In　this　work,　acidic　ionic　liquid　(AIL)　was　grafted　into　NH2-UiO-66　through　acid-base　interaction.　And　the　novel　heterogeneous　catalyst　xAIL@NH2-UiO-66　(x　means　the　mass　ratio　of　AIL　to　NH2-UiO-66)　was　first　applied　in　the　field　of　biodiesel　production.　The　optimal　catalyst　3AIL@NH2-UiO-66　with　good　wettability　(with　reactants)　and　high　acidity　was　prepared　successfully.　Accordingly,　the　3AIL@NH2-UiO-66　can　be　widely　applied　in　biodiesel　production　from　different　raw　materials.　The　conversion　of　free　fatty　acids　(FFAs)　in　esterification　was　above　90%,　as　well　as　the　biodiesel　yield　in　transesterification　was　above　80%,　showing　excellent　catalytic　activities　of　3AIL@NH2-UiO-66.　And　the　3AIL@NH2-UiO-66　also　revealed　excellent　reusability,　with　the　conversion　of　oleic　acid　decreases　from　96.86%　to　90.42%　after　6　runs.　In　addition,　the　interaction　between　any　two　of　the　three　factors　(catalyst　dosage,　reaction　time　and　molar　ratio)　on　the　oleic　acid　conversion　was　revealed　with　3D　response　surface　technology.　By　the　mechanism　investigation,　the　good　wettability　with　reactants　and　high　acidity　of　the　catalysts　are　identified　as　key　factors　for　biodiesel　production.　The　method　of　anchoring　ionic　liquids　with　organic　linkers　for　the　application　of　MOFs　in　biodiesel　production　offers　abundant　possibilities.