elsevier　B.V.