Breccia-hosted　Sr-(Pb-Zn)　mineralization　from　the　Shizilishan　deposit　(Edong　district,　eastern　China)　is　located　at　the　contact　between　a　Lower　Cretaceous　(∼139　Ma)　quartz　diorite　porphyry　stock　and　Triassic　evaporite-bearing　limestone/dolomite　sequences.　Backscatter　electron　imaging,　electron　probe　microanalysis,　and　laser　ablation　(multicollector-)　inductively　coupled-plasma　mass　spectrometry　constrain　ore　genesis　based　on　the　textural　evolution　and　trace　element　and　isotope　geochemistry　in　multiple　stages　of　celestine　and　sulfides　(pyrite　and　marcasite).　Complex　growth　and/or　dissolution　and/or　recrystallization　textures　of　celestine　and　superposition　of　pyrite　and　marcasite　are　suggestive　of　evolving　fluid　compositions　and　physicochemical　conditions　during　which　pH　first　decreased　(favorable　for　marcasite　precipitation)　and　then　increased,　facilitating　precipitation　of　Ba-rich　celestine　and　As-rich　pyrite.　Sphalerite　is　characterized　by　enrichment　in　structurally-bound　Sb,　Cu,　Ag,　As,　and　Tl.　Celestine　displays　Sr　and　S　isotope　signatures　comparable　to　Middle　Triassic　seawater,　indicating　derivation　of　both　elements　from　evaporite　sequences.　Decreasing　δ34S　in　sulfides　through　the　paragenetic　sequence　may　reflect　multiple　sulfur　sources　produced　by　thermochemical　reduction　of　sulfate　and/or　bacterial　sulfate　reduction　processes.　This　research　highlights　that　low　to　moderate　salinity　fluids,　expected　to　carry　significant　concentrations　of　Sr,　are　able　to　form　large　celestine　deposits　through　extensive　water–rock　interaction　when　fluid　flow　is　either　protracted,　or　there　are　superimposed　episodes　of　fluid　introduction　with　high　Sr/Ba　ratios　and　moderate　dissolved　sulfate.　The　Shizilishan　deposit　shares　some　alteration　features　and　geochemical　signatures　with　low-temperature　Carlin-type　Au　deposits　(e.g.,　relative　enrichment　in　As　and　Tl　in　ore-stage　pyrite)　and　Fe-poor　MVT-type　Pb-Zn　ores　(e.g.,　high　content　of　Ga　and　Ge　but　low　Fe,　Mn,　and　In　in　sphalerite).　©　2022　The　Authors