Aerobic　oxidation　of　5-hydroxymethylfurfural　(HMF)　to　2,5-furandicarboxylic　acid　(FDCA)　offers　an　appealing　way　to　transform　the　biomass　feedstock　into　chemical　commodities　but　suffers　from　low　efficiency　and　selectivity　due　to　the　formation　of　5-formyl-2-furancarboxylic　acid　(FFCA)　byproduct.　Herein,　we　demonstrated　that　an　amorphous　MnO2　(amor-MnO2)　nanostructure　having　a　disordered　lattice　structure　can　carry　O-L　of　high　reactivity　for　catalyzing　the　aerobic　oxidation　of　HMF　to　prepare　FDCA　efficiently　and　selectively.　The　FDCA　formation　rate　of　amor-MnO2　reaches　up　to　1307　mu　mol(FDCA)　g(cat)(-1)　h(-1),　about　8.2　times　that　of　crystalline　MnO2　(cry-MnO2)　(160　mu　mol(FDCA)　g(cat)(-1)　h(-1))　and　surpassing　many　other　state-of-the-art　Mn-based　catalysts.　Kinetic　studies　reveal　that　the　amor-MnO2　nanostructure　can　efficiently　convert　the　low-concentration　FFCA　intermediate　into　FDCA,　which　helps　tackle　the　rate-determining　step　in　the　HMF　-＞　FFCA　-＞　FDCA　oxidation　process.　Density　functional　theory　calculations　and　experimental　measurements　demonstrate　that　amor-MnO2　delivers　superior　lattice　oxygen　(O-L)　activity　and　stronger　O-2　adsorption　capability　when　compared　with　the　crystalline　counterpart.　The　findings　showcase　the　use　of　amorphous　materials　as　advanced　catalysts　for　achieving　sustainable　chemistry　industry.